PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22526391-0 2012 Betulinic acid induces Bax/Bak-independent cytochrome c release in human nasopharyngeal carcinoma cells. betulinic acid 0-14 BCL2 associated X, apoptosis regulator Homo sapiens 23-26 30910472-6 2019 Moreover, BA could induce cell apoptosis by upregulating expression of Bax and cleaved caspase-3 and downregulating protein of Bcl-2. betulinic acid 10-12 BCL2 associated X, apoptosis regulator Homo sapiens 71-74 30417527-6 2019 Moreover, western blot analysis showed that BA-induced apoptosis associated with increasing of pro-apoptotic protein Bax and cleaved caspase-3 and decreasing of anti-apoptotic protein Bcl-2. betulinic acid 44-46 BCL2 associated X, apoptosis regulator Homo sapiens 117-120 28109089-5 2017 In addition, BA significantly promoted mitochondrial apoptosis, as reflected by an increase in TUNEL+ cells and the activities of caspases 3 and 9, an increase in Bax expression, and a decrease in Bcl-2 expression and the mitochondrial oxygen consumption rate. betulinic acid 13-15 BCL2 associated X, apoptosis regulator Homo sapiens 163-166 28208611-6 2017 Inhibition of cell survival by BA at 10 and 20 microM concentrations occurred as a result of alteration in Bax/Bcl-2 ratio in both cell lines that led to an increased cytochrome C release, caspase activation and poly(ADP)ribose polymerase (PARP) cleavage, leading to apoptosis. betulinic acid 31-33 BCL2 associated X, apoptosis regulator Homo sapiens 107-110 25148076-9 2014 Furthermore, it was found that the antiapoptotic bcl-2 gene was down-regulated while the proapoptotic bax gene was up-regulated after betulinic acid treatment in HeLa cells. betulinic acid 134-148 BCL2 associated X, apoptosis regulator Homo sapiens 102-105 32513155-0 2020 Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer. betulinic acid 26-40 BCL2 associated X, apoptosis regulator Homo sapiens 65-68 31277238-8 2019 The results indicated that the expression levels of cleaved caspase-8, -3, -9, and Bax were increased in A2780 cells treated with betulinic acid, whereas those of Bcl-2 were decreased. betulinic acid 130-144 BCL2 associated X, apoptosis regulator Homo sapiens 83-86 30127971-6 2018 The effects of betulinic acid on the protein expression of B-cell lymphoma-2 (Bcl-2)/Bcl-2-associated X (Bax) were evaluated by western blot analysis. betulinic acid 15-29 BCL2 associated X, apoptosis regulator Homo sapiens 105-108 30127971-10 2018 The betulinic acid exerted anticancer activity via the induction of apoptosis by regulating the Bcl-2/Bax signaling pathway. betulinic acid 4-18 BCL2 associated X, apoptosis regulator Homo sapiens 102-105 25893306-3 2016 Betulinic acid (BetA) is a natural compound that selectively kills tumour cells through an ill-defined mechanism that is independent of BAX and BAK, but depends on mitochondrial permeability transition-pore opening. betulinic acid 0-14 BCL2 associated X, apoptosis regulator Homo sapiens 136-139 25893306-3 2016 Betulinic acid (BetA) is a natural compound that selectively kills tumour cells through an ill-defined mechanism that is independent of BAX and BAK, but depends on mitochondrial permeability transition-pore opening. betulinic acid 16-20 BCL2 associated X, apoptosis regulator Homo sapiens 136-139 21355282-12 2010 CONCLUSION: BA exerted potent effect on growth inhibition, G0 cell cycle arrest and induction of apoptosis in BxPC-3 cells in vitro, possibly associated with the down-regulation of Bcl-2 and up-regulation of Bax expression. betulinic acid 12-14 BCL2 associated X, apoptosis regulator Homo sapiens 208-211 21751259-0 2011 Co-treatment with ginsenoside Rh2 and betulinic acid synergistically induces apoptosis in human cancer cells in association with enhanced capsase-8 activation, bax translocation, and cytochrome c release. betulinic acid 38-52 BCL2 associated X, apoptosis regulator Homo sapiens 160-163 21751259-2 2011 G-Rh2 and Bet A cooperated to induce Bax traslocation to mitochondria and cytochrome c release. betulinic acid 10-15 BCL2 associated X, apoptosis regulator Homo sapiens 37-40 20714869-8 2010 The proportion of cells in G0/G1 