PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33099927-6 2020 Inhibition of the MAPK pathway by EGFR inhibitors ositinib or MEK 1 and 2 inhibitors selumetinib prevented the up-regulation of CD274 mRNA and PD-L1 proteins and membranes induced by EGF and IFN-gamma. AZD 6244 85-96 interferon gamma Homo sapiens 191-200 30972766-8 2019 Inhibition of the MAPK pathway, using EGFR inhibitors cetuximab and erlotinib or the MEK 1 and 2 inhibitor selumetinib, prevented EGF- and IFNgamma-induced CD274 mRNA and PD-L1 protein and membrane upregulation, but had no effect on IFNgamma-induced MHC-I upregulation. AZD 6244 107-118 interferon gamma Homo sapiens 139-147 24200969-9 2014 We experimentally showed that TNFalpha, EGFR, IFNalpha, and IFNgamma pathway activities were also upregulated in melanoma cell A375 compared with its sub-line DRO, while DRO was much more sensitive to AZD6244 than A375. AZD 6244 201-208 interferon gamma Homo sapiens 60-68