PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29423083-4	2018	In addition, BA could inhibit the activation of stat3 and FAK which resulted in a reduction of matrix metalloproteinases (MMPs), and increase of the MMPs inhibitor (TIMP-2) expression.	betulinic acid	13-15	matrix metallopeptidase 2	Homo sapiens	122-126	
29423083-4	2018	In addition, BA could inhibit the activation of stat3 and FAK which resulted in a reduction of matrix metalloproteinases (MMPs), and increase of the MMPs inhibitor (TIMP-2) expression.	betulinic acid	13-15	matrix metallopeptidase 2	Homo sapiens	149-153	
29423083-6	2018	Furthermore, histological and immunohistochemical analyses showed a decrease in MMP-9 positive cells, MMP-2 positive cells and Ki-67 positive cells and an increase in cleaved caspase-3 positive cells upon BA administration.	betulinic acid	205-207	matrix metallopeptidase 2	Homo sapiens	102-107	
32412117-7	2020	Pathological and immunohistochemical tests showed that Ki-67+ and MMP-2+ cells were dramatically decreased after BA administration, indicating that BA can not only suppress proliferation, but also inhibit migration of tumor cells.	betulinic acid	113-115	matrix metallopeptidase 2	Homo sapiens	66-71	
20872792-8	2010	Additionally, BA suppressed the protein and mRNA expression levels of MMP-2/-9 in a dose-dependent manner.	betulinic acid	14-16	matrix metallopeptidase 2	Homo sapiens	70-78	
20872792-11	2010	Our results showed that BA exerts multiple effects on HG-induced HASMC proliferation and migration, including the inhibition of both MMP-2 and MMP-9 transcription, protein activity, and the downregulation of ROS/NF-kappaB signaling, thereby suggesting that BA may be a possible therapeutic approach to the inhibition of diabetic vascular disease.	betulinic acid	24-26	matrix metallopeptidase 2	Homo sapiens	133-138	
32412117-7	2020	Pathological and immunohistochemical tests showed that Ki-67+ and MMP-2+ cells were dramatically decreased after BA administration, indicating that BA can not only suppress proliferation, but also inhibit migration of tumor cells.	betulinic acid	148-150	matrix metallopeptidase 2	Homo sapiens	66-71	
30417527-8	2019	Furthermore, BA also significantly inhibited HCC growth in vivo and blocked pulmonary metastasis of HCC by regulating the metastasis-related proteins including MMP-2, MMP-9, and TIMP2 without obvious toxicity.	betulinic acid	13-15	matrix metallopeptidase 2	Homo sapiens	160-165	
29923216-8	2018	Furthermore, the migrative and invasive capabilities of renal cancer cells were markedly repressed by BA treatment, which was related to upregulation of matrix metalloproteinase (MMP)2, MMP9, and vimentin, and downregulation of tissue inhibitor of metalloproteinase 2 and E-cadherin.	betulinic acid	102-104	matrix metallopeptidase 2	Homo sapiens	153-184