PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30706361-5 2019 HCT116 cell resistance to MEK inhibitor AZD6244, which inhibited the activation of ERK and promoted the activation of JAK2-STAT3 signaling. AZD 6244 40-47 signal transducer and activator of transcription 3 Homo sapiens 123-128 30706361-9 2019 JAK2/STAT3 inhibitor AG490 synergistically increases effects of AZD6244 on colon cancer in vitro and in vivo. AZD 6244 64-71 signal transducer and activator of transcription 3 Homo sapiens 5-10 30706361-6 2019 The combination treatment of AZD6244 and AG490 significantly inhibited cell viability and induced cell apoptosis, and completely inhibited the activation of ERK and JAK2-STAT3 signaling. AZD 6244 29-36 signal transducer and activator of transcription 3 Homo sapiens 170-175 30706361-8 2019 The treatment of AZD6244 on K-Ras mutations HCT116 cells promoted the activation of JAK2/STAT3 signaling. AZD 6244 17-24 signal transducer and activator of transcription 3 Homo sapiens 89-94 21444672-5 2011 Inhibition of this pathway by JSI-124, a STAT3-specific small molecule inhibitor, or with STAT3-specific siRNA sensitized lung cancer cells to AZD6244 and induced apoptosis. AZD 6244 143-150 signal transducer and activator of transcription 3 Homo sapiens 90-95 21444672-7 2011 We found that the STAT3-regulated microRNA miR-17 played a critical role in MEK inhibitor resistance, such that miR-17 inhibition sensitized resistant cells to AZD6244 by inducing BIM and PARP cleavage. AZD 6244 160-167 signal transducer and activator of transcription 3 Homo sapiens 18-23 21444672-8 2011 Together, these results indicated that STAT3-mediated overexpression of miR-17 blocked BIM expression and caused resistance to AZD6244. AZD 6244 127-134 signal transducer and activator of transcription 3 Homo sapiens 39-44 26373715-2 2016 Knockdown expression of GP130 or STAT3 sensitized cells to anti-cancer drugs doxorubicin, cisplatin, and MEK inhibitor AZD6244. AZD 6244 119-126 signal transducer and activator of transcription 3 Homo sapiens 33-38 25961376-3 2015 Here, we identified that Signal Transducer and Activator of Transcription 3 (STAT3) was significantly activated following the MEK inhibition using AZD6244, PD98059 and Trametinib in K-Ras mutant pancreatic and colon cancer cells. AZD 6244 147-154 signal transducer and activator of transcription 3 Homo sapiens 25-75 25961376-3 2015 Here, we identified that Signal Transducer and Activator of Transcription 3 (STAT3) was significantly activated following the MEK inhibition using AZD6244, PD98059 and Trametinib in K-Ras mutant pancreatic and colon cancer cells. AZD 6244 147-154 signal transducer and activator of transcription 3 Homo sapiens 77-82 21690569-13 2011 Enhancement of 5-FU cytotoxicity and 5-FU mediated radiosensitization with selumetinib treatment was accompanied by an increase in mitotic catastrophe and apoptosis, and reductions in Stat3 phosphorylation and survivin expression. AZD 6244 75-86 signal transducer and activator of transcription 3 Homo sapiens 184-189