PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 14637186-0 2003 Involvement of tumor suppressor protein p53 and p38 MAPK in caffeic acid phenethyl ester-induced apoptosis of C6 glioma cells. caffeic acid phenethyl ester 60-88 tumor protein p53 Homo sapiens 40-43 14625298-4 2004 CAPE activated Fas by a Fas ligand (Fas-L)-independent mechanism, induced p53-regulated Bax protein, and activated caspases. caffeic acid phenethyl ester 0-4 tumor protein p53 Homo sapiens 74-77 14625298-6 2004 SB203580, a specific inhibitor of p38 MAPK, partially suppressed CAPE-induced p53 activation, Bax expression, and apoptosis, consistent with a mechanism by which CAPE leads to Bax activation, known to be regulated by p38 and p53. caffeic acid phenethyl ester 65-69 tumor protein p53 Homo sapiens 78-81 14625298-6 2004 SB203580, a specific inhibitor of p38 MAPK, partially suppressed CAPE-induced p53 activation, Bax expression, and apoptosis, consistent with a mechanism by which CAPE leads to Bax activation, known to be regulated by p38 and p53. caffeic acid phenethyl ester 65-69 tumor protein p53 Homo sapiens 225-228 14625298-6 2004 SB203580, a specific inhibitor of p38 MAPK, partially suppressed CAPE-induced p53 activation, Bax expression, and apoptosis, consistent with a mechanism by which CAPE leads to Bax activation, known to be regulated by p38 and p53. caffeic acid phenethyl ester 162-166 tumor protein p53 Homo sapiens 225-228 14637186-12 2003 The resultant data suggest that p38 MAPK mediated the CAPE-induced p53-dependent apoptosis in C6 glioma cells. caffeic acid phenethyl ester 54-58 tumor protein p53 Homo sapiens 67-70 14637186-7 2003 CAPE application also enhanced the expression of p53, Bax, and Bak. caffeic acid phenethyl ester 0-4 tumor protein p53 Homo sapiens 49-52 14637186-10 2003 More importantly, p38 kinase formed a complex with p53 after the treatment of CAPE for 0.5 hr. caffeic acid phenethyl ester 78-82 tumor protein p53 Homo sapiens 51-54 14981925-7 2003 Apoptosis induced by CAPE or CAO is associated with increased expression of p53, p21 and c-Jun. caffeic acid phenethyl ester 21-25 tumor protein p53 Homo sapiens 76-79 27698914-3 2016 cDNA array performed on the control and CAPE-treated breast cancer cells revealed activation of DNA damage signaling involving upregulation of GADD45alpha and p53 tumor suppressor proteins. caffeic acid phenethyl ester 40-44 tumor protein p53 Homo sapiens 159-162 11429785-5 2001 Although CAPE treatment of two p53 mutant tumor cell lines, NCI-H358 and SK-OV-3, and p53-deficient (p53(-/-)) cells caused the cleavage of caspase-3 as well as DNA fragmentation, caspase-3 cleavage was seen early (at 6 h) only in cells expressing wild-type p53 (p53(+/+)) and Cl 41 cells. caffeic acid phenethyl ester 9-13 tumor protein p53 Homo sapiens 31-34 34995485-5 2022 When CAPE was combined with cisplatin in nine cell lines representative of various histotypes a synergistic effect was observed in TOV112D cells and in the cisplatin-resistant IGROV-1/Pt1 variant, both of endometrioid type and carrying mutant TP53. caffeic acid phenethyl ester 5-9 tumor protein p53 Homo sapiens 243-247 35053438-0 2022 The Antitumor Effect of Caffeic Acid Phenethyl Ester by Downregulating Mucosa-Associated Lymphoid Tissue 1 via AR/p53/NF-kappaB Signaling in Prostate Carcinoma Cells. caffeic acid phenethyl ester 24-52 tumor protein p53 Homo sapiens 114-117 35053438-4 2022 In p53- and androgen receptor (AR)-positive prostate carcinoma cells, CAPE downregulated AR and MALT1 expression but enhanced that of p53, thus decreasing androgen-induced activation of MALT1 and prostate-specific antigen expressions. caffeic acid phenethyl ester 70-74 tumor protein p53 Homo sapiens 3-6 35053438-4 2022 In p53- and androgen receptor (AR)-positive prostate carcinoma cells, CAPE downregulated AR and MALT1 expression but enhanced that of p53, thus decreasing androgen-induced activation of MALT1 and prostate-specific antigen expressions. caffeic acid phenethyl ester 70-74 tumor protein p53 Homo sapiens 134-137 35053438-6 2022 CAPE downregulated MALT1 expression and thus inhibited NF-kappaB activity in p53- and AR-negative prostate carcinoma PC-3 cells, eventually reducing cell proliferation, invasion, and tumor growth in vitro and in vivo. caffeic acid phenethyl ester 0-4 tumor protein p53 Homo sapiens 77-80 35053438-8 2022 Our findings verify that CAPE is an effective antitumor agent for human androgen-dependent and -independent prostate