PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29423083-4 2018 In addition, BA could inhibit the activation of stat3 and FAK which resulted in a reduction of matrix metalloproteinases (MMPs), and increase of the MMPs inhibitor (TIMP-2) expression. betulinic acid 13-15 signal transducer and activator of transcription 3 Homo sapiens 48-53 21731766-0 2011 Suppression of STAT3 and HIF-1 alpha mediates anti-angiogenic activity of betulinic acid in hypoxic PC-3 prostate cancer cells. betulinic acid 74-88 signal transducer and activator of transcription 3 Homo sapiens 15-20 28331523-0 2017 Helicteric Acid, Oleanic Acid, and Betulinic Acid, Three Triterpenes from Helicteres angustifolia L., Inhibit Proliferation and Induce Apoptosis in HT-29 Colorectal Cancer Cells via Suppressing NF-kappaB and STAT3 Signaling. betulinic acid 35-49 signal transducer and activator of transcription 3 Homo sapiens 208-213 27748864-2 2016 The antitumor pharmacological effects of BA consist of triggering apoptosis via the mitochondrial pathway, regulating the cell cycle and the angiogenic pathway via factors, including specificity protein transcription factors, cyclin D1 and epidermal growth factor receptor, inhibiting the signal transducer and activator of transcription 3 and nuclear factor-kappaB signaling pathways, preventing the invasion and metastasis of tumor cells, and affecting the expression of topoisomerase I, p53 and lamin B1. betulinic acid 41-43 signal transducer and activator of transcription 3 Homo sapiens 289-339 21731766-2 2011 In the present study, we examined that betulinic acid (BA), a triterpene from the bark of white birch, had the inhibitory effects on hypoxia-mediated activation of STAT3 in androgen independent human prostate cancer PC-3 cells. betulinic acid 39-53 signal transducer and activator of transcription 3 Homo sapiens 164-169 21731766-2 2011 In the present study, we examined that betulinic acid (BA), a triterpene from the bark of white birch, had the inhibitory effects on hypoxia-mediated activation of STAT3 in androgen independent human prostate cancer PC-3 cells. betulinic acid 55-57 signal transducer and activator of transcription 3 Homo sapiens 164-169 21731766-4 2011 Consistently, BA blocked hypoxia-induced phosphorylation, DNA binding activity and nuclear accumulation of STAT3. betulinic acid 14-16 signal transducer and activator of transcription 3 Homo sapiens 107-112 21731766-5 2011 In addition, BA significantly reduced cellular and secreted levels of vascular endothelial growth factor (VEGF), a critical angiogenic factor and a target gene of STAT3 induced under hypoxia. betulinic acid 13-15 signal transducer and activator of transcription 3 Homo sapiens 163-168 21731766-7 2011 Of note, chromatin immunoprecipitation (ChiP) assay revealed that BA inhibited binding of HIF-1alpha and STAT3 to VEGF promoter. betulinic acid 66-68 signal transducer and activator of transcription 3 Homo sapiens 105-110 19937797-0 2010 Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP-1 in human multiple myeloma cells. betulinic acid 0-14 signal transducer and activator of transcription 3 Homo sapiens 26-31 19937797-2 2010 Whether betulinic acid, a pentacyclic triterpene, can modulate the STAT3 pathway, was investigated in human multiple myeloma (MM) cells. betulinic acid 8-22 signal transducer and activator of transcription 3 Homo sapiens 67-72 19937797-3 2010 We found that betulinic acid inhibited constitutive activation of STAT3, Src kinase, JAK1 and JAK2. betulinic acid 14-28 signal transducer and activator of transcription 3 Homo sapiens 66-71 19937797-4 2010 Pervanadate reversed the betulinic acid-induced downregulation of STAT3 activation, suggesting the involvement of a protein tyrosine phosphatase (PTP). betulinic acid 25-39 signal transducer and activator of transcription 3 Homo sapiens 66-71 19937797-5 2010 Furthermore, betulinic acid induced the expression of the PTP SHP-1 and silencing of the SHP-1 gene abolished the ability of betulinic acid to inhibit STAT3 activation and rescued betulinic acid-induced cell death. betulinic acid 13-27 signal transducer and activator of transcription 3 Homo sapiens 151-156 19937797-5 2010 Furthermore, betulinic acid induced the expression of the PTP SHP-1 and silencing of the SHP-1 gene abolished the ability of betulinic acid to inhibit STAT3 activation and rescued betulinic acid-induced cell death. betulinic acid 125-139 signal transducer and activator of transcription 3 Homo sapiens 151-156 19937797-5 2010 Furthermore, betulinic acid induced the expression of the PTP SHP-1 and silencing of the SHP-1 gene abolished the ability of betulinic acid to inhibit STAT3 activation and rescued betulinic acid-induced cell death. betulinic acid 125-139 signal transducer and activator of transcription 3 Homo sapiens 151-156 19937797-6 2010 Betulinic acid also downregulated the expression of STAT3-regulated gene products such as bcl-xL, bcl-2, cyclin D1 and survivin. betulinic acid 0-14 signal transducer and activator of transcription 3 Homo sapiens 52-57 19937797-8 2010 Consistent with these results, overexpression of constitutive active STAT3 significantly reduced the betulinic acid-induced apoptosis. betulinic acid 101-115 signal transducer and activator of transcription 3 Homo sapiens 69-74 19937797-10 2010 Overall, our results suggest that betulinic acid downregulates STAT3 activation through upregulation of SHP-1, and this may have potential in sensitization of STAT3 overexpressing tumors to chemotherapeutic agents. betulinic acid 34-48 signal transducer and activator of transcription 3 Homo sapiens 63-68 19937797-10 2010 Overall, our results suggest that betulinic acid downregulates STAT3 activation through upregulation of SHP-1, and this may have potential in sensitization of STAT3 overexpressing tumors to chemotherapeutic agents. betulinic acid 34-48 signal transducer and activator of transcription 3 Homo sapiens 159-164 34388528-2 2021 BA has antitumour activity, and its mechanisms of action mainly include the induction of mitochondrial oxidative stress; the regulation of specificity protein transcription factors, and the inhibition of signal transducer and activator of transcription 3 and nuclear factor-kappaB signalling pathways. betulinic acid 0-2 signal transducer and activator of transcription 3 Homo sapiens 204-254