PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
11781309-7	2002	Modeling studies suggest that serine palmitoyltransferase is likely to have a single active site that lies at the Lcb1p small middle dotLcb2p interface and that the mutations in Lcb1p reside near the lysine in Lcb2p that is expected to form the Schiff"s base with the pyridoxal 5"-phosphate cofactor.	Pyridoxal Phosphate	268-290	serine C-palmitoyltransferase LCB1	Saccharomyces cerevisiae S288C	178-183	
11781309-8	2002	Furthermore, mutations in this lysine and in a histidine residue that is also predicted to be important for pyridoxal 5"-phosphate binding to Lcb2p also dominantly inactivate SPT similar to the hereditary sensory neuropathy type 1-like mutations in Lcb1p.	Pyridoxal Phosphate	108-130	serine C-palmitoyltransferase LCB1	Saccharomyces cerevisiae S288C	249-254