PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29864436-0 2018 Caffeic acid phenethyl ester promotes wound healing of mice pressure ulcers affecting NF-kappaB, NOS2 and NRF2 expression. caffeic acid phenethyl ester 0-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 86-95 32377719-9 2020 In addition, the combined use of the specific NF-kappaB inhibitor caffeic acid phenethyl ester (CAPE) with CTX significantly enhanced CTX effect, both in vivo and in vitro. caffeic acid phenethyl ester 66-94 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 46-55 32377719-9 2020 In addition, the combined use of the specific NF-kappaB inhibitor caffeic acid phenethyl ester (CAPE) with CTX significantly enhanced CTX effect, both in vivo and in vitro. caffeic acid phenethyl ester 96-100 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 46-55 30464588-0 2018 Caffeic acid phenethyl ester attenuates neuropathic pain by suppressing the p38/NF-kappaB signal pathway in microglia. caffeic acid phenethyl ester 0-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 80-89 30464588-3 2018 Our present study investigated the effects and the possible mechanism of caffeic acid phenethyl ester (CAPE), the main ingredient of propolis, in improving neuropathic pain via its inhibition on p38/NF-kappaB signal pathway in microglia. caffeic acid phenethyl ester 73-101 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 199-208 30464588-3 2018 Our present study investigated the effects and the possible mechanism of caffeic acid phenethyl ester (CAPE), the main ingredient of propolis, in improving neuropathic pain via its inhibition on p38/NF-kappaB signal pathway in microglia. caffeic acid phenethyl ester 103-107 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 199-208 30464588-8 2018 Furthermore, CAPE suppressed the phosphorylation of p38 mitogen-activated protein kinase, inhibited the translocation of NF-kappaB and decreased the expression of proinflammatory cytokines tumor necrosis factor-alpha, IL-1beta and IL-6. caffeic acid phenethyl ester 13-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 121-130 30464588-9 2018 Conclusion: CAPE was found to be an effective and safe drug candidate for alleviating neuropathic pain by its powerful inhibition on the P38/NF-kappaB signal pathway. caffeic acid phenethyl ester 12-16 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 141-150 30037569-7 2018 These results suggest that CAPE has strong inhibitory effects on the NF-kappaB activation that are associated with the modification of thiol groups and phosphorylation of p65. caffeic acid phenethyl ester 27-31 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 69-78 29957360-7 2018 In addition, CAPE suppressed the expression of nuclear factor-kappa B (NF-kappaB p65), its translocation to the nucleus, and the activation of NF-kappaB inhibitor (IkappaBalpha) and its kinase (IKKbeta). caffeic acid phenethyl ester 13-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 71-80 29957360-9 2018 The expression of Nox1 was suppressed by CAPE through the down-regulation of IKKbeta/IkappaBalpha/NF-kappaB and JNK/AP-1 signal pathway. caffeic acid phenethyl ester 41-45 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 98-107 29957360-10 2018 This study provides evidence that the anti-osteoclastic effect of CAPE depends upon the attenuated superoxide anion production, which is closely related with interruption of an active Nox1 complex formation due to the attenuated catalytic subunit Nox1 expression resulting from suppression of the IKKbeta/IkappaBalpha/NF-kappaB and JNK/AP-1 signaling pathway and the down-regulation of the p47phox subunit translocation to the cell membrane. caffeic acid phenethyl ester 66-70 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 318-327 30037569-0 2018 Inhibition of nuclear factor-kappaB p65 phosphorylation by 3,4-dihydroxybenzalacetone and caffeic acid phenethyl ester. caffeic acid phenethyl ester 90-118 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 14-35 30037569-4 2018 Consistent with these results, induction of NF-kappaB downstream genes, such as Nitric oxide synthase, interleukin 1 beta, and interleukin 6, and translocation of NF-kappaB p65 to the nucleus were reduced after LPS stimulation, to a greater extent with CAPE than with DBL. caffeic acid phenethyl ester 253-257 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 44-53 29021196-5 2017 NF-kappaB inhibition with QNZ, caffeic acid phenethyl ester, or small interfering RNA (siRNA)-mediated silencing of NF-kappaB p65 attenuated high-NaCl-induced PRR upregulation. caffeic acid phenethyl ester 31-59 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 0-9 28528363-2 2018 Caffeic acid phenethyl ester (CAPE) is a naturally occurring anti-inflammatory agent, found in propolis, and has been reported as a specific inhibitor of NF-kappabeta. caffeic acid phenethyl ester 0-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 154-166 28528363-2 2018 Caffeic acid phenethyl ester (CAPE) is a naturally occurring