PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33023784-0 2020 Imiquimod-induced dermatitis impairs thymic tolerance of autoreactive CD4+ T cells to desmoglein 3. Imiquimod 0-9 desmoglein 3 Mus musculus 86-98 33023784-5 2020 OBJECTIVE: We investigated whether imiquimod-induced dermatitis causes ATI and impairs thymic immune tolerance against desmoglein 3 (Dsg3), an epidermal autoantigen of pemphigus vulgaris. Imiquimod 35-44 desmoglein 3 Mus musculus 119-131 33023784-5 2020 OBJECTIVE: We investigated whether imiquimod-induced dermatitis causes ATI and impairs thymic immune tolerance against desmoglein 3 (Dsg3), an epidermal autoantigen of pemphigus vulgaris. Imiquimod 35-44 desmoglein 3 Mus musculus 133-137 33023784-11 2020 Accordingly, the number of Dsg3-experssing UEA-1+keratin 5+mTEC decreased in the thymus during imiquimod-induced dermatitis. Imiquimod 95-104 desmoglein 3 Mus musculus 27-31 33023784-12 2020 Although Dsg3-sepcific transgenic thymocytes was usually deleted in the thymus under physiological condition by central tolerance, Dsg3-sepcific transgenic CD4+CD8- thymocytes significantly increased in number under imiquimod-induced dermatitis. Imiquimod 216-225 desmoglein 3 Mus musculus 131-135