PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
19637312-7	2009	In cell lines with coincident ERK1/2 and PKB activation, sensitivity to AZD6244 could be re-imposed by any of the 3 distinct PI3K/mTOR inhibitors.	AZD 6244	72-79	mechanistic target of rapamycin kinase	Homo sapiens	130-134	
26250606-14	2015	CONCLUSIONS: The combination of GSK2126458 and AZD6244 blocks both the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways simultaneously and is an effective strategy for the treatment of CRPCs.	AZD 6244	47-54	mechanistic target of rapamycin kinase	Homo sapiens	100-104	
26498922-8	2015	Our Western blot data indicated that AZD6244 and NVP-BEZ235 perturbed the MAPK and PI3K/mTOR signaling cascades, respectively.	AZD 6244	37-44	mechanistic target of rapamycin kinase	Homo sapiens	88-92	
20101735-5	2010	RESULTS: We report here that pharmacological inhibition of the MEK/ERK pathway by AZD6244 enhanced the antitumor and antiangiogenic activities of mTOR inhibitor RAPA in both orthotopic and ectopic models of HCC.	AZD 6244	82-89	mechanistic target of rapamycin kinase	Homo sapiens	146-150