PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28647365-8 2017 Moreover in presence of CLA, peroxisome proliferators-activated receptor gamma(PPARgamma) and CCAAT/enhancer-binding protein (C/EBPalpha) were down-regulated. Linoleic Acids, Conjugated 24-27 peroxisome proliferator activated receptor gamma Mus musculus 29-89 30279515-1 2019 Conjugated linoleic acid (CLA) has been shown to activate the nuclear receptor PPAR-gamma and modulate metabolic and immune functions. Linoleic Acids, Conjugated 26-29 peroxisome proliferator activated receptor gamma Mus musculus 79-89 30279515-4 2019 Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. Linoleic Acids, Conjugated 78-81 peroxisome proliferator activated receptor gamma Mus musculus 24-34 30279515-4 2019 Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. Linoleic Acids, Conjugated 78-81 peroxisome proliferator activated receptor gamma Mus musculus 151-161 30279515-4 2019 Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. Linoleic Acids, Conjugated 133-136 peroxisome proliferator activated receptor gamma Mus musculus 24-34 30279515-4 2019 Conditional deletion of PPAR-gamma in macrophages from mice supplemented with CLA diet resulted in loss of this protective effect of CLA, suggesting a PPAR-gamma-dependent mechanism mediated by macrophages. Linoleic Acids, Conjugated 133-136 peroxisome proliferator activated receptor gamma Mus musculus 151-161 30279515-5 2019 However, CLA supplementation significantly worsened colorectal tumor formation induced by azoxymethane and DSS by inducing macrophage and T-cell-producing TGF-beta via PPAR-gamma activation. Linoleic Acids, Conjugated 9-12 peroxisome proliferator activated receptor gamma Mus musculus 168-178 20223456-3 2010 CLA mediates its effect at least in part via activation of the nuclear receptor, peroxisome proliferator activator receptor-gamma (PPARgamma). Linoleic Acids, Conjugated 0-3 peroxisome proliferator activated receptor gamma Mus musculus 131-140 20508519-6 2010 In mice, CLA prevented inflammation-driven colorectal cancer by activating PPAR gamma and modulating regulatory T cells and macrophages. Linoleic Acids, Conjugated 9-12 peroxisome proliferator activated receptor gamma Mus musculus 75-85 25035711-2 2014 It has previously been reported that conjugated linoleic acid (CLA) inhibits adipogenesis via a peroxisome-proliferator activated receptor-gamma (PPARgamma) mediated mechanism, while it increases osteoblastogenesis via a PPARgamma-independent mechanism in mesenchymal stem cells. Linoleic Acids, Conjugated 63-66 peroxisome proliferator activated receptor gamma Mus musculus 96-144 25035711-2 2014 It has previously been reported that conjugated linoleic acid (CLA) inhibits adipogenesis via a peroxisome-proliferator activated receptor-gamma (PPARgamma) mediated mechanism, while it increases osteoblastogenesis via a PPARgamma-independent mechanism in mesenchymal stem cells. Linoleic Acids, Conjugated 63-66 peroxisome proliferator activated receptor gamma Mus musculus 146-155 25035711-2 2014 It has previously been reported that conjugated linoleic acid (CLA) inhibits adipogenesis via a peroxisome-proliferator activated receptor-gamma (PPARgamma) mediated mechanism, while it increases osteoblastogenesis via a PPARgamma-independent mechanism in mesenchymal stem cells. Linoleic Acids, Conjugated 63-66 peroxisome proliferator activated receptor gamma Mus musculus 221-230 20089779-4 2010 Dietary CLA ameliorated disease activity, decreased colitis, and prevented adenocarcinoma formation in the PPARgamma-expressing floxed mice but not in the tissue-specific PPARgamma-null mice. Linoleic Acids, Conjugated 8-11 peroxisome proliferator activated receptor gamma Mus musculus 107-116 20089779-5 2010 Dietary CLA supplementation significantly decreased the percentages of macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype and increased regulatory T cell numbers in MLN of PPARgamma-expressing, but not in the tissue-specific, PPARgamma-null mice. Linoleic Acids, Conjugated 8-11 peroxisome proliferator activated receptor gamma Mus musculus 196-205 20089779-5 2010 Dietary CLA supplementation significantly decreased the percentages of macrophages in the mesenteric lymph nodes (MLN) regardless of the genotype and increased regulatory T cell numbers in MLN of PPARgamma-expressing, but not in the tissue-specific, PPARgamma-null mice. Linoleic Acids, Conjugated 8-11 peroxisome proliferator activated receptor gamma Mus musculus 250-259 20089779-7 2010 This study suggests CLA ameliorates colitis and prevents tumor formation in part through a PPARgamma-dependent mechanism. Linoleic Acids, Conjugated 20-23 peroxisome proliferator activated receptor gamma Mus musculus 91-100 18993052-10 2009 Coactivator recruitment by CLA isomers showed their distinct properties as selective receptor modulators for PPARgamma and RXRalpha. Linoleic Acids, Conjugated 27-30 peroxisome proliferator activated receptor gamma Mus musculus 109-118 17654485-1 2008 We previously reported that PEGylated conjugated linoleic acid (PCLA) as a pro-drug treatment of cultures of 3T3-L1 cells containing differentiated adipocytes caused de-differentiation by downregulation of PPARgamma2-induced adipogenesis, and cell apoptosis induced by PCLA was lower than that induced by conjugated linoleic acid (CLA) owing to the biocompatible and hydrophilic properties of poly(ethylene glycol) (PEG). Linoleic Acids, Conjugated 65-68 peroxisome proliferator activated receptor gamma Mus musculus 206-216 18769950-2 2008 Since conjugated linoleic acids (CLA) were also