PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34482064-0	2021	Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-kappaB/MAPK signalling pathways and activating the Nrf2 signalling pathway.	betulinic acid	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-103	
34482064-6	2021	In addition, BA inhibited CYP-triggered intestinal inflammation through down-regulating the nuclear transcription factor kappa B (NF-kappaB)/mitogen-activating protein kinase (MAPK) pathways.	betulinic acid	13-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	92-128	
34482064-6	2021	In addition, BA inhibited CYP-triggered intestinal inflammation through down-regulating the nuclear transcription factor kappa B (NF-kappaB)/mitogen-activating protein kinase (MAPK) pathways.	betulinic acid	13-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	130-139	
34482064-8	2021	Overall, the current study demonstrated the protective effect of BA against CYP-caused intestinal mucosal damage by regulating the Nrf2 and NF-kappaB/MAPK signalling pathways, which may provide new therapeutic targets to attenuate intestinal impairment and maintain intestinal health.	betulinic acid	65-67	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	140-149	
34206763-0	2021	Betulinic Acid Ameliorates the Severity of Acute Pancreatitis via Inhibition of the NF-kappaB Signaling Pathway in Mice.	betulinic acid	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	84-93	
34206763-10	2021	Moreover, BA reduced the production of proinflammatory cytokines and NF-kappaB activation in pancreatic acinar cells (PACs).	betulinic acid	10-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-78	
34206763-11	2021	These findings suggest that BA may have prophylactic and therapeutic effects on AP via inhibition of the NF-kappaB signaling pathway.	betulinic acid	28-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-114	
34206763-9	2021	In addition, mice that were pretreated with BA showed a reduction in Ikappa-Balpha degradation and nuclear factor-kappa B (NF-kappaB) binding activity in the pancreas.	betulinic acid	44-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-121	
34206763-9	2021	In addition, mice that were pretreated with BA showed a reduction in Ikappa-Balpha degradation and nuclear factor-kappa B (NF-kappaB) binding activity in the pancreas.	betulinic acid	44-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-132	
35120573-6	2022	TLR9 inhibition also alleviated inflammation and apoptosis, which was reversed by the addition of the NF-kappaB activator, betulinic acid.	betulinic acid	123-137	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-111	
33322178-0	2020	Betulinic Acid Ameliorates the T-2 Toxin-Triggered Intestinal Impairment in Mice by Inhibiting Inflammation and Mucosal Barrier Dysfunction through the NF-kappaB Signaling Pathway.	betulinic acid	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	152-161	
33322178-9	2020	Furthermore, treatment with 1 mg/kg BA downregulated the expression of p-NF-kappaB and p-IkappaB-alpha proteins in the intestine, while all doses of BA suppressed the pro-inflammatory cytokines expression of IL-1beta, IL-6 and TNF-alpha mRNAs and increased the anti-inflammatory cytokine expression of IL-10 mRNA in the intestine of T-2 toxin-exposed mice.	betulinic acid	36-38	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	73-82	
33322178-10	2020	BA was proposed to exert a protective effect on intestinal mucosal disruption in T-2 toxin-stimulated mice by enhancing the intestinal antioxidant capacity, inhibiting the secretion of inflammatory cytokines and repairing intestinal mucosal barrier functions, which may be associated with BA-mediated inhibition of the NF-kappaB signaling pathway activation.	betulinic acid	0-2	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	319-328	
32237724-0	2020	Betulinic Acid Inhibits RANKL-Induced Osteoclastogenesis via Attenuating Akt, NF-kappaB, and PLCgamma2-Ca2+ Signaling and Prevents Inflammatory Bone Loss.	betulinic acid	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	78-87