PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21472898-6 2011 A significant reduction of the elevated levels of serum tumor necrosis factor-alpha (TNF-alpha) as well as serum and cardiac nitrite/nitrate (NOx) ) was achieved after CAPE pretreatment. caffeic acid phenethyl ester 168-172 tumor necrosis factor Rattus norvegicus 56-83 22060287-7 2011 Elevated TNF-alpha and IL-1beta levels were also reduced with CAPE treatment. caffeic acid phenethyl ester 62-66 tumor necrosis factor Rattus norvegicus 9-18 21472898-6 2011 A significant reduction of the elevated levels of serum tumor necrosis factor-alpha (TNF-alpha) as well as serum and cardiac nitrite/nitrate (NOx) ) was achieved after CAPE pretreatment. caffeic acid phenethyl ester 168-172 tumor necrosis factor Rattus norvegicus 85-94 18265948-9 2008 CAPE treatments significantly suppressed these inflammatory cytokines (about 70% for TNF-alpha, 26% for IFN-gamma) and NOS (completely). caffeic acid phenethyl ester 0-4 tumor necrosis factor Rattus norvegicus 85-94 19394397-10 2009 Consistently, CAPE normalized the activity of GR, GPx, SOD and CAT, inhibited the rise in TNF-alpha and ameliorated the histopathological changes. caffeic acid phenethyl ester 14-18 tumor necrosis factor Rattus norvegicus 90-99 12877982-5 2003 Cerebral inflammatory responses were strongly inhibited by CAPE (100 microM): reductions of NFkappaB nuclear activity, tumor necrosis factor alpha and nitric oxide productions were observed. caffeic acid phenethyl ester 59-63 tumor necrosis factor Rattus norvegicus 119-146 15695019-7 2005 In addition, 10 micromol/l caffeic acid phenylethyl ester, a NF-(kappa)B inhibitor, blocked OTA mediated TNF-alpha release. caffeic acid phenethyl ester 27-57 tumor necrosis factor Rattus norvegicus 105-114 16983503-4 2006 The levels of tumor necrosis factor-alpha, interleukin-6, and interleukin-1alpha in the caffeic acid phenethyl ester group were significantly lower than those in the bile duct ligation group (P < 0.03, P < 0.01, and P < 0.02 respectively). caffeic acid phenethyl ester 88-116 tumor necrosis factor Rattus norvegicus 14-41 28479719-10 2017 Furthermore, both the doses of CAPE when administered to rats that were previously treated with STZ-ICV prevented the rise of brain thiobarbituric acid reactive substance as well as TNF-alpha and simultaneously enhanced the GSH content. caffeic acid phenethyl ester 31-35 tumor necrosis factor Rattus norvegicus 182-191 11714876-10 2001 CAPE (30 microg/ml) significantly inhibited NF-kappaB and TNF-alpha production in the macrophage cell line. caffeic acid phenethyl ester 0-4 tumor necrosis factor Rattus norvegicus 58-67 11714876-15 2001 Moreover, colonic cytokine levels (TNF-alpha and IL-1beta) were significantly reduced in CAPE-treated rats. caffeic acid phenethyl ester 89-93 tumor necrosis factor Rattus norvegicus 35-44 34754212-7 2021 Results: Growing rats subjected to the moderate swimming test and in those treated with CAPE showed a lower level of TNF-alpha compared to the negative control. caffeic acid phenethyl ester 88-92 tumor necrosis factor Rattus norvegicus 117-126 31059064-5 2019 In addition, CAPE decreased the severity of inflammation in the retina, reflected by the decreased expression of inflammatory cytokines, including interleukin (IL)-8, IL-6, inducible nitric oxide synthase, cycloooxygenase-2, tumor necrosis factor-alpha and chemokine C-C ligand-2, in CAPE-treated rats. caffeic acid phenethyl ester 13-17 tumor necrosis factor Rattus norvegicus 206-252 30929510-15 2019 Administration of CAPE significantly inhibited apoptosis and cardiac TNF-alpha expression. caffeic acid phenethyl ester 18-22 tumor necrosis factor Rattus norvegicus 69-78 29486334-8 2018 Administration of CAPE lowered oxidative stress, AChE, nitrite and TNF-alpha levels in brain of rats. caffeic acid phenethyl ester 18-22 tumor necrosis factor Rattus norvegicus 67-76 28479719-14 2017 A decline in transfer latency of CAPE treated rats was observed in Elevated Plus Maze model.Profound rise in brain GSH levels and diminution of TBARS as well as TNF-alpha content was observed in brains of CAPE treated rats. caffeic acid phenethyl ester 33-37 tumor necrosis factor Rattus norvegicus 161-170 26122083-5 2015 We found that pretreatment with CAPE effectively attenuated intestinal pathology changes, apoptosis, oxidative stress, bacterial translocation, the content of nitric oxide and myeloperoxidase as well as the concentration of plasma tumor necrosis factor-alpha. caffeic acid phenethyl ester 32-36 tumor necrosis factor Rattus norvegicus 231-258 25948886-1 2015 BACKGROUND AND AIM: The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. caffeic acid phenethyl ester 74-102 tumor necrosis factor Rattus norvegicus 155-190 25904269-1 2015 BACKGROUND: The purpose of this study was to investigate the effects of Caffeic Acid Phenethyl Ester (CAPE) on proinflammatory cytokines, IL-1ss and TNF-alpha, and explore its healing effect after acute spinal cord injury. caffeic acid phenethyl ester 72-100 tumor necrosis factor Rattus norvegicus 149-158 25904269-10 2015 RESULTS: CAPE suppressed TNF-alpha and IL-1ss levels in the serum. caffeic acid phenethyl ester 9-13 tumor necrosis factor Rattus norvegicus 25-34 25904269-12 2015 CONCLUSION: CAPE suppresses the levels of proinflammatory cytokines, TNF-alpha and IL-1ss, after acute spinal cord injury in the early phase and contributes to the healing process. caffeic acid phenethyl ester 12-16 tumor necrosis factor Rattus norvegicus 69-78 26044239-7 2015 RESULTS: In CAPE treated group, decreased serum levels of proinflammatory cytokines (TNF-alpha, IL-6, IL-1beta) and CRP (p < 0.05), additionally increased serum levels of antioxidant parameters (PONS, TAS) (p < 0.05), were observed after IO. caffeic acid phenethyl ester 12-16 tumor necrosis factor Rattus norvegicus 85-94 25948886-1 2015 BACKGROUND AND AIM: The aim of this study was to determine the actions of caffeic acid phenethyl ester (CAPE) on the changes of endothelin-1 (ET-1) level, tumor necrosis factor- (TNF-) alpha, and oxidative stress parameters such as superoxide dismutase (SOD) activities and malondialdehyde (MDA) levels in experimental sepsis model in rats. caffeic acid phenethyl ester 104-108 tumor necrosis factor Rattus norvegicus 155-190 25948886-5 2015 RESULTS: Pretreatment with CAPE decreased ET-1, TNF-alpha, and MDA levels in sepsis induced rats. caffeic acid phenethyl ester 27-31 tumor necrosis factor Rattus norvegicus 48-57 25948886-7 2015 CONCLUSION: Our results demonstrate that CAPE may have a beneficial effect on ET and TNF-alpha levels and oxidative stress parameters induced by sepsis in experimental rat models. caffeic acid phenethyl ester 41-45 tumor necrosis factor Rattus norvegicus 85-94 24508943-13 2014 CAPE inhibited TNF-alpha serum level elevation, induced aortic HO-1 expression and reduced collagen deposition. caffeic acid phenethyl ester 0-4 tumor necrosis factor Rattus norvegicus 15-24 23997916-4 2013 In the present study, the main objective was to investigate the effects of CAPE on some key mediators including TGF-beta1, TNF-alpha and prostaglandin E2 (PGE2) involved in profibrotic/antifibrotic balance and pathogenesis of idiopathic pulmonary fibrosis (IPF). caffeic acid phenethyl ester 75-79 tumor necrosis factor Rattus norvegicus 123-132