PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27578964-0	2016	Development of betulinic acid as an agonist of TGR5 receptor using a new in vitro assay.	betulinic acid	15-29	G protein-coupled bile acid receptor 1	Homo sapiens	47-51	
34406006-2	2021	Herein, we identified a new series of betulinic acid derivatives as potent TGR5 agonists, which show remarkable activity on human (h) and canine (c) TGR5 but exhibit unpromising activity on murine (m) TGR5.	betulinic acid	38-52	G protein-coupled bile acid receptor 1	Homo sapiens	75-79	
27578964-3	2016	Betulinic acid, a triterpenoid present in the leaves of white birch, has been introduced as a selective TGR5 agonist.	betulinic acid	0-14	G protein-coupled bile acid receptor 1	Homo sapiens	104-108	
27578964-4	2016	However, direct activation of TGR5 by betulinic acid has not yet been reported.	betulinic acid	38-52	G protein-coupled bile acid receptor 1	Homo sapiens	30-34	
27578964-9	2016	RESULTS: Betulinic acid dose-dependently increases glucose uptake by CHO-K1 cells transfected with TGR5 only, which can be considered an alternative method instead of radioligand binding assay.	betulinic acid	9-23	G protein-coupled bile acid receptor 1	Homo sapiens	99-103	
27578964-11	2016	In NCI-H716 cells, which endogenously express TGR5, betulinic acid induces glucagon-like peptide secretion via increasing calcium levels.	betulinic acid	52-66	G protein-coupled bile acid receptor 1	Homo sapiens	46-50	
27578964-12	2016	However, the actions of betulinic acid were markedly reduced in NCI-H716 cells that received TGR5-silencing treatment.	betulinic acid	24-38	G protein-coupled bile acid receptor 1	Homo sapiens	93-97	
27578964-13	2016	Therefore, the present study demonstrates the activation of TGR5 by betulinic acid for the first time.	betulinic acid	68-82	G protein-coupled bile acid receptor 1	Homo sapiens	60-64	
27578964-14	2016	CONCLUSION: Similar to the positive control lithocholic acid, which is the established agonist of TGR5, betulinic acid has been characterized as a useful agonist of TGR5 and can be used to activate TGR5 in the future.	betulinic acid	104-118	G protein-coupled bile acid receptor 1	Homo sapiens	98-102	
27578964-14	2016	CONCLUSION: Similar to the positive control lithocholic acid, which is the established agonist of TGR5, betulinic acid has been characterized as a useful agonist of TGR5 and can be used to activate TGR5 in the future.	betulinic acid	104-118	G protein-coupled bile acid receptor 1	Homo sapiens	165-169	
27578964-14	2016	CONCLUSION: Similar to the positive control lithocholic acid, which is the established agonist of TGR5, betulinic acid has been characterized as a useful agonist of TGR5 and can be used to activate TGR5 in the future.	betulinic acid	104-118	G protein-coupled bile acid receptor 1	Homo sapiens	165-169	
25418122-8	2015	RESULTS: In this study, results show that triggering TGR5 with the specific agonist betulinic acid (BA), and the bile acids CDCA or DCA, activated both the main MAP kinases ERK1/2, p38 and JNK, and the NF-kappaB signaling pathway.	betulinic acid	84-98	G protein-coupled bile acid receptor 1	Homo sapiens	53-57	
25418122-8	2015	RESULTS: In this study, results show that triggering TGR5 with the specific agonist betulinic acid (BA), and the bile acids CDCA or DCA, activated both the main MAP kinases ERK1/2, p38 and JNK, and the NF-kappaB signaling pathway.	betulinic acid	100-102	G protein-coupled bile acid receptor 1	Homo sapiens	53-57	
25283506-0	2014	Highly lipophilic 3-epi-betulinic acid derivatives as potent and selective TGR5 agonists with improved cellular efficacy.	betulinic acid	18-38	G protein-coupled bile acid receptor 1	Homo sapiens	75-79	
25283506-3	2014	Here, we sought to design and synthesize a series of TGR5 agonists derived from the natural product betulinic acid.	betulinic acid	100-114	G protein-coupled bile acid receptor 1	Homo sapiens	53-57	
25283506-11	2014	CONCLUSION: This study demonstrates that highly lipophilic 3-epi-betulinic acid derivatives can be potent and selective TGR5 agonists with improved cellular efficacy, and our research here provides a new strategy for the design and development of potent TGR5 agonists.	betulinic acid	59-79	G protein-coupled bile acid receptor 1	Homo sapiens	120-124	
25283506-11	2014	CONCLUSION: This study demonstrates that highly lipophilic 3-epi-betulinic acid derivatives can be potent and selective TGR5 agonists with improved cellular efficacy, and our research here provides a new strategy for the design and development of potent TGR5 agonists.	betulinic acid	59-79	G protein-coupled bile acid receptor 1	Homo sapiens	254-258	
19911773-0	2010	Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.	betulinic acid	41-55	G protein-coupled bile acid receptor 1	Homo sapiens	79-83