PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 28441890-0 2018 Rosuvastatin ameliorates cognitive impairment in rats fed with high-salt and cholesterol diet via inhibiting acetylcholinesterase activity and amyloid beta peptide aggregation. Rosuvastatin Calcium 0-12 acetylcholinesterase Rattus norvegicus 109-129 28441890-2 2018 Therefore, in this article, we examined rosuvastatin (RSV), an oral hypolipidemic drug, to determine its potential as a dual inhibitor of acetylcholinesterase (AChE) and Abeta peptide aggregation for the treatment of cognitive impairment. Rosuvastatin Calcium 40-52 acetylcholinesterase Rattus norvegicus 138-158 28441890-2 2018 Therefore, in this article, we examined rosuvastatin (RSV), an oral hypolipidemic drug, to determine its potential as a dual inhibitor of acetylcholinesterase (AChE) and Abeta peptide aggregation for the treatment of cognitive impairment. Rosuvastatin Calcium 40-52 acetylcholinesterase Rattus norvegicus 160-164 28441890-2 2018 Therefore, in this article, we examined rosuvastatin (RSV), an oral hypolipidemic drug, to determine its potential as a dual inhibitor of acetylcholinesterase (AChE) and Abeta peptide aggregation for the treatment of cognitive impairment. Rosuvastatin Calcium 54-57 acetylcholinesterase Rattus norvegicus 138-158 28441890-2 2018 Therefore, in this article, we examined rosuvastatin (RSV), an oral hypolipidemic drug, to determine its potential as a dual inhibitor of acetylcholinesterase (AChE) and Abeta peptide aggregation for the treatment of cognitive impairment. Rosuvastatin Calcium 54-57 acetylcholinesterase Rattus norvegicus 160-164 28441890-3 2018 Molecular docking study was done to examine the affinity of RSV with Abeta1-42 and AChE in silico. Rosuvastatin Calcium 60-63 acetylcholinesterase Rattus norvegicus 83-87 28441890-7 2018 RSV ameliorated serum cholesterol level, AChE activity, and Abeta1-42 peptide aggregations in HSCD induced cognitive impairment. Rosuvastatin Calcium 0-3 acetylcholinesterase Rattus norvegicus 41-45 28441890-10 2018 Taken together, these data indicate that RSV may act as a dual inhibitor of AChE and Abeta1-42 peptide aggregation, therefore suggesting a therapeutic strategy for cognitive impairment treatment. Rosuvastatin Calcium 41-44 acetylcholinesterase Rattus norvegicus 76-80