PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17496167-0	2007	Reciprocal regulation of endothelial nitric-oxide synthase and NADPH oxidase by betulinic acid in human endothelial cells.	betulinic acid	80-94	nitric oxide synthase 3	Homo sapiens	25-58	
17496167-7	2007	Jujuboside A, jujuboside B, or betulin had no significant effect on eNOS expression, whereas betulinic acid increased eNOS mRNA and protein expression in HUVEC and EA.hy 926 cells.	betulinic acid	93-107	nitric oxide synthase 3	Homo sapiens	118-122	
17496167-8	2007	Interestingly, betulinic acid also attenuated the expression of NADPH oxidase subunits Nox4 and p22phox, thereby reducing oxidative stress and improving eNOS function.	betulinic acid	15-29	nitric oxide synthase 3	Homo sapiens	153-157	
17496167-10	2007	Thus, betulinic acid possesses combined properties of eNOS up-regulation and NADPH oxidase down-regulation.	betulinic acid	6-20	nitric oxide synthase 3	Homo sapiens	54-58	
33232606-0	2020	Betulinic Acid Induces eNOS Expression via the AMPK-Dependent KLF2 Signaling Pathway.	betulinic acid	0-14	nitric oxide synthase 3	Homo sapiens	23-27	
33232606-2	2020	We have previously shown that BA prevents endothelial dysfunction by increasing nitric oxide (NO) synthesis through activating endothelial nitric oxide synthase (eNOS) in human endothelial cells.	betulinic acid	30-32	nitric oxide synthase 3	Homo sapiens	127-160	
33232606-2	2020	We have previously shown that BA prevents endothelial dysfunction by increasing nitric oxide (NO) synthesis through activating endothelial nitric oxide synthase (eNOS) in human endothelial cells.	betulinic acid	30-32	nitric oxide synthase 3	Homo sapiens	162-166	
33232606-3	2020	However, the effect of BA on eNOS expression remains unclear.	betulinic acid	23-25	nitric oxide synthase 3	Homo sapiens	29-33	
33232606-4	2020	Thus, the aim of our study was to investigate the intracellular pathways associated with the effect of BA to regulate eNOS expression in human endothelial cells.	betulinic acid	103-105	nitric oxide synthase 3	Homo sapiens	118-122	
33232606-5	2020	BA significantly increased eNOS expression in a time- and concentration-dependent manner.	betulinic acid	0-2	nitric oxide synthase 3	Homo sapiens	27-31	
33232606-6	2020	Additionally, BA upregulated the expression of the transcription factor KLF2, which is known to regulate eNOS expression.	betulinic acid	14-16	nitric oxide synthase 3	Homo sapiens	105-109	
33232606-7	2020	KLF2 silencing in human endothelial cells attenuated the ability of BA to upregulate eNOS.	betulinic acid	68-70	nitric oxide synthase 3	Homo sapiens	85-89	
27463705-0	2016	Estrogen Receptor Signaling and the PI3K/Akt Pathway Are Involved in Betulinic Acid-Induced eNOS Activation.	betulinic acid	69-83	nitric oxide synthase 3	Homo sapiens	92-96	
27463705-6	2016	Short-term incubation of EA.hy 926 cells with BA resulted in eNOS phosphorylation at the serine 1177 residue in a concentration- and time-dependent manner with a half-maximal effective concentration of 0.57 microM.	betulinic acid	46-48	nitric oxide synthase 3	Homo sapiens	61-65	
27463705-8	2016	BA-induced eNOS phosphorylation and NO production was completely blocked by pretreatment with ICI 182,780, and was attenuated by pretreatment with the PI3K inhibitors wortmannin and LY294002.	betulinic acid	0-2	nitric oxide synthase 3	Homo sapiens	11-15	
27463705-9	2016	These results indicate that fast non-genomic effects of ER with downstream signaling through the PI3K/Akt pathway and consecutive eNOS phosphorylation at serine 1177 are involved in BA-induced eNOS activation.	betulinic acid	182-184	nitric oxide synthase 3	Homo sapiens	130-134	
27463705-9	2016	These results indicate that fast non-genomic effects of ER with downstream signaling through the PI3K/Akt pathway and consecutive eNOS phosphorylation at serine 1177 are involved in BA-induced eNOS activation.	betulinic acid	182-184	nitric oxide synthase 3	Homo sapiens	193-197	
26750873-1	2016	Betulinic acid (BA) is a naturally occurring pentacyclic triterpene that attenuates vascular diseases and atherosclerosis, but the mechanism by which it stimulates endothelial nitric oxide synthase (eNOS) is unclear.	betulinic acid	0-14	nitric oxide synthase 3	Homo sapiens	164-197	
26750873-1	2016	Betulinic acid (BA) is a naturally occurring pentacyclic triterpene that attenuates vascular diseases and atherosclerosis, but the mechanism by which it stimulates endothelial nitric oxide synthase (eNOS) is unclear.	betulinic acid	16-18	nitric oxide synthase 3	Homo sapiens	164-197