PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35489292-0	2022	Ameliorative effect of betulinic acid against zearalenone exposure triggers testicular dysfunction and oxidative stress in mice via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation.	betulinic acid	23-37	mitogen-activated protein kinase 14	Mus musculus	132-135	
35489292-7	2022	Furthermore, BA moderated ZEA-evoked testicular inflammation by inhibiting p38/ERK MAPK pathway.	betulinic acid	13-15	mitogen-activated protein kinase 14	Mus musculus	75-78	
35489292-8	2022	Overall, our results revealed that BA has a therapeutic protective effect on ZEA-induced testicular injury and oxidative stress via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation, which provides a viable alternative to alleviate ZEA-induced male reproductive toxicology.	betulinic acid	35-37	mitogen-activated protein kinase 14	Mus musculus	132-135	
33499152-7	2021	Furthermore, administration of BA alleviated the protein phosphorylation of p38, c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinases (ERK); decreased the protein expression of kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein1 (Keap1); and increased the protein expression of nuclear factor erythroid 2 [NF-E2]-related factor (Nrf2) and heme oxygenase-1 (HO-1) in the spleen.	betulinic acid	31-33	mitogen-activated protein kinase 14	Mus musculus	76-79	
31545273-7	2019	Besides, BA reduced neutrophil infiltration in the basal and subcutaneous layers of the paw of Carr-treated mice, decreased the expression of COX-2 protein, and reduced the phosphorylation of JNK, p38 and ERK1/2.	betulinic acid	9-11	mitogen-activated protein kinase 14	Mus musculus	197-200	
32733253-7	2020	Western blot analysis revealed that BA significantly interrupted ERK, JNK and p38 MAPK activation as well as intracellular reactive oxygen species (ROS) production, thus altering c-Fos and NFATc1 activation.	betulinic acid	36-38	mitogen-activated protein kinase 14	Mus musculus	78-86	
29677535-0	2018	Betulinic acid attenuates dexamethasone-induced oxidative damage through the JNK-P38 MAPK signaling pathway in mice.	betulinic acid	0-14	mitogen-activated protein kinase 14	Mus musculus	81-89	
29677535-7	2018	Concomitant with these biochemical parameters, BA pretreatment significantly reduced gene and protein expressions of apoptosis signal-regulating kinase 1 (ASK1), c-Jun N-terminal kinase (JNK) and P38 mitogen-activated protein kinase (P38 MAPK) in the lymphatic organs of Dex-treated mice.	betulinic acid	47-49	mitogen-activated protein kinase 14	Mus musculus	196-232	
29677535-7	2018	Concomitant with these biochemical parameters, BA pretreatment significantly reduced gene and protein expressions of apoptosis signal-regulating kinase 1 (ASK1), c-Jun N-terminal kinase (JNK) and P38 mitogen-activated protein kinase (P38 MAPK) in the lymphatic organs of Dex-treated mice.	betulinic acid	47-49	mitogen-activated protein kinase 14	Mus musculus	234-242	
27188281-0	2016	Betulinic acid synergically enhances BMP2-induced bone formation via stimulating Smad 1/5/8 and p38 pathways.	betulinic acid	0-14	mitogen-activated protein kinase 14	Mus musculus	96-99