PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32360800-5 2020 Additionally, LZD significantly reduced colonic inflammation in UC mice by inhibiting the production of bone marrow peroxidase (MPO), superoxide dismutase (SOD), nitric oxide (NO) and cytokines (TNF-alpha, IFN-gamma, IL-1beta and IL-6). Linezolid 14-17 interferon gamma Mus musculus 206-215 23478252-10 2013 Compared to placebo, coinfected mice treated with linezolid, vancomycin or clindamycin had decreased pulmonary IL-6 and mKC at 4 hours and IFN-gamma at 24 hours after MRSA coinfection (all P<0.05). Linezolid 50-59 interferon gamma Mus musculus 139-148 23833238-0 2013 Linezolid decreases susceptibility to secondary bacterial pneumonia postinfluenza infection in mice through its effects on IFN-gamma. Linezolid 0-9 interferon gamma Mus musculus 123-132 25635685-6 2015 As compared to animals receiving Vanco, LZD group had significantly lower numbers of neutrophils in the BAL (9x10(3) vs. 2.3x10(4), p < 0.01), which was associated with reduced levels of chemotactic chemokines and inflammatory cytokines KC, MIP-2, IFN-gamma, TNF-alpha and IL-1beta in the BAL. Linezolid 40-43 interferon gamma Mus musculus 251-260 23833238-4 2013 Recent data suggest that the oxazolidinone antibiotic linezolid decreases IFN-gamma and TNF-alpha production in vitro from stimulated PBMCs. Linezolid 54-63 interferon gamma Mus musculus 74-83 23833238-5 2013 We therefore sought to determine whether linezolid would reverse immune hyporesponsiveness after influenza infection in mice through its effects on IFN-gamma. Linezolid 41-50 interferon gamma Mus musculus 148-157 23833238-6 2013 In vivo dose-response studies demonstrated that oral linezolid administration sufficiently decreased bronchoalveolar lavage fluid levels of IFN-gamma at day 7 postinfluenza infection in a dose-dependent manner. Linezolid 53-62 interferon gamma Mus musculus 140-149 23833238-10 2013 This partially reversed the protective effects observed in the linezolid-treated mice, suggesting that the modulatory effects of linezolid are mediated partially by its ability to blunt IFN-gamma production. Linezolid 63-72 interferon gamma Mus musculus 186-195 23833238-10 2013 This partially reversed the protective effects observed in the linezolid-treated mice, suggesting that the modulatory effects of linezolid are mediated partially by its ability to blunt IFN-gamma production. Linezolid 129-138 interferon gamma Mus musculus 186-195