anti-inflammatory agent, found in propolis, and has been reported as a specific inhibitor of NF-kappabeta. caffeic acid phenethyl ester 30-34 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 154-166 29383098-6 2017 In addition, the immunohistochemical and western blot results showed that CAPE and CAPE-pNO2 inhibited inflammation through the Akt/NF-kappaB pathway and prevented renal fibrosis through the TGF-beta/Smad pathway. caffeic acid phenethyl ester 74-78 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 132-141 24970360-9 2014 Pretreatment with 100 microM CAPE, an inhibitor of NF-kappaB, significantly inhibited TNF-alpha-induced IL-34 expression. caffeic acid phenethyl ester 29-33 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 51-60 28849197-5 2017 Caffeic acid phenethyl ester (CAPE) was used to inhibit the activation of NF-kappaB and examine the effect of the ASPP2/NF-kappabeta pathway on osteoblastic cell differentiation, proliferation and autophagy. caffeic acid phenethyl ester 0-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 74-83 28849197-5 2017 Caffeic acid phenethyl ester (CAPE) was used to inhibit the activation of NF-kappaB and examine the effect of the ASPP2/NF-kappabeta pathway on osteoblastic cell differentiation, proliferation and autophagy. caffeic acid phenethyl ester 30-34 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 74-83 27351827-8 2016 Dependence of CXCL2 expression on NF-kappaB was confirmed by the effect of an NF-kappaB inhibitor caffeic acid phenethyl ester that abolished LPS-induced CXCL2 expression. caffeic acid phenethyl ester 98-126 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 34-43 27351827-8 2016 Dependence of CXCL2 expression on NF-kappaB was confirmed by the effect of an NF-kappaB inhibitor caffeic acid phenethyl ester that abolished LPS-induced CXCL2 expression. caffeic acid phenethyl ester 98-126 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 78-87 23318275-9 2013 CAPE treatment decreased the inflammatory response as the expression of inducible nitric oxide synthase, inflammatory cytokine, and activation of NF-kappaB in Abcd1/Abcd2-silenced mouse primary astrocytes was reduced. caffeic acid phenethyl ester 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 146-155 24145059-8 2013 SA-induced upregulation of LOX-1 protein expression was clearly prevented by treatment with an antioxidant, N-acetylcysteine (NAC), or an NF-kappaB inhibitor, caffeic acid phenethylester (CAPE). caffeic acid phenethyl ester 159-186 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 138-147 22038897-0 2011 Catechols in caffeic acid phenethyl ester are essential for inhibition of TNF-mediated IP-10 expression through NF-kappaB-dependent but HO-1- and p38-independent mechanisms in mouse intestinal epithelial cells. caffeic acid phenethyl ester 13-41 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 112-121 34301977-8 2021 MDR1 down-regulation via the Akt/NF-kappaB pathway by celecoxib was confirmed, using an NF-kappaB inhibitor, CAPE. caffeic acid phenethyl ester 109-113 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 88-97 19285574-0 2009 Caffeic acid phenethyl ester inhibits osteoclastogenesis by suppressing NF kappaB and downregulating NFATc1 and c-Fos. caffeic acid phenethyl ester 0-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 72-81 16253780-9 2005 Radiation activated NF-kappaB was reversed by CAPE pretreatment. caffeic acid phenethyl ester 46-50 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 20-29 16253780-12 2005 CONCLUSIONS: CAPE sensitizes CT26 colorectal adenocarcinoma to IR, which may be via depleting GSH and inhibiting NF-kappaB activity, without toxicity to bone marrow, liver, and kidney. caffeic acid phenethyl ester 13-17 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 113-122 12010781-11 2002 In wildtype mice, inhibition of p38 or ERK1/2 MAPKs significantly reduced IL-1beta induced IL-6 release, whilst the NFkappaB inhibitor caffeic acid phenethyl ester (CAPE) modulated IL-1 induced IL-6 release by action on NFkappaB and MAPKs pathways. caffeic acid phenethyl ester 135-163 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 116-124 12010781-11 2002 In wildtype mice, inhibition of p38 or ERK1/2 MAPKs significantly reduced IL-1beta induced IL-6 release, whilst the NFkappaB inhibitor caffeic acid phenethyl ester (CAPE) modulated IL-1 induced IL-6 release by action on NFkappaB and MAPKs pathways. caffeic acid phenethyl ester 135-163 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 220-228 12010781-11 2002 In wildtype mice, inhibition of p38 or ERK1/2 MAPKs significantly reduced IL-1beta induced IL-6 release, whilst the NFkappaB inhibitor caffeic acid phenethyl ester (CAPE) modulated IL-1 induced IL-6 release by action on NFkappaB and MAPKs pathways. caffeic acid phenethyl ester 165-169 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 116-124 11734336-5 2002 CAPE also inhibited iNOS mRNA expression and nuclear factor-kappa B (NF-kappaB) binding activity in a