PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35489292-0	2022	Ameliorative effect of betulinic acid against zearalenone exposure triggers testicular dysfunction and oxidative stress in mice via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation.	betulinic acid	23-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	160-164	
34628148-0	2021	Betulinic acid protects against renal damage by attenuation of oxidative stress and inflammation via Nrf2 signaling pathway in T-2 toxin-induced mice.	betulinic acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-105	
34628148-7	2021	Furthermore, mechanism research found that pretreatment with BA could activate Nrf2 signaling pathway.	betulinic acid	61-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	79-83	
34628148-8	2021	It was suggested that BA ameliorated the oxidative stress and inflammatory response of T-2 toxin-triggered renal damage by activating the Nrf2 signaling pathway.	betulinic acid	22-24	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142	
34482064-0	2021	Betulinic acid attenuates cyclophosphamide-induced intestinal mucosa injury by inhibiting the NF-kappaB/MAPK signalling pathways and activating the Nrf2 signalling pathway.	betulinic acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	148-152	
34482064-5	2021	Moreover, BA treatment suppressed the CYP-induced oxidative stress by activating the nuclear factor erythroid 2 (NF-E2)-related factor (Nrf2) pathway blocked reactive oxygen species (ROS) accumulation.	betulinic acid	10-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	136-140	
34482064-8	2021	Overall, the current study demonstrated the protective effect of BA against CYP-caused intestinal mucosal damage by regulating the Nrf2 and NF-kappaB/MAPK signalling pathways, which may provide new therapeutic targets to attenuate intestinal impairment and maintain intestinal health.	betulinic acid	65-67	nuclear factor, erythroid derived 2, like 2	Mus musculus	131-135	
35489292-8	2022	Overall, our results revealed that BA has a therapeutic protective effect on ZEA-induced testicular injury and oxidative stress via p38/ERK MAPK inhibition and Nrf2-mediated antioxidant defense activation, which provides a viable alternative to alleviate ZEA-induced male reproductive toxicology.	betulinic acid	35-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	160-164	
35489292-6	2022	Moreover, BA alleviated ZEA-exposed testicular oxidative stress by activating Nrf2 pathway.	betulinic acid	10-12	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82	
33499152-0	2021	Betulinic Acid Alleviates Spleen Oxidative Damage Induced by Acute Intraperitoneal Exposure to T-2 Toxin by Activating Nrf2 and Inhibiting MAPK Signaling Pathways.	betulinic acid	0-14	nuclear factor, erythroid derived 2, like 2	Mus musculus	119-123	
33499152-7	2021	Furthermore, administration of BA alleviated the protein phosphorylation of p38, c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinases (ERK); decreased the protein expression of kelch-like erythroid cell-derived protein with CNC homology [ECH]-associated protein1 (Keap1); and increased the protein expression of nuclear factor erythroid 2 [NF-E2]-related factor (Nrf2) and heme oxygenase-1 (HO-1) in the spleen.	betulinic acid	31-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	384-388	
33499152-8	2021	These findings demonstrate that BA defends against spleen oxidative damage associated with T-2 toxin injection by decreasing ROS accumulation and activating the Nrf2 signaling pathway, as well as inhibiting the mitogen-activated protein kinase (MAPK) signaling pathway.	betulinic acid	32-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	161-165