demonstrated to activate PPARalpha and PPARgamma in vivo and in vitro, we tested the hypothesis that CLA are also capable of reducing macrophage foam cell cholesterol accumulation. Linoleic Acids, Conjugated 33-36 peroxisome proliferator activated receptor gamma Mus musculus 87-96 18769950-2 2008 Since conjugated linoleic acids (CLA) were also demonstrated to activate PPARalpha and PPARgamma in vivo and in vitro, we tested the hypothesis that CLA are also capable of reducing macrophage foam cell cholesterol accumulation. Linoleic Acids, Conjugated 149-152 peroxisome proliferator activated receptor gamma Mus musculus 87-96 15362034-2 2004 We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism. Linoleic Acids, Conjugated 59-62 peroxisome proliferator activated receptor gamma Mus musculus 93-141 18551182-1 2008 Dietary peroxisome proliferator-activated receptor (PPAR)gamma ligands, linoleic acid (LA) and conjugated linoleic acid (CLA), showed anticancer effects in colorectal carcinoma cells. Linoleic Acids, Conjugated 121-124 peroxisome proliferator activated receptor gamma Mus musculus 52-62 16896890-3 2006 CLA-induced growth inhibition was recovered by the exposure to antisense S-oligodeoxynucleotide for peroxisome proliferator-activated receptor (PPAR)-gamma. Linoleic Acids, Conjugated 0-3 peroxisome proliferator activated receptor gamma Mus musculus 100-155 16896890-9 2006 CLA-treated LL2 tumors showed decrease of PPARgamma and EGFR proteins and increase of BAX protein in comparison with untreated tumors. Linoleic Acids, Conjugated 0-3 peroxisome proliferator activated receptor gamma Mus musculus 42-51 16182300-7 2006 However, PPARalpha and PPARgamma expression was increased in the aorta of the CLA-treated animals. Linoleic Acids, Conjugated 78-81 peroxisome proliferator activated receptor gamma Mus musculus 23-32 15642120-3 2005 The molecular mechanisms responsible for these effects are unclear, and there are conflicting reports on the effects of CLA on peroxisomal proliferator-activated receptor-gamma (PPARgamma) activation and expression. Linoleic Acids, Conjugated 120-123 peroxisome proliferator activated receptor gamma Mus musculus 127-176 15642120-3 2005 The molecular mechanisms responsible for these effects are unclear, and there are conflicting reports on the effects of CLA on peroxisomal proliferator-activated receptor-gamma (PPARgamma) activation and expression. Linoleic Acids, Conjugated 120-123 peroxisome proliferator activated receptor gamma Mus musculus 178-187 15642120-11 2005 CLA enriched with its trans-10, cis-12 isomer, but not with its cis-9, trans-11 isomer, stimulated PPARgamma-mediated reporter gene activity; both isomers stimulated PPARalpha-mediated reporter gene activity. Linoleic Acids, Conjugated 0-3 peroxisome proliferator activated receptor gamma Mus musculus 99-108 16877747-1 2006 Conjugated linoleic acid (CLA), a naturally occurring peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, exhibits proapoptotic, immunomodulatory, and anticancer properties. Linoleic Acids, Conjugated 26-29 peroxisome proliferator activated receptor gamma Mus musculus 54-102 16877747-1 2006 Conjugated linoleic acid (CLA), a naturally occurring peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, exhibits proapoptotic, immunomodulatory, and anticancer properties. Linoleic Acids, Conjugated 26-29 peroxisome proliferator activated receptor gamma Mus musculus 104-114 15362034-11 2004 Loss of the PPAR gamma gene in the colon abrogated the beneficial effects of CLA in DSS colitis. Linoleic Acids, Conjugated 77-80 peroxisome proliferator activated receptor gamma Mus musculus 12-22 15362034-12 2004 CONCLUSIONS: Our studies provide molecular evidence in vivo, suggesting that CLA ameliorates colitis through a PPAR gamma-dependent mechanism. Linoleic Acids, Conjugated 77-80 peroxisome proliferator activated receptor gamma Mus musculus 111-121 15362034-2 2004 We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism. Linoleic Acids, Conjugated 59-62 peroxisome proliferator activated receptor gamma Mus musculus 143-153 15362034-3 2004 METHODS: The expression of PPAR gamma, delta, and their target genes in the colon of mice fed control or CLA-supplemented diets was assayed after a 7-day dextran sodium sulfate (DSS) challenge by quantitative real-time polymerase chain reaction (PCR). Linoleic Acids, Conjugated 105-108 peroxisome proliferator activated receptor gamma Mus musculus 27-37 12020636-5 2002 In reporter assays, various CLA isomers activated PPAR gamma in RAW264.7 mouse macrophage (RAW) cells. Linoleic Acids, Conjugated 28-31 peroxisome proliferator activated receptor gamma Mus musculus 50-60 12670481-6 2003 Similarly, CLA reduced body fat gain and significantly inhibited the expression of PPAR gamma and its downstream target lipoprotein lipase in mouse adipose tissue. Linoleic Acids, Conjugated 11-14 peroxisome proliferator activated receptor gamma Mus musculus 83-93 11795855-12 2001 Treatment with 50 microM trans-10,cis-12 CLA for 6 d decreased PPARgamma2 levels, and supplementation of CLA-treated cultures with LA increased PPARgamma2 levels compared with cultures treated with CLA alone. Linoleic Acids, Conjugated 41-44 peroxisome proliferator activated receptor gamma Mus musculus 63-73 11795855-12 2001 Treatment with 50 microM trans-10,cis-12 CLA for 6 d decreased PPARgamma2 levels, and supplementation of CLA-treated cultures with LA increased PPARgamma2 levels compared with cultures treated with CLA alone. Linoleic Acids, Conjugated 105-108 peroxisome proliferator activated receptor gamma Mus musculus 144-154