PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28578903-3	2017	The isolate, BA, which produced an encouraging cytotoxic effect against non-small lung cancer cells (A549 and NCI-H1299) through the MTT assay, was further assessed with TUNEL, Sub-G1 population quantification, acridine orange/ethidium bromide staining as well as activated caspase-3 detection.	betulinic acid	13-15	caspase 3	Homo sapiens	274-283	
29438593-3	2018	Betulinic acid, thapsigargin, and the calcium ionophore treatment resulted in an increased number of sperm cells with caspase 9 and caspase 3 activation, disrupted mitochondrial membrane potential, and a reacted acrosome.	betulinic acid	0-14	caspase 3	Homo sapiens	132-141	
28109089-5	2017	In addition, BA significantly promoted mitochondrial apoptosis, as reflected by an increase in TUNEL+ cells and the activities of caspases 3 and 9, an increase in Bax expression, and a decrease in Bcl-2 expression and the mitochondrial oxygen consumption rate.	betulinic acid	13-15	caspase 3	Homo sapiens	130-146	
23064721-7	2012	BA treatment dose-dependently induced apoptosis of KM3 cells, which was associated with the activation of caspase 3.	betulinic acid	0-2	caspase 3	Homo sapiens	106-115	
20714869-8	2010	The proportion of cells in G0/G1 and G2/M phases was decreased and that in S phase was increased after K562 cells were treated with BA for 24 h. BA treatment also increased the expression of the pro-apoptotic proteins Bax and caspase-3.	betulinic acid	132-134	caspase 3	Homo sapiens	226-235	
20714869-8	2010	The proportion of cells in G0/G1 and G2/M phases was decreased and that in S phase was increased after K562 cells were treated with BA for 24 h. BA treatment also increased the expression of the pro-apoptotic proteins Bax and caspase-3.	betulinic acid	145-147	caspase 3	Homo sapiens	226-235	
20714869-10	2010	The antitumor effects of BA were related with up-regulation of the expression of Bax and caspase-3 proteins.	betulinic acid	25-27	caspase 3	Homo sapiens	89-98	
20451375-4	2010	Caspase 3 activity on lung cancer cell line (A549) was determined for 1, 5 (3-O-ethylcarbamate of betulinic acid), 9 and 11.	betulinic acid	98-112	caspase 3	Homo sapiens	0-9	
34816660-8	2021	Conclusion: Within a certain range of concentrations, betulinic acid induces cell apoptosis by regulating the expression of Bcl-2, Bax and Caspase-3 in human gastric cancer.	betulinic acid	54-68	caspase 3	Homo sapiens	139-148	
19840455-8	2009	RT-PCR detection of caspase 3 gene indicated that its transcription level showed an increasing trend as the concentration of betulinic acid increased, while the bcl-xl showed the opposite trend.	betulinic acid	125-139	caspase 3	Homo sapiens	20-29	
9766678-6	1998	Mitochondria from cells treated with either Doxo or Bet A induced cleavage of both caspase-8 and caspase-3 in cytosolic extracts.	betulinic acid	52-57	caspase 3	Homo sapiens	97-106	
19465458-7	2009	To elucidate the caspase dependency of BA-triggered disruption of DeltaPsi(m), we used the pan-caspase inhibitor zVAD-fmk and the caspase-3/7 inhibitor DEVD-cho.	betulinic acid	39-41	caspase 3	Homo sapiens	130-139	
19465458-8	2009	RESULTS: Exposing highly motile sperm to BA caused a specific disruption of DeltaPsi(m) (P < 0.001 versus control) and a corresponding increase in caspase-3/7 activity (P < 0.001 versus control).	betulinic acid	41-43	caspase 3	Homo sapiens	150-159	
33806566-7	2021	BA up-regulated the expression of Bcl-2-accociated X protein (Bax) and cleaved poly-ADP ribose polymerase (PARP), and subsequently activated caspase-3, -8, and -9.	betulinic acid	0-2	caspase 3	Homo sapiens	141-162	
35225471-9	2022	Quantitative real-time PCR analysis demonstrated that BA increased p53, Bax and caspase-3 expression whilst it decreased Bcl-2 expression in the HuCCA cells in a dose dependent manner.	betulinic acid	54-56	caspase 3	Homo sapiens	80-89	
34374264-9	2021	Conclusion: In the final concentration range of 10 ~ 30 mug/ml, betulinic acid can induce apoptosis of human gastric cancer MGC-803 cells by regulating the expression of Caspase-3, Caspase-9 and Cyt c.	betulinic acid	64-78	caspase 3	Homo sapiens	170-179	
33251156-6	2020	Similarly, the population of Sox2+ and Casp3+ NPCs found in ZIKV-infected cerebral organoids was significantly higher in the presence of BA than in untreated controls.	betulinic acid	137-139	caspase 3	Homo sapiens	39-44	
32368052-12	2020	We concluded that one of the important mechanisms of BA-C60(OH)n-GBP-TPGS-NPs inhibiting MHCC97H cells is achieved by up-regulating the expression of Caspase-3, Caspase-8 and Caspase-9.	betulinic acid	53-55	caspase 3	Homo sapiens	150-159