PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35489292-0 2022 Ameliorative effect of betulinic acid against zearalenone exposure triggers testicular dysfunction and oxidative stress in mice via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation. betulinic acid 23-37 nuclear factor, erythroid derived 2, like 2 Mus musculus 160-164 35489292-6 2022 Moreover, BA alleviated ZEA-exposed testicular oxidative stress by activating Nrf2 pathway. betulinic acid 10-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 78-82 34482064-0 2021 Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-kappaB/MAPK signalling pathways and activating the Nrf2 signalling pathway. betulinic acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 148-152 34482064-5 2021 Moreover, BA treatment suppressed the CYP-induced oxidative stress by activating the nuclear factor erythroid 2 (NF-E2)-related factor (Nrf2) pathway blocked reactive oxygen species (ROS) accumulation. betulinic acid 10-12 nuclear factor, erythroid derived 2, like 2 Mus musculus 136-140 34482064-8 2021 Overall, the current study demonstrated the protective effect of BA against CYP-caused intestinal mucosal damage by regulating the Nrf2 and NF-kappaB/MAPK signalling pathways, which may provide new therapeutic targets to attenuate intestinal impairment and maintain intestinal health. betulinic acid 65-67 nuclear factor, erythroid derived 2, like 2 Mus musculus 131-135 34628148-0 2021 Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice. betulinic acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 101-105 34628148-7 2021 Furthermore, mechanism research found that pretreatment with BA could activate Nrf2 signaling pathway. betulinic acid 61-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 79-83 34628148-8 2021 It was suggested that BA ameliorated the oxidative stress and inflammatory response of T-2 toxin-triggered renal damage by activating the Nrf2 signaling pathway. betulinic acid 22-24 nuclear factor, erythroid derived 2, like 2 Mus musculus 138-142 35489292-8 2022 Overall, our results revealed that BA has a therapeutic protective effect on ZEA-induced testicular injury and oxidative stress via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation, which provides a viable alternative to alleviate ZEA-induced male reproductive toxicology. betulinic acid 35-37 nuclear factor, erythroid derived 2, like 2 Mus musculus 160-164 33499152-0 2021 Betulinic Acid Alleviates Spleen Oxidative Damage Induced by Acute Intraperitoneal Exposure to T-2 Toxin by Activating Nrf2 and Inhibiting MAPK Signaling Pathways. betulinic acid 0-14 nuclear factor, erythroid derived 2, like 2 Mus musculus 119-123 33499152-7 2021 Furthermore, administration of BA alleviated the protein phosphorylation of p38, c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinases (ERK); decreased the protein expression of kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein1 (Keap1); and increased the protein expression of nuclear factor erythroid 2 [NF-E2]-related factor (Nrf2) and heme oxygenase-1 (HO-1) in the spleen. betulinic acid 31-33 nuclear factor, erythroid derived 2, like 2 Mus musculus 384-388 33499152-8 2021 These findings demonstrate that BA defends against spleen oxidative damage associated with T-2 toxin injection by decreasing ROS accumulation and activating the Nrf2 signaling pathway, as well as inhibiting the mitogen-activated protein kinase (MAPK) signaling pathway. betulinic acid 32-34 nuclear factor, erythroid derived 2, like 2 Mus musculus 161-165