PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22336587-9	2012	In conclusion knockdown MTDH can enhance the breast cancer cells sensitivity to AZD6244 via regulating the expression and activity of FOXO3a.	AZD 6244	80-87	forkhead box O3	Homo sapiens	134-140	
20885957-10	2010	These results show that Bim plays an important role in AZD6244-induced apoptosis in lung cancer cells and that the PI3K/AKT/FOXO3a pathway is involved in Bim regulation and susceptibility of lung cancer cells to AZD6244.	AZD 6244	55-62	forkhead box O3	Homo sapiens	124-130	
20885957-6	2010	We also found that levels of endogenous p-Thr32-FOXO3a and p-Ser253-FOXO3a were lower in AZD6244-sensitive cells than in AZD6244-resistant cells.	AZD 6244	89-96	forkhead box O3	Homo sapiens	48-54	
20885957-6	2010	We also found that levels of endogenous p-Thr32-FOXO3a and p-Ser253-FOXO3a were lower in AZD6244-sensitive cells than in AZD6244-resistant cells.	AZD 6244	89-96	forkhead box O3	Homo sapiens	68-74	
20885957-6	2010	We also found that levels of endogenous p-Thr32-FOXO3a and p-Ser253-FOXO3a were lower in AZD6244-sensitive cells than in AZD6244-resistant cells.	AZD 6244	121-128	forkhead box O3	Homo sapiens	48-54	
20885957-6	2010	We also found that levels of endogenous p-Thr32-FOXO3a and p-Ser253-FOXO3a were lower in AZD6244-sensitive cells than in AZD6244-resistant cells.	AZD 6244	121-128	forkhead box O3	Homo sapiens	68-74	
20885957-7	2010	In the sensitive cells, AZD6244 induced FOXO3a nuclear translocation required for Bim activation.	AZD 6244	24-31	forkhead box O3	Homo sapiens	40-46	
20885957-8	2010	Moreover, the silencing of FOXO3a by siRNA abrogated AZD6244-induced cell apoptosis.	AZD 6244	53-60	forkhead box O3	Homo sapiens	27-33	
20885957-10	2010	These results show that Bim plays an important role in AZD6244-induced apoptosis in lung cancer cells and that the PI3K/AKT/FOXO3a pathway is involved in Bim regulation and susceptibility of lung cancer cells to AZD6244.	AZD 6244	212-219	forkhead box O3	Homo sapiens	124-130	
20484037-4	2010	In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244.	AZD 6244	223-230	forkhead box O3	Homo sapiens	84-90	
20484037-4	2010	In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244.	AZD 6244	223-230	forkhead box O3	Homo sapiens	100-106	
20484037-4	2010	In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244.	AZD 6244	223-230	forkhead box O3	Homo sapiens	100-106	
20484037-6	2010	Our findings define FOXO3a as candidate marker to predict the clinical efficacy of AZD6244.	AZD 6244	83-90	forkhead box O3	Homo sapiens	20-26	
20484037-3	2010	AZD6244 enhanced the expression of transcription factor FOXO3a, which suppressed cancer cell proliferation.	AZD 6244	0-7	forkhead box O3	Homo sapiens	56-62	
20484037-4	2010	In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244.	AZD 6244	3-10	forkhead box O3	Homo sapiens	84-90	
20484037-4	2010	In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244.	AZD 6244	3-10	forkhead box O3	Homo sapiens	100-106	
20484037-4	2010	In AZD6244-resistant cancer cells, we observed the impaired nuclear localization of FOXO3a, reduced FOXO3a-mediated transcriptional activity, and decreased the expression of FOXO3a target gene Bim after cell treatment with AZD6244.	AZD 6244	3-10	forkhead box O3	Homo sapiens	100-106