and G2/M phases was decreased and that in S phase was increased after K562 cells were treated with BA for 24 h. BA treatment also increased the expression of the pro-apoptotic proteins Bax and caspase-3. betulinic acid 132-134 BCL2 associated X, apoptosis regulator Homo sapiens 218-221 20714869-8 2010 The proportion of cells in G0/G1 and G2/M phases was decreased and that in S phase was increased after K562 cells were treated with BA for 24 h. BA treatment also increased the expression of the pro-apoptotic proteins Bax and caspase-3. betulinic acid 145-147 BCL2 associated X, apoptosis regulator Homo sapiens 218-221 20714869-10 2010 The antitumor effects of BA were related with up-regulation of the expression of Bax and caspase-3 proteins. betulinic acid 25-27 BCL2 associated X, apoptosis regulator Homo sapiens 81-84 17620440-3 2007 Here, we describe six BA derivatives that are markedly more potent than BA for inhibiting inducible nitric oxide synthase, activating phase 2 cytoprotective enzymes, and inducing apoptosis in cancer cells and in Bax/Bak(-/-) fibroblasts, which lack two key proteins involved in the intrinsic, mitochondrial-dependent apoptotic pathway. betulinic acid 22-24 BCL2 associated X, apoptosis regulator Homo sapiens 212-215 19115109-0 2009 Betulinic acid induces cytochrome c release and apoptosis in a Bax/Bak-independent, permeability transition pore dependent fashion. betulinic acid 0-14 BCL2 associated X, apoptosis regulator Homo sapiens 63-66 12953308-6 2003 Western blot analysis of the expression of various Bcl-2 family members in betulinic acid-treated cells showed, surprisingly, a suppression of the expression of the proapoptotic protein Bax but no changes in Mcl-1 or Bcl-2 expression. betulinic acid 75-89 BCL2 associated X, apoptosis regulator Homo sapiens 186-189 34770786-7 2021 Pro-apoptotic markers including Bax, cleaved-caspase-3 and cleaved-caspase-9 were increased while anti-apoptotic marker Bcl-2 was decreased after BA treatment. betulinic acid 146-148 BCL2 associated X, apoptosis regulator Homo sapiens 32-35 33806566-7 2021 BA up-regulated the expression of Bcl-2-accociated X protein (Bax) and cleaved poly-ADP ribose polymerase (PARP), and subsequently activated caspase-3, -8, and -9. betulinic acid 0-2 BCL2 associated X, apoptosis regulator Homo sapiens 34-60 33806566-7 2021 BA up-regulated the expression of Bcl-2-accociated X protein (Bax) and cleaved poly-ADP ribose polymerase (PARP), and subsequently activated caspase-3, -8, and -9. betulinic acid 0-2 BCL2 associated X, apoptosis regulator Homo sapiens 62-65 9354463-9 1997 Furthermore, Bax and Bcl-xs, two death-promoting proteins of the Bcl-2 family, were up-regulated following BA treatment. betulinic acid 107-109 BCL2 associated X, apoptosis regulator Homo sapiens 13-16 34064489-6 2021 In addition, BA triggered a dose-dependent cytotoxic effect characterized by apoptotic features: morphological alterations (nuclear fragmentation, apoptotic bodies) and the upregulation of pro-apoptotic markers mRNA expression (Bax, Bad and Bak). betulinic acid 13-15 BCL2 associated X, apoptosis regulator Homo sapiens 228-231 34816660-8 2021 Conclusion: Within a certain range of concentrations, betulinic acid induces cell apoptosis by regulating the expression of Bcl-2, Bax and Caspase-3 in human gastric cancer. betulinic acid 54-68 BCL2 associated X, apoptosis regulator Homo sapiens 131-134 34234893-5 2021 In addition, BA induced the cytosolic release of cytochrome c by reducing the mitochondrial membrane potential with an increasing Bax/Bcl-2 expression ratio. betulinic acid 13-15 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 33902540-0 2021 Correction to: Chemopreventive effect of Betulinic acid via mTOR -Caspases/Bcl2/Bax apoptotic signaling in pancreatic cancer. betulinic acid 41-55 BCL2 associated X, apoptosis regulator Homo sapiens 80-83 35225471-9 2022 Quantitative real-time PCR analysis demonstrated that BA increased p53, Bax and caspase-3 expression whilst it decreased Bcl-2 expression in the HuCCA cells in a dose dependent manner. betulinic acid 54-56 BCL2 associated X, apoptosis regulator Homo sapiens 72-75