PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17983653-6	2008	AZD6244 potently down-regulated the levels of phospho-ERK1/2 and its downstream effector, p-p70S6K, in the MV4-11 and MOLM13 cells as measured by Western blot analysis.	AZD 6244	0-7	ribosomal protein S6 kinase B1	Homo sapiens	92-98	
25379021-7	2014	Surprisingly, Selumetinib was able to inhibit phosphorylation of p70 S6 kinase (p70S6K) and its downstream target ribosomal protein S6 (RPS6) in sensitive cell lines.	AZD 6244	14-25	ribosomal protein S6 kinase B1	Homo sapiens	65-78	
25379021-7	2014	Surprisingly, Selumetinib was able to inhibit phosphorylation of p70 S6 kinase (p70S6K) and its downstream target ribosomal protein S6 (RPS6) in sensitive cell lines.	AZD 6244	14-25	ribosomal protein S6 kinase B1	Homo sapiens	80-86	
25379021-11	2014	Pharmacological inhibition of p70S6K using the PI3K/mTOR inhibitor NVP-BEZ235, the specific mTOR inhibitor Rapamycin and the specific p70S6K inhibitor PF-4708671 potentiated Selumetinib effects in resistant cells.	AZD 6244	174-185	ribosomal protein S6 kinase B1	Homo sapiens	30-36	
25379021-12	2014	In addition, biological inhibition of p70S6K using siRNA rendered responsiveness to Selumetinib in resistant cell lines.	AZD 6244	84-95	ribosomal protein S6 kinase B1	Homo sapiens	38-44	
25379021-14	2014	We can conclude that p70S6K and its downstream target RPS6 are potential biomarkers of resistance to Selumetinib in colorectal cancer.	AZD 6244	101-112	ribosomal protein S6 kinase B1	Homo sapiens	21-27	
22641227-10	2012	Sorafenib/AZD6244 potently inhibited angiogenesis and phosphorylation             of VEGFR-2, PDGFR-beta and ERK, p90RSK, p70S6K, cdk-2 and retinoblastoma.	AZD 6244	10-17	ribosomal protein S6 kinase B1	Homo sapiens	122-128	
25379021-0	2014	Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.	AZD 6244	14-25	ribosomal protein S6 kinase B1	Homo sapiens	83-89	
25379021-0	2014	Resistance to Selumetinib (AZD6244) in colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.	AZD 6244	27-34	ribosomal protein S6 kinase B1	Homo sapiens	83-89	
17983653-7	2008	Interestingly, when AZD6244 was combined with sunitinib, a FLT3 kinase inhibitor, growth inhibition and apoptosis of both MV4-11 and MOLM13 cells were synergistically enhanced in association with further down-regulation of phospho-ERK1/2 and p-p70S6K in these cells.	AZD 6244	20-27	ribosomal protein S6 kinase B1	Homo sapiens	244-250