PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	protein kinase C epsilon	Homo sapiens	134-144	
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	77-85	protein kinase C epsilon	Homo sapiens	134-144	
17257588-0	2007	PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.	apicidin	81-89	protein kinase C epsilon	Homo sapiens	0-10	
17257588-2	2007	In this study, we show that protein kinase C (PKC) signaling pathway is required for the induction of gelsolin by the histone deacetylase inhibitor apicidin in HeLa cells.	apicidin	148-156	protein kinase C epsilon	Homo sapiens	46-49	
17257588-5	2007	Furthermore, inhibition of PKCepsilon by either siRNA or dominant-negative mutant completely abrogates the expression of gelsolin by apicidin, indicating that PKCepsilon is the major isoform for this process.	apicidin	133-141	protein kinase C epsilon	Homo sapiens	27-37	
12955081-0	2003	Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.	apicidin	80-88	protein kinase C epsilon	Homo sapiens	110-121	
12955081-1	2003	We previously reported that the activation of p21(WAF1/Cip1) transcription by histone deacetylase inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of protein kinase C (PKC).	apicidin	108-116	protein kinase C epsilon	Homo sapiens	211-214	
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	66-74	protein kinase C epsilon	Homo sapiens	39-50	
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	66-74	protein kinase C epsilon	Homo sapiens	179-190	
12955081-5	2003	Furthermore, membrane translocation of PKC epsilon in response to apicidin was blocked by the PI 3-kinase inhibitor, indicating the role of PI 3-kinase as an upstream molecule of PKC epsilon in the p21(WAF1/Cip1) promoter activation by apicidin.	apicidin	236-244	protein kinase C epsilon	Homo sapiens	39-50	
12955081-6	2003	However, the p21(WAF1/Cip1) expression by apicidin appeared to be independent of the histone hyperacetylation, since apicidin-induced histone hyperacetylation of p21(WAF1/Cip1) promoter region was not affected by inhibition of PI 3-kinase and PKC, suggesting that the chromatin remodeling through the histone hyperacetylation alone might not be sufficient for the expression of p21(WAF1/Cip1) by apicidin.	apicidin	117-125	protein kinase C epsilon	Homo sapiens	243-246	
12955081-7	2003	Taken together, these results suggest that the PI 3-kinase-PKC epsilon signaling pathway plays a pivotal role in the expression of the p21(WAF1/Cip1) by apicidin.	apicidin	153-161	protein kinase C epsilon	Homo sapiens	59-70	
11551946-4	2001	Consistent with the transcriptional activation of p21(WAF1/Cip1) promoter by apicidin, apicidin treatment led to the translocation of PKCepsilon from cytosolic to particulate fraction, which was reversed by pretreatment with calphostin C, indicating the involvement of PKC in the transcriptional activation of p21(WAF1/Cip1) via Sp1 sites by apicidin.	apicidin	87-95	protein kinase C epsilon	Homo sapiens	134-137