PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27287717-7 2016 In vivo studies revealed that combining amlexanox with MEK inhibitor AZD6244 significantly inhibited the xenograft tumor growth of NSCLC cells harboring activating EGFR mutations, including EGFR(T790M) Overall, our findings define IKBKE as a direct effector target of EGFR and provide a therapeutic rationale to target IKBKE as a strategy to eradicate EGFR-TKI-resistant NSCLC cells. AZD 6244 69-76 inhibitor of nuclear factor kappa B kinase subunit epsilon Homo sapiens 231-236 27287717-7 2016 In vivo studies revealed that combining amlexanox with MEK inhibitor AZD6244 significantly inhibited the xenograft tumor growth of NSCLC cells harboring activating EGFR mutations, including EGFR(T790M) Overall, our findings define IKBKE as a direct effector target of EGFR and provide a therapeutic rationale to target IKBKE as a strategy to eradicate EGFR-TKI-resistant NSCLC cells. AZD 6244 69-76 inhibitor of nuclear factor kappa B kinase subunit epsilon Homo sapiens 319-324