PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30706361-5	2019	HCT116 cell resistance to MEK inhibitor AZD6244, which inhibited the activation of ERK and promoted the activation of JAK2-STAT3 signaling.	AZD 6244	40-47	signal transducer and activator of transcription 3	Homo sapiens	123-128	
30706361-9	2019	JAK2/STAT3 inhibitor AG490 synergistically increases effects of AZD6244 on colon cancer in vitro and in vivo.	AZD 6244	64-71	signal transducer and activator of transcription 3	Homo sapiens	5-10	
30706361-6	2019	The combination treatment of AZD6244 and AG490 significantly inhibited cell viability and induced cell apoptosis, and completely inhibited the activation of ERK and JAK2-STAT3 signaling.	AZD 6244	29-36	signal transducer and activator of transcription 3	Homo sapiens	170-175	
30706361-8	2019	The treatment of AZD6244 on K-Ras mutations HCT116 cells promoted the activation of JAK2/STAT3 signaling.	AZD 6244	17-24	signal transducer and activator of transcription 3	Homo sapiens	89-94	
21444672-5	2011	Inhibition of this pathway by JSI-124, a STAT3-specific small molecule inhibitor, or with STAT3-specific siRNA sensitized lung cancer cells to AZD6244 and induced apoptosis.	AZD 6244	143-150	signal transducer and activator of transcription 3	Homo sapiens	90-95	
21444672-7	2011	We found that the STAT3-regulated microRNA miR-17 played a critical role in MEK inhibitor resistance, such that miR-17 inhibition sensitized resistant cells to AZD6244 by inducing BIM and PARP cleavage.	AZD 6244	160-167	signal transducer and activator of transcription 3	Homo sapiens	18-23	
21444672-8	2011	Together, these results indicated that STAT3-mediated overexpression of miR-17 blocked BIM expression and caused resistance to AZD6244.	AZD 6244	127-134	signal transducer and activator of transcription 3	Homo sapiens	39-44	
26373715-2	2016	Knockdown expression of GP130 or STAT3 sensitized cells to anti-cancer drugs doxorubicin, cisplatin, and MEK inhibitor AZD6244.	AZD 6244	119-126	signal transducer and activator of transcription 3	Homo sapiens	33-38	
25961376-3	2015	Here, we identified that Signal Transducer and Activator of Transcription 3 (STAT3) was significantly activated following the MEK inhibition using AZD6244, PD98059 and Trametinib in K-Ras mutant pancreatic and colon cancer cells.	AZD 6244	147-154	signal transducer and activator of transcription 3	Homo sapiens	25-75	
25961376-3	2015	Here, we identified that Signal Transducer and Activator of Transcription 3 (STAT3) was significantly activated following the MEK inhibition using AZD6244, PD98059 and Trametinib in K-Ras mutant pancreatic and colon cancer cells.	AZD 6244	147-154	signal transducer and activator of transcription 3	Homo sapiens	77-82	
21690569-13	2011	Enhancement of 5-FU cytotoxicity and 5-FU mediated radiosensitization with selumetinib treatment was accompanied by an increase in mitotic catastrophe and apoptosis, and reductions in Stat3 phosphorylation and survivin expression.	AZD 6244	75-86	signal transducer and activator of transcription 3	Homo sapiens	184-189