PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34374237-6 2021 Conclusion: At a final concentration of 10~30 mug/ml, betulinic acid can reduce the proliferation of human gastric cancer MGC-803 cells, inhibit cell growth, and down-regulate the expression of CCNB1 and CCND1 to block human gastric cancer MGC-803 cells in the S phase. betulinic acid 54-68 cyclin B1 Homo sapiens 194-199 34234893-4 2021 The down-regulation of cyclin A and cyclin B1, and up-regulation of cyclin-dependent kinase inhibitor p21WAF1/CIP1 revealed the G2/M phase arrest mechanism of BA. betulinic acid 159-161 cyclin B1 Homo sapiens 36-45 20037601-0 2010 Effect of betulinic acid on the regulation of Hiwi and cyclin B1 in human gastric adenocarcinoma AGS cells. betulinic acid 10-24 cyclin B1 Homo sapiens 55-64 20037601-9 2010 The expression of Hiwi and Cyclin B1 was down-regulated in BA-treated AGS cells in a dose-dependent manner. betulinic acid 59-61 cyclin B1 Homo sapiens 27-36 20037601-10 2010 CONCLUSION: BA exerted potent effect on growth inhibition, G(2)/M cell cycle arrest and induction of apoptosis in AGS cells in vitro, possibly associated with the down-regulation of Hiwi and its downstream target Cyclin B1 expression. betulinic acid 12-14 cyclin B1 Homo sapiens 213-222 33806566-5 2021 Furthermore, BA decreased the expression of cell cycle regulators, such as cyclin B1, cyclin A, cyclin-dependent kinase (Cdk) 2, cell division cycle (Cdc) 2, and Cdc25c. betulinic acid 13-15 cyclin B1 Homo sapiens 75-84 33719271-10 2020 Conclusion: The betulinic acid regulates the proliferation of SGC-7901 cells by inhibiting the expressions of cyclin D1 and cyclin B1, which leads to cell cycle arrest and proliferative inhibition. betulinic acid 16-30 cyclin B1 Homo sapiens 124-133