PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10336521-7 1999 Ectopic expression of BCL-2 prevents BA-induced caspase activation, DNA fragmentation, and cell death. betulinic acid 37-39 BCL2 apoptosis regulator Homo sapiens 22-27 12953308-6 2003 Western blot analysis of the expression of various Bcl-2 family members in betulinic acid-treated cells showed, surprisingly, a suppression of the expression of the proapoptotic protein Bax but no changes in Mcl-1 or Bcl-2 expression. betulinic acid 75-89 BCL2 apoptosis regulator Homo sapiens 51-56 10771474-7 2000 Notably, despite the induction of apoptosis, analysis of the expression of Bcl-2 family members in betulinic-acid-treated cells revealed that expression of the anti-apoptotic protein Mcl-1 was induced. betulinic acid 99-113 BCL2 apoptosis regulator Homo sapiens 75-80 10336521-9 1999 The generation of reactive oxygen species is blocked by BCL-2 and requires new protein synthesis but is unaffected by caspase inhibitors, suggesting that BA toxicity sequentially involves new protein synthesis, formation of reactive oxygen species, and activation of crm-A-insensitive caspases. betulinic acid 154-156 BCL2 apoptosis regulator Homo sapiens 56-61 35225471-9 2022 Quantitative real-time PCR analysis demonstrated that BA increased p53, Bax and caspase-3 expression whilst it decreased Bcl-2 expression in the HuCCA cells in a dose dependent manner. betulinic acid 54-56 BCL2 apoptosis regulator Homo sapiens 121-126 34234893-5 2021 In addition, BA induced the cytosolic release of cytochrome c by reducing the mitochondrial membrane potential with an increasing Bax/Bcl-2 expression ratio. betulinic acid 13-15 BCL2 apoptosis regulator Homo sapiens 134-139 9354463-7 1997 Overexpression of Bcl-2 and Bcl-XL conferred resistance to BA at the level of mitochondrial dysfunction, protease activation, and nuclear fragmentation. betulinic acid 59-61 BCL2 apoptosis regulator Homo sapiens 18-23 9354463-9 1997 Furthermore, Bax and Bcl-xs, two death-promoting proteins of the Bcl-2 family, were up-regulated following BA treatment. betulinic acid 107-109 BCL2 apoptosis regulator Homo sapiens 65-70 34770786-7 2021 Pro-apoptotic markers including Bax, cleaved-caspase-3 and cleaved-caspase-9 were increased while anti-apoptotic marker Bcl-2 was decreased after BA treatment. betulinic acid 146-148 BCL2 apoptosis regulator Homo sapiens 120-125 34816660-8 2021 Conclusion: Within a certain range of concentrations, betulinic acid induces cell apoptosis by regulating the expression of Bcl-2, Bax and Caspase-3 in human gastric cancer. betulinic acid 54-68 BCL2 apoptosis regulator Homo sapiens 124-129 32513155-0 2020 Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer. betulinic acid 26-40 BCL2 apoptosis regulator Homo sapiens 60-64 33902540-0 2021 Correction to: Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer. betulinic acid 41-55 BCL2 apoptosis regulator Homo sapiens 75-79 32277808-11 2020 Western blotting of HKULC2 cells showed that betulinic acid nanoparticles promoted the expression of p21 and p53 and downregulated CD133, ALDH, BCL2, MCL1, and c-Myc expression. betulinic acid 45-59 BCL2 apoptosis regulator Homo sapiens 144-148 31277238-8 2019 The results indicated that the expression levels of cleaved caspase-8, -3, -9, and Bax were increased in A2780 cells treated with betulinic acid, whereas those of Bcl-2 were decreased. betulinic acid 130-144 BCL2 apoptosis regulator Homo sapiens 163-168 30127971-6 2018 The effects of betulinic acid on the protein expression of B-cell lymphoma-2 (Bcl-2)/Bcl-2-associated X (Bax) were evaluated by western blot analysis. betulinic acid 15-29 BCL2 apoptosis regulator Homo sapiens 59-76 30910472-6 2019 Moreover, BA could induce cell apoptosis by upregulating expression of Bax and cleaved caspase-3 and downregulating protein of Bcl-2. betulinic acid 10-12 BCL2 apoptosis regulator Homo sapiens 127-132 30417527-6 2019 Moreover, western blot analysis showed that BA-induced apoptosis associated with increasing of pro-apoptotic protein Bax and cleaved caspase-3 and decreasing of anti-apoptotic protein Bcl-2. betulinic acid 44-46 BCL2 apoptosis regulator Homo sapiens 184-189 30127971-6 2018 The effects of betulinic acid on the protein expression of B-cell lymphoma-2 (Bcl-2)/Bcl-2-associated X (Bax) were evaluated by western blot analysis. betulinic acid 15-29 BCL2 apoptosis regulator Homo sapiens 78-83 30127971-6 2018 The effects of betulinic acid on the protein expression of B-cell lymphoma-2 (Bcl-2)/Bcl-2-associated X (Bax) were evaluated by western blot analysis. betulinic acid 15-29 BCL2 apoptosis regulator Homo sapiens 85-90 30127971-10 2018 The betulinic acid exerted anticancer activity via the induction of apoptosis by regulating the Bcl-2/Bax signaling pathway. betulinic acid 4-18 BCL2 apoptosis regulator Homo sapiens 96-101 28109089-5 2017 In addition, BA significantly promoted mitochondrial apoptosis, as reflected by an increase in TUNEL+ cells and the activities of caspases 3 and 9, an increase in Bax expression, and a decrease in Bcl-2 expression and the mitochondrial oxygen consumption rate. betulinic acid 13-15 BCL2 apoptosis regulator Homo sapiens 197-202 25148076-9 2014 Furthermore, it was found that the antiapoptotic bcl-2 gene was down-regulated while the proapoptotic bax gene was up-regulated after betulinic acid treatment in HeLa cells. betulinic acid 134-148 BCL2 apoptosis regulator Homo sapiens 49-54 28208611-6 2017 Inhibition of cell survival by BA at 10 and 20 microM concentrations occurred as a result of alteration in Bax/Bcl-2 ratio in both cell lines that led to an increased cytochrome C release, caspase activation and poly(ADP)ribose polymerase (PARP) cleavage, leading to apoptosis. betulinic acid 31-33 BCL2 apoptosis regulator Homo sapiens 111-116 21355282-12 2010 CONCLUSION: BA exerted potent effect on growth inhibition, G0 cell cycle arrest and induction of apoptosis in BxPC-3 cells in vitro, possibly associated with the down-regulation of Bcl-2 and up-regulation of Bax expression. betulinic acid 12-14 BCL2 apoptosis regulator Homo sapiens 181-186 19937797-6 2010 Betulinic acid also downregulated the expression of STAT3-regulated gene products such as bcl-xL, bcl-2, cyclin D1 and survivin. betulinic acid 0-14 BCL2 apoptosis regulator Homo sapiens 98-103