PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19267380-1 2009 Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4- or 1,5-disubstituted 1,2,3-triazole in place of a backbone amide bond to fix the bond in question in either a trans-like or a cis-like configuration. apicidin 47-55 histone deacetylase 9 Homo sapiens 92-111 25316709-8 2015 We also found that global hyperacetylation generated by the nonspecific histone deacetylase HDAC inhibitor Apicidin induces monocyte differentiation. apicidin 107-115 histone deacetylase 9 Homo sapiens 92-96 28174211-6 2017 TSA, MGCD0103, and the cyclic peptide class I HDAC inhibitor, apicidin, exhibited a common ability to enhance histone acetylation, and all potently blocked cardiac fibroblast cell cycle progression. apicidin 62-70 histone deacetylase 9 Homo sapiens 46-50 22818786-1 2012 The effect of inhibitors of histone deacetylase (HDAC) on Apicomplexa has been previously reported with the discovery of apicidin, a cyclic tetrapeptide having broad-spectrum antiparasitic activity. apicidin 121-129 histone deacetylase 9 Homo sapiens 49-53 22818786-10 2012 The lower IC(50) values of apicidin against apicomplexan parasites than those of mammalian cells point to HDAC as an excellent drug target. apicidin 27-35 histone deacetylase 9 Homo sapiens 106-110 20181093-10 2010 Similar effects were seen with a structurally dissimilar HDAC inhibitor apicidin. apicidin 72-80 histone deacetylase 9 Homo sapiens 57-61 19267380-1 2009 Fooling enzymes with mock amides: Analogues of apicidin, a cyclic-tetrapeptide inhibitor of histone deacetylase (HDAC), were designed with a 1,4- or 1,5-disubstituted 1,2,3-triazole in place of a backbone amide bond to fix the bond in question in either a trans-like or a cis-like configuration. apicidin 47-55 histone deacetylase 9 Homo sapiens 113-117 19267380-3 2009 One analogue proved in some cases to be superior to apicidin as an HDAC inhibitor. apicidin 52-60 histone deacetylase 9 Homo sapiens 67-71 18275843-0 2008 Histone deacetylase inhibitor apicidin-mediated drug resistance: involvement of P-glycoprotein. apicidin 30-38 histone deacetylase 9 Homo sapiens 0-19 18275843-2 2008 In this study, we show that the histone deacetylase (HDAC) inhibitor apicidin leads to resistance of HeLa cells to paclitaxel through the induction of P-gp expression. apicidin 69-77 histone deacetylase 9 Homo sapiens 32-51 18275843-2 2008 In this study, we show that the histone deacetylase (HDAC) inhibitor apicidin leads to resistance of HeLa cells to paclitaxel through the induction of P-gp expression. apicidin 69-77 histone deacetylase 9 Homo sapiens 53-57 18275843-7 2008 Although HDAC inhibitors are widely appreciated as a new class of anti-tumor agent, our findings clearly demonstrate that apicidin treatment may lead to P-gp-mediated resistance to other anti-tumor agents, suggesting a need for careful design of clinical applications using HDAC inhibitors. apicidin 122-130 histone deacetylase 9 Homo sapiens 274-278 17935135-12 2008 Use of Apicidin (an HDAC inhibitor) and TBB revealed that CK2-dependent HDAC activation contributed to pVHL downregulation and HIF-1alpha stabilization under hypoxia. apicidin 7-15 histone deacetylase 9 Homo sapiens 20-24 17935135-12 2008 Use of Apicidin (an HDAC inhibitor) and TBB revealed that CK2-dependent HDAC activation contributed to pVHL downregulation and HIF-1alpha stabilization under hypoxia. apicidin 7-15 histone deacetylase 9 Homo sapiens 72-76 10893438-0 2000 Apicidin, an inhibitor of histone deacetylase, prevents H-ras-induced invasive phenotype. apicidin 0-8 histone deacetylase 9 Homo sapiens 26-45 16516150-0 2006 Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites. apicidin 30-38 histone deacetylase 9 Homo sapiens 0-19 16516150-1 2006 We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner. apicidin 52-60 histone deacetylase 9 Homo sapiens 15-34 16516150-1 2006 We show that a histone deacetylase (HDAC) inhibitor apicidin increases the transcriptional activity of cyclin E gene, which results in accumulation of cyclin E mRNA and protein in a time- and dose-dependent manner. apicidin 52-60 histone deacetylase 9 Homo sapiens 36-40 16516150-4 2006 Our results demonstrate that regulation of histone modification by an HDAC inhibitor apicidin contributes to induction of cyclin E expression and this effect is Sp1-dependent. apicidin 85-93 histone deacetylase 9 Homo sapiens 70-74 17407153-4 2007 In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of cyclin D3 in response to HDAC inhibitors in human colon cancer cells. apicidin 33-41 histone deacetylase 9 Homo sapiens 18-22 17407153-4 2007 In present study, HDAC inhibitor apicidin was used to elucidate the effect on expression of cell cycle related proteins and the molecular mechanism for transcriptional regulation of cyclin D3 in response to HDAC inhibitors in human colon cancer cells. apicidin 33-41 histone deacetylase 9 Homo sapiens 207-211 17407153-10 2007 Taken together, these results suggest that the activation of cyclin D3 transcription by HDAC inhibitor apicidin was mediated through Sp1 sites and pointed to the possible participation of PKC-delta. apicidin 103-111 histone deacetylase 9 Homo sapiens 88-92 16628233-2 2006 Here, we demonstrate a new mechanism for activation of nuclear factor-kappaB (NF-kappaB) by HDAC inhibitor apicidin and the role of NF-kappaB signaling pathway for mediating differential cellular responses, especially, apoptosis. apicidin 107-115 histone deacetylase 9 Homo sapiens 92-96 16844092-2 2006 To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. apicidin 111-119 histone deacetylase 9 Homo sapiens 28-32 16844092-2 2006 To identify gene targets of HDAC inhibitors, we found that HDAC inhibitors such as sodium butyrate, scriptaid, apicidin and oxamflatin induced the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a potential cyclooxygenase-2 (COX-2) antagonist and tumor suppressor, in a time and concentration dependent manner in A549 and H1435 lung adenocarcinoma cells. apicidin 111-119 histone deacetylase 9 Homo sapiens 59-63 16762634-10 2006 (3) SULF1 enhanced the induction of apoptosis by the HDAC inhibitors apicidin and scriptaid. apicidin 69-77 histone deacetylase 9 Homo sapiens 53-57 12678732-4 2002 In the class of HDAC inhibitors, now included a short-chain fatty acids, such as 4-phenylbutyrate and valporic acid, hydroxamic acids, such as suberoylanilide hydroxamic acid (SAHA), pyroxamide, trichostatin A, oxamflatin and CHAPSs, cyclic tetrapeptides, such as trapoxin, apicidin and depsipeptide-also known as FK-228 or FR 901228, and benzamides, such as MS-275. apicidin 274-282 histone deacetylase 9 Homo sapiens 16-20 10893438-2 2000 In the present study, we have examined the anti-invasive effect of apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl -L-2-amin o-8-oxodecanoyl)], a fungal metabolite that was identified as an antiprotozoal agent known to inhibit parasite histone deacetylase (HDAC). apicidin 67-75 histone deacetylase 9 Homo sapiens 258-277 10893438-2 2000 In the present study, we have examined the anti-invasive effect of apicidin [cyclo(N-O-methyl-L-tryptophanyl-L-isoleucinyl-D-pipecolinyl -L-2-amin o-8-oxodecanoyl)], a fungal metabolite that was identified as an antiprotozoal agent known to inhibit parasite histone deacetylase (HDAC). apicidin 67-75 histone deacetylase 9 Homo sapiens 279-283 10893438-4 2000 We also show that apicidin induces a morphological reversal and growth inhibition of H-ras MCF10A cells similar to that induced by other HDAC inhibitors. apicidin 18-26 histone deacetylase 9 Homo sapiens 137-141 30405794-0 2018 HDAC inhibitor apicidin suppresses murine oral squamous cell carcinoma cell growth in vitro and in vivo via inhibiting HDAC8 expression. apicidin 15-23 histone deacetylase 9 Homo sapiens 0-4 30405794-1 2018 Apicidin, a cyclic peptide histone deacetylase (HDAC) inhibitor, has been demonstrated to exhibit antitumor activity in a number of human cancer types. apicidin 0-8 histone deacetylase 9 Homo sapiens 27-46 30405794-1 2018 Apicidin, a cyclic peptide histone deacetylase (HDAC) inhibitor, has been demonstrated to exhibit antitumor activity in a number of human cancer types. apicidin 0-8 histone deacetylase 9 Homo sapiens 48-52 28951421-3 2017 We found that, in Jurkat T cells and in in vitro-differentiated Th17 cells, treatment with 2 HDAC inhibitors, butyrate and apicidin, led to the induction of the RORgammaT gene, which was associated with an increase in histone H4 acetylation near the RORgammaT proximal promoter. apicidin 123-131 histone deacetylase 9 Homo sapiens 93-97 29749437-5 2018 Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis. apicidin 14-22 histone deacetylase 9 Homo sapiens 26-45 29749437-5 2018 Unexpectedly, apicidin, a histone deacetylase (HDAC) inhibitor, effectively downregulated the expression of IL7R in a dose-dependent manner at an early time-point, as determined by quantitative polymerase chain reaction and IL7R immunostaining, and did not require de novo protein synthesis. apicidin 14-22 histone deacetylase 9 Homo sapiens 47-51