PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24375836-0	2014	MiR-92a mediates AZD6244 induced apoptosis and G1-phase arrest of lymphoma cells by targeting Bim.	AZD 6244	17-24	BCL2 like 11	Homo sapiens	94-97	
24375836-8	2014	Silencing Bim decreases AZD6244-induced apoptosis and G1-phase arrest, suggesting that Bim contributes to the growth arrest.	AZD 6244	24-31	BCL2 like 11	Homo sapiens	10-13	
24375836-8	2014	Silencing Bim decreases AZD6244-induced apoptosis and G1-phase arrest, suggesting that Bim contributes to the growth arrest.	AZD 6244	24-31	BCL2 like 11	Homo sapiens	87-90	
24375836-9	2014	Thus, miR-92a mediates AZD6244-induced cytotoxicity of lymphoma cells by targeting Bim.	AZD 6244	23-30	BCL2 like 11	Homo sapiens	83-86	
23234544-0	2013	The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance.	AZD 6244	61-72	BCL2 like 11	Homo sapiens	92-95	
23234544-0	2013	The BH3 mimetic ABT-263 synergizes with the MEK1/2 inhibitor selumetinib/AZD6244 to promote BIM-dependent tumour cell death and inhibit acquired resistance.	AZD 6244	73-80	BCL2 like 11	Homo sapiens	92-95	
20885957-4	2010	We found that AZD6244 elicited a large increase of Bim proteins and a smaller increase of PUMA and NOXA proteins, and induced cell death in sensitive lung cancer cell lines, but had no effect on other Bcl-2 related proteins in those cell lines.	AZD 6244	14-21	BCL2 like 11	Homo sapiens	51-54	
20885957-5	2010	Knockdown of Bim by siRNA greatly increased the IC(50) and reduced apoptosis for AZD6244 treated cells.	AZD 6244	81-88	BCL2 like 11	Homo sapiens	13-16	
20885957-7	2010	In the sensitive cells, AZD6244 induced FOXO3a nuclear translocation required for Bim activation.	AZD 6244	24-31	BCL2 like 11	Homo sapiens	82-85	
20885957-9	2010	In addition, we found that transfection of constitutively active AKT up-regulated p-Thr32-FOXO3a and p-Ser253-FOXO3a expression and inhibited AZD6244-induced Bim expression in sensitive cells.	AZD 6244	142-149	BCL2 like 11	Homo sapiens	158-161	
20885957-10	2010	These results show that Bim plays an important role in AZD6244-induced apoptosis in lung cancer cells and that the PI3K/AKT/FOXO3a pathway is involved in Bim regulation and susceptibility of lung cancer cells to AZD6244.	AZD 6244	55-62	BCL2 like 11	Homo sapiens	24-27	
20885957-10	2010	These results show that Bim plays an important role in AZD6244-induced apoptosis in lung cancer cells and that the PI3K/AKT/FOXO3a pathway is involved in Bim regulation and susceptibility of lung cancer cells to AZD6244.	AZD 6244	212-219	BCL2 like 11	Homo sapiens	154-157