PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26177448-9 2015 Betulinic acid, a selective GPBAR1 ligand, failed to rescue wild type and GPBAR1-/- mice from ANIT cholestasis but did not induced itching. betulinic acid 0-14 G protein-coupled bile acid receptor 1 Mus musculus 28-34 34406006-0 2021 Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5H88Y Mutant Mice. betulinic acid 18-32 G protein-coupled bile acid receptor 1 Mus musculus 55-59 34406006-2 2021 Herein, we identified a new series of betulinic acid derivatives as potent TGR5 agonists, which show remarkable activity on human (h) and canine (c) TGR5 but exhibit unpromising activity on murine (m) TGR5. betulinic acid 38-52 G protein-coupled bile acid receptor 1 Mus musculus 149-153 26179031-7 2015 Central infusion of the TGR5 agonist, betulinic acid, prior to AOM injection delayed neurological decline, increased cortical cyclic adenosine monophosphate concentrations, reduced microglia activation and proliferation, and reduced proinflammatory cytokine production. betulinic acid 38-52 G protein-coupled bile acid receptor 1 Mus musculus 24-28 26177448-6 2015 RESULTS: In naive mice skin application of DCA, TLCA, 6-ECDCA, oleanolic and betulinic acid induces a GPBAR1 dependent pruritogenic response that could be desensitized by re-challenging the mice with the same GPBAR1 agonist. betulinic acid 77-91 G protein-coupled bile acid receptor 1 Mus musculus 102-108 26177448-6 2015 RESULTS: In naive mice skin application of DCA, TLCA, 6-ECDCA, oleanolic and betulinic acid induces a GPBAR1 dependent pruritogenic response that could be desensitized by re-challenging the mice with the same GPBAR1 agonist. betulinic acid 77-91 G protein-coupled bile acid receptor 1 Mus musculus 209-215 30536462-9 2019 We screened the derivatives of betulinic acid (BA), a known TGR5 agonist, to identify novel dual agonists of FXR and TGR5. betulinic acid 31-45 G protein-coupled bile acid receptor 1 Mus musculus 60-64 30536462-9 2019 We screened the derivatives of betulinic acid (BA), a known TGR5 agonist, to identify novel dual agonists of FXR and TGR5. betulinic acid 31-45 G protein-coupled bile acid receptor 1 Mus musculus 117-121 30536462-9 2019 We screened the derivatives of betulinic acid (BA), a known TGR5 agonist, to identify novel dual agonists of FXR and TGR5. betulinic acid 47-49 G protein-coupled bile acid receptor 1 Mus musculus 60-64 30536462-9 2019 We screened the derivatives of betulinic acid (BA), a known TGR5 agonist, to identify novel dual agonists of FXR and TGR5. betulinic acid 47-49 G protein-coupled bile acid receptor 1 Mus musculus 117-121 25827806-7 2015 RESULTS: The selective TGR5 agonist BTA dose-dependently suppressed disease activity index and mRNA expression of the pro-inflammatory cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in the colon. betulinic acid 36-39 G protein-coupled bile acid receptor 1 Mus musculus 23-27 25827806-11 2015 CONCLUSION: The selective TGR5 agonist BTA ameliorated DSS-induced colitis in mice via the GLP-2 pathway with no effect of DPPIV inhibition, suggesting that other DPP enzymatic activity is involved in GLP-2 degradation. betulinic acid 39-42 G protein-coupled bile acid receptor 1 Mus musculus 26-30 22881598-8 2013 Treating GPBAR1(+/+) mice with two GPBAR1 agonists, ciprofloxacin and betulinic acid, rescued mice from gastric injury caused by ASA and NSAIDs. betulinic acid 70-84 G protein-coupled bile acid receptor 1 Mus musculus 9-15 22881598-8 2013 Treating GPBAR1(+/+) mice with two GPBAR1 agonists, ciprofloxacin and betulinic acid, rescued mice from gastric injury caused by ASA and NSAIDs. betulinic acid 70-84 G protein-coupled bile acid receptor 1 Mus musculus 35-41