PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19422044-1	2009	We have recently reported that the mitogen-activated protein kinase/ERK kinase (MEK) inhibitor AZD6244 (ARRY-142886) strikingly potentiated the effects of histone deacetylase inhibitor to induce growth arrest and apoptosis of acute myelogeneous leukemia (AML) cells in association with enhanced upregulation of p21(waf1).	AZD 6244	95-102	cyclin dependent kinase inhibitor 1A	Homo sapiens	311-314	
19548087-3	2009	AZD6244 effectively blocked AraC-induced MEK/ERK activation and enhanced its ability to induce growth arrest and apoptosis of NB4 and HL60 cells in parallel with induction of DNA damage as measured by detection of gamma-H2AX by Western Blot analysis, resulting in enhanced expression of p21( waf1 ) and downregulation of c-Myc and Bcl-xl in these cells.	AZD 6244	0-7	cyclin dependent kinase inhibitor 1A	Homo sapiens	287-290	
19548087-3	2009	AZD6244 effectively blocked AraC-induced MEK/ERK activation and enhanced its ability to induce growth arrest and apoptosis of NB4 and HL60 cells in parallel with induction of DNA damage as measured by detection of gamma-H2AX by Western Blot analysis, resulting in enhanced expression of p21( waf1 ) and downregulation of c-Myc and Bcl-xl in these cells.	AZD 6244	0-7	cyclin dependent kinase inhibitor 1A	Homo sapiens	292-296	
19422044-1	2009	We have recently reported that the mitogen-activated protein kinase/ERK kinase (MEK) inhibitor AZD6244 (ARRY-142886) strikingly potentiated the effects of histone deacetylase inhibitor to induce growth arrest and apoptosis of acute myelogeneous leukemia (AML) cells in association with enhanced upregulation of p21(waf1).	AZD 6244	95-102	cyclin dependent kinase inhibitor 1A	Homo sapiens	315-319	
19422044-4	2009	In parallel, 5-AzadC induced expression of p21(waf1) in AML cells, which was potently enhanced in the presence of AZD6244.	AZD 6244	114-121	cyclin dependent kinase inhibitor 1A	Homo sapiens	43-46	
19422044-4	2009	In parallel, 5-AzadC induced expression of p21(waf1) in AML cells, which was potently enhanced in the presence of AZD6244.	AZD 6244	114-121	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-51	
33416182-6	2021	In addition, Selumetinib induced cell cycle arrest at the G0/G1 phase by downregulating the expression levels of cyclin D1 and p21 and upregulating those of p27 compared with those in the control cells.	AZD 6244	13-24	cyclin dependent kinase inhibitor 1A	Homo sapiens	127-130