carcinoma cells in vitro and in vivo through the inhibition of MALT1 expression via the AR/p53/NF-kappaB signaling pathways. caffeic acid phenethyl ester 25-29 tumor protein p53 Homo sapiens 208-211 33110364-9 2020 Furthermore, CAPE treatment increased the Serine 15 (Ser15) and Serine 46 (Ser46) phosphorylation of p53, while decreased the survivin expression. caffeic acid phenethyl ester 13-17 tumor protein p53 Homo sapiens 101-104 33110364-10 2020 The results suggested that CAPE induced apoptosis by regulating p53 phosphorylation, leading to inhibition of the survivin expression. caffeic acid phenethyl ester 27-31 tumor protein p53 Homo sapiens 64-67 28790461-9 2017 In conclusion, para-nitro may enhance the anticancer effect of CAPE by inhibiting colon cancer cell viability, inducing apoptosis and cell cycle arrest via the P53 pathway and inhibiting tumour growth and reducing tumour invasion by decreasing the expression of VEGF; additionally, metabolites of CAPE-pNO2 showed differences in cells and organs. caffeic acid phenethyl ester 63-67 tumor protein p53 Homo sapiens 160-163 27698914-4 2016 Molecular docking analysis revealed that CAPE is capable of disrupting mortalin-p53 complexes. caffeic acid phenethyl ester 41-45 tumor protein p53 Homo sapiens 80-83 27698914-5 2016 We provide experimental evidence and demonstrate that CAPE induced disruption of mortalin-p53 complexes led to nuclear translocation and activation of p53 resulting in growth arrest in cancer cells. caffeic acid phenethyl ester 54-58 tumor protein p53 Homo sapiens 90-93 27698914-5 2016 We provide experimental evidence and demonstrate that CAPE induced disruption of mortalin-p53 complexes led to nuclear translocation and activation of p53 resulting in growth arrest in cancer cells. caffeic acid phenethyl ester 54-58 tumor protein p53 Homo sapiens 151-154 25788262-0 2015 Caffeic acid phenethyl ester induced cell cycle arrest and growth inhibition in androgen-independent prostate cancer cells via regulation of Skp2, p53, p21Cip1 and p27Kip1. caffeic acid phenethyl ester 0-28 tumor protein p53 Homo sapiens 147-150 26184141-4 2015 In fact, CAPE is well documented as inducing cell death by inhibiting NFkappaB and by inducing pro-apoptotic pathways (i.e., p53). caffeic acid phenethyl ester 9-13 tumor protein p53 Homo sapiens 125-128 26184141-9 2015 Similarly to CAPE, analog compounds elicited p53 activation. caffeic acid phenethyl ester 13-17 tumor protein p53 Homo sapiens 45-48 26184141-11 2015 These results suggest that our new CAPE analog compounds may display the capacity to induce breast cancer apoptosis in a p53-dependent and/or independent manner. caffeic acid phenethyl ester 35-39 tumor protein p53 Homo sapiens 121-124 26184141-12 2015 These CAPE analogs could thus provide new therapeutic approaches for patients with varying genotypic signatures (such as p53 mutations) in a more specific and targeted fashion. caffeic acid phenethyl ester 6-10 tumor protein p53 Homo sapiens 121-124 25788262-6 2015 Overexpression of Skp2, or siRNA knockdown of p21Cip1, p27Kip1, or p53 blocked suppressive effect of CAPE treatment. caffeic acid phenethyl ester 101-105 tumor protein p53 Homo sapiens 67-70 25788262-8 2015 Our finding suggested that CAPE treatment induced cell cycle arrest and growth inhibition in CRPC cells via regulation of Skp2, p53, p21Cip1, and p27Kip1. caffeic acid phenethyl ester 27-31 tumor protein p53 Homo sapiens 128-131 22692362-8 2012 Caffeic acid phenethyl ester, an antioxidant, prevented the As-induced decreases in SOD1, p53, and ferritin mRNA and protein levels. caffeic acid phenethyl ester 0-28 tumor protein p53 Homo sapiens 90-93 24997497-2 2014 Previously, our laboratory demonstrated the in vitro and in vivo bioactivity of CAPE and addressed the role of p53 and the p38 mitogen-activated protein kinase (MAPK) pathway in regulating CAPE-induced apoptosis in C6 glioma cells. caffeic acid phenethyl ester 189-193 tumor protein p53 Homo sapiens 111-114 17204746-0 2007 Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor kappaB responses and cell death are altered by caffeic acid phenethyl ester: a potential role for antioxidant/electrophilic response-element signaling. caffeic acid phenethyl ester 121-149 tumor protein p53 Homo sapiens 38-41 17204746-7 2007 CAPE disrupted BFA-induced phosphorylation of p53 and p90 ribosomal S6 kinase (p90RSK) in both cell lines. caffeic acid phenethyl ester 0-4 tumor protein p53 Homo sapiens 46-49