PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31814899-0	2019	Betulinic acid induces autophagy-mediated apoptosis through suppression of the PI3K/AKT/mTOR signaling pathway and inhibits hepatocellular carcinoma.	betulinic acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	84-87	
33251156-8	2020	Bioinformatics analysis indicated Akt pathway activation by BA treatment.	betulinic acid	60-62	AKT serine/threonine kinase 1	Homo sapiens	34-37	
33251156-9	2020	This was confirmed by phosphorylated Akt analysis, both in BA-treated NPCs and brain organoids, as shown by immunoblotting and immunofluorescence analyses, respectively.	betulinic acid	59-61	AKT serine/threonine kinase 1	Homo sapiens	37-40	
31814899-11	2019	Additionally, apoptosis and autophagy were induced by BA through suppression of the PI3K/AKT/mTOR signaling pathway.	betulinic acid	54-56	AKT serine/threonine kinase 1	Homo sapiens	89-92	
31814899-12	2019	Collectively, our study provides experimental evidence that BA inhibits cell proliferation and induces cell apoptosis and autophagy via suppressing the PI3K/AKT/mTOR pathway.	betulinic acid	60-62	AKT serine/threonine kinase 1	Homo sapiens	157-160	
21077850-7	2011	KEY RESULTS: BA inhibited LPS-induced COX-2 protein expression and prostaglandin E(2) production and also attenuated LPS-induced ERK and Akt phosphorylation, but not p38 in hPBMCs.	betulinic acid	13-15	AKT serine/threonine kinase 1	Homo sapiens	137-140	
29039440-0	2017	Betulinic acid induces apoptosis by regulating PI3K/Akt signaling and mitochondrial pathways in human cervical cancer cells.	betulinic acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	52-55	
29039440-3	2017	In the present study, results indicated that BA was highly effective against HeLa cells via induction of time-dependent apoptosis, and the authors demonstrated that the BA treatment acted through downregulating a phosphatidylinositol 3-kinase (PI3K) subunit and suppressing the Akt phosphorylation at Thr308 and Ser473 after increasing the generation of intracellular reactive oxygen species.	betulinic acid	169-171	AKT serine/threonine kinase 1	Homo sapiens	278-281	
29039440-8	2017	Therefore, these findings demonstrated that BA induced apoptosis in HeLa cells by downregulating the expression of PI3K/Akt signaling molecules via ROS, and triggering a mitochondrial pathway.	betulinic acid	44-46	AKT serine/threonine kinase 1	Homo sapiens	120-123	
27463705-0	2016	Estrogen Receptor Signaling and the PI3K/Akt Pathway Are Involved in Betulinic Acid-Induced eNOS Activation.	betulinic acid	69-83	AKT serine/threonine kinase 1	Homo sapiens	41-44	
27463705-9	2016	These results indicate that fast non-genomic effects of ER with downstream signaling through the PI3K/Akt pathway and consecutive eNOS phosphorylation at serine 1177 are involved in BA-induced eNOS activation.	betulinic acid	182-184	AKT serine/threonine kinase 1	Homo sapiens	102-105	
26013878-9	2016	Thus, our results elucidated that CBA or other BA based small molecules inhibit PI3K/AKT pathway with induction of subsequent cancer cell death which may be useful therapeutic strategy against leukemias and possibly other cancers.	betulinic acid	35-37	AKT serine/threonine kinase 1	Homo sapiens	85-88	
31344390-13	2019	The BA analogues H3, H5 and H7 are protective against glutamate-induced oxidative stress in human Muller cells, and elicit their actions by modulation of the Erk, Akt and JNK signaling pathways.	betulinic acid	4-6	AKT serine/threonine kinase 1	Homo sapiens	163-166	
34645271-5	2021	Furthermore, betulinic acid downregulated the post-translational modification of the canonical IRS1/PI3K/AKT-pT308 and IGF1/mTORC2/AKT-pS473 pathways, thereby reducing the activity of the mTOR/S6K/S6 pathway.	betulinic acid	13-27	AKT serine/threonine kinase 1	Homo sapiens	131-134	
16077934-0	2005	Transient activation of EGFR/AKT cell survival pathway and expression of survivin contribute to reduced sensitivity of human melanoma cells to betulinic acid.	betulinic acid	143-157	AKT serine/threonine kinase 1	Homo sapiens	29-32	
16077934-8	2005	Further, BA strongly induced AKT phosphorylation in a similar pattern.	betulinic acid	9-11	AKT serine/threonine kinase 1	Homo sapiens	29-32	
16077934-9	2005	AKT activation started 15 min post-treatment, peaked at approximately 1 h, remained elevated for 4 h and returned to basal level within 8 h. BA also induced ERK activation and, in contrast, weakly induced JNK and p38 activation.	betulinic acid	141-143	AKT serine/threonine kinase 1	Homo sapiens	0-3	
16077934-10	2005	Pretreatment of EGFR inhibitor PD153035 blocked BA-induced EGFR phosphorylation, ERK and AKT activation, and survivin expression.	betulinic acid	48-50	AKT serine/threonine kinase 1	Homo sapiens	89-92	
16077934-12	2005	Collectively, we conclude that betulinic acid transiently activated the EGFR/AKT cell survival pathway and induced survivin expression, contributing to less sensitivity in human melanoma cells.	betulinic acid	31-45	AKT serine/threonine kinase 1	Homo sapiens	77-80	
12606824-8	2002	Betulinic acid-induced phosphorylation and activation of the Akt protein kinase was inhibited by LY294002.	betulinic acid	0-14	AKT serine/threonine kinase 1	Homo sapiens	61-64	
34645271-5	2021	Furthermore, betulinic acid downregulated the post-translational modification of the canonical IRS1/PI3K/AKT-pT308 and IGF1/mTORC2/AKT-pS473 pathways, thereby reducing the activity of the mTOR/S6K/S6 pathway.	betulinic acid	13-27	AKT serine/threonine kinase 1	Homo sapiens	105-108	
34267658-6	2021	However, the dual treatment of BA and ERKi results in increased protective autophagy and AKT phosphorylation.	betulinic acid	31-33	AKT serine/threonine kinase 1	Homo sapiens	89-92	
34267658-7	2021	Accordingly, inhibition of AKT has a highly synergistic anticancer effect with co-treatment of BA and ERKi.	betulinic acid	95-97	AKT serine/threonine kinase 1	Homo sapiens	27-30	
35118990-0	2022	Effects of betulinic acid on AKT/mTOR pathway in renal cell carcinoma.	betulinic acid	11-25	AKT serine/threonine kinase 1	Homo sapiens	29-32	
35118990-3	2022	We aimed to determine the apoptotic effect of betulinic acid and its effects on expressions of apoptosisassociated genes AKT-1 and mTOR in RCC cells.	betulinic acid	46-60	AKT serine/threonine kinase 1	Homo sapiens	121-126	
35118990-4	2022	MATERIAL AND METHODS: In this study, we investigated the apoptotic activity of betulinic acid in CAKI-2 cell line and its effect on AKT-1 and mTOR gene expression levels.	betulinic acid	79-93	AKT serine/threonine kinase 1	Homo sapiens	132-137	
35118990-8	2022	CONCLUSION: We suggested that betulinic acid with its apoptotic effect on RCC line and nontoxic effect on healthy cell line and the effects on AKT/mTOR pathway may be a potential anticancer drug promising for future studies.	betulinic acid	30-44	AKT serine/threonine kinase 1	Homo sapiens	143-146