PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26177448-9	2015	Betulinic acid, a selective GPBAR1 ligand, failed to rescue wild type and GPBAR1-/- mice from ANIT cholestasis but did not induced itching.	betulinic acid	0-14	G protein-coupled bile acid receptor 1	Mus musculus	28-34	
34406006-0	2021	Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5H88Y Mutant Mice.	betulinic acid	18-32	G protein-coupled bile acid receptor 1	Mus musculus	55-59	
34406006-2	2021	Herein, we identified a new series of betulinic acid derivatives as potent TGR5 agonists, which show remarkable activity on human (h) and canine (c) TGR5 but exhibit unpromising activity on murine (m) TGR5.	betulinic acid	38-52	G protein-coupled bile acid receptor 1	Mus musculus	149-153	
26179031-7	2015	Central infusion of the TGR5 agonist, betulinic acid, prior to AOM injection delayed neurological decline, increased cortical cyclic adenosine monophosphate concentrations, reduced microglia activation and proliferation, and reduced proinflammatory cytokine production.	betulinic acid	38-52	G protein-coupled bile acid receptor 1	Mus musculus	24-28	
26177448-6	2015	RESULTS: In naive mice skin application of DCA, TLCA, 6-ECDCA, oleanolic and betulinic acid induces a GPBAR1 dependent pruritogenic response that could be desensitized by re-challenging the mice with the same GPBAR1 agonist.	betulinic acid	77-91	G protein-coupled bile acid receptor 1	Mus musculus	102-108	
26177448-6	2015	RESULTS: In naive mice skin application of DCA, TLCA, 6-ECDCA, oleanolic and betulinic acid induces a GPBAR1 dependent pruritogenic response that could be desensitized by re-challenging the mice with the same GPBAR1 agonist.	betulinic acid	77-91	G protein-coupled bile acid receptor 1	Mus musculus	209-215	
30536462-9	2019	We screened the derivatives of betulinic acid (BA), a known TGR5 agonist, to identify novel dual agonists of FXR and TGR5.	betulinic acid	31-45	G protein-coupled bile acid receptor 1	Mus musculus	60-64	
30536462-9	2019	We screened the derivatives of betulinic acid (BA), a known TGR5 agonist, to identify novel dual agonists of FXR and TGR5.	betulinic acid	31-45	G protein-coupled bile acid receptor 1	Mus musculus	117-121	
30536462-9	2019	We screened the derivatives of betulinic acid (BA), a known TGR5 agonist, to identify novel dual agonists of FXR and TGR5.	betulinic acid	47-49	G protein-coupled bile acid receptor 1	Mus musculus	60-64	
30536462-9	2019	We screened the derivatives of betulinic acid (BA), a known TGR5 agonist, to identify novel dual agonists of FXR and TGR5.	betulinic acid	47-49	G protein-coupled bile acid receptor 1	Mus musculus	117-121	
25827806-7	2015	RESULTS: The selective TGR5 agonist BTA dose-dependently suppressed disease activity index and mRNA expression of the pro-inflammatory cytokines interleukin (IL)-1beta, IL-6, and tumor necrosis factor-alpha in the colon.	betulinic acid	36-39	G protein-coupled bile acid receptor 1	Mus musculus	23-27	
25827806-11	2015	CONCLUSION: The selective TGR5 agonist BTA ameliorated DSS-induced colitis in mice via the GLP-2 pathway with no effect of DPPIV inhibition, suggesting that other DPP enzymatic activity is involved in GLP-2 degradation.	betulinic acid	39-42	G protein-coupled bile acid receptor 1	Mus musculus	26-30	
22881598-8	2013	Treating GPBAR1(+/+) mice with two GPBAR1 agonists, ciprofloxacin and betulinic acid, rescued mice from gastric injury caused by ASA and NSAIDs.	betulinic acid	70-84	G protein-coupled bile acid receptor 1	Mus musculus	9-15	
22881598-8	2013	Treating GPBAR1(+/+) mice with two GPBAR1 agonists, ciprofloxacin and betulinic acid, rescued mice from gastric injury caused by ASA and NSAIDs.	betulinic acid	70-84	G protein-coupled bile acid receptor 1	Mus musculus	35-41