PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19925787-10	2010	In addition, rottlerin reduced the decay of TNFalpha mRNA, which is an important target of TTP.	rottlerin	13-22	tumor necrosis factor	Homo sapiens	44-52	
25215078-4	2012	Several inhibitors including D609, U73122, PP1, safingol, rottlerin and non-radioactive protein kinase C (PKC) were used to examine the mechanism of signal transduction of TNF-alpha-regulated IP3R1 in HMCs.	rottlerin	58-67	tumor necrosis factor	Homo sapiens	172-181	
21971413-8	2011	Furthermore, rottlerin also enhanced tumor necrosis factor-alpha (TNF-alpha), phorbol myristate acetate (PMA), and lipopolysaccharide (LPS)-induced COX-2 expression.	rottlerin	13-22	tumor necrosis factor	Homo sapiens	37-64	
21971413-8	2011	Furthermore, rottlerin also enhanced tumor necrosis factor-alpha (TNF-alpha), phorbol myristate acetate (PMA), and lipopolysaccharide (LPS)-induced COX-2 expression.	rottlerin	13-22	tumor necrosis factor	Homo sapiens	66-75	
12373288-3	2002	Conversely, rottlerin, an inhibitor of PKCdelta, decreased sensitivity of HeLa cells to cisplatin but it potentiated TNF-induced cell death.	rottlerin	12-21	tumor necrosis factor	Homo sapiens	117-120	
15489375-2	2005	In the present study, we show that pretreatment with rottlerin, a specific inhibitor of protein kinase C (PKC)-delta, or transient transfection with antisense PKCdelta oligonucleotides significantly inhibits TNF-alpha-induced expression of VCAM-1, but not of intercellular adhesion molecule (ICAM)-1 in human lung epithelium A549 cells.	rottlerin	53-62	tumor necrosis factor	Homo sapiens	208-217	
12759450-4	2003	Expression of a dominant negative PKC delta mutant (PKC delta-KR) or pretreatment of cells with rottlerin, a chemical PKC delta inhibitor, attenuated TNF-alpha- and phorbol ester-induced transcription from the IL-8 promoter.	rottlerin	96-105	tumor necrosis factor	Homo sapiens	150-159	
12732207-9	2003	The only inhibitor that was able to block IL-1beta- and TNFalpha-induced nephrin upregulation was rottlerin, which has been suggested to act as a selective PKCdelta inhibitor.	rottlerin	98-107	tumor necrosis factor	Homo sapiens	56-64	
30685603-6	2019	Quercetin, rottlerin, SP600125 and U0126 attenuated TNF-alpha-stimulated c-Jun phosphorylation and AP-1-Luc activity.	rottlerin	11-20	tumor necrosis factor	Homo sapiens	52-61	
12169276-0	2002	Potentiation of tumor necrosis factor-alpha-induced cell death by rottlerin through a cytochrome-C-independent pathway.	rottlerin	66-75	tumor necrosis factor	Homo sapiens	16-43	
12169276-3	2002	The PKC-specific inhibitor bisindolylmaleimide and the PKCdelta inhibitor rottlerin enhanced TNF-induced cell death.	rottlerin	74-83	tumor necrosis factor	Homo sapiens	93-96	
12169276-4	2002	We have investigated if potentiation of TNF-induced cell death by rottlerin involved amplification of the mitochondrial pathway.	rottlerin	66-75	tumor necrosis factor	Homo sapiens	40-43	
12169276-11	2002	These results suggest that rottlerin activates a cytochrome-c-independent cell death pathway to potentiate cell death by TNF.	rottlerin	27-36	tumor necrosis factor	Homo sapiens	121-124	
11274209-5	2001	Specific inhibition of PKCdelta by rottlerin prevented IkappaBalpha degradation and NF-kappaB activation in TNFalpha-stimulated neutrophils.	rottlerin	35-44	tumor necrosis factor	Homo sapiens	108-116	
11274209-6	2001	This regulation of NF-kappaB activation by PKCdelta was specific only for TNFalpha signaling, since lipopolysaccharide- or interleukin-1beta-induced NF-kappaB activation and IkappaBalpha degradation were not inhibited by rottlerin.	rottlerin	221-230	tumor necrosis factor	Homo sapiens	74-82	
11078718-6	2000	Staurosporine and the PKC-delta inhibitor rottlerin inhibited TNF-alpha-triggered serine but not threonine phosphorylation.	rottlerin	42-51	tumor necrosis factor	Homo sapiens	62-71	
30685603-8	2019	TNF-alpha significantly increased MMP-9 promoter activity and THP-1 cell adherence, and these effects were attenuated by pretreatment with quercetin, rottlerin, SP600125, U0126, tanshinone IIA or Bay 11-7082.	rottlerin	150-159	tumor necrosis factor	Homo sapiens	0-9	
12055072-6	2002	TNF-alpha inhibited spontaneous apoptosis in fibronectin-adherent neutrophils, and this antiapoptotic signaling was blocked by the PKC-delta inhibitor rottlerin, but not by an inhibitor of Ca(2+)-dependent PKC isotypes, Go-6976.	rottlerin	151-160	tumor necrosis factor	Homo sapiens	0-9	
30685603-7	2019	Pretreatment with quercetin, rottlerin, SP600125, or Bay 11-7082 attenuated TNF-alpha-induced NF-kappaB (p65) phosphorylation, translocation and RelA/p65-Luc activity.	rottlerin	29-38	tumor necrosis factor	Homo sapiens	76-85	
25675437-7	2015	TNF-alpha-stimulated JNK1/2 was also reduced by Rottlerin or SP600125.	rottlerin	48-57	tumor necrosis factor	Homo sapiens	0-9	
25675437-9	2015	We observed that TNF-alpha induced c-Jun phosphorylation which was inhibited by Rottlerin or SP600125.	rottlerin	80-89	tumor necrosis factor	Homo sapiens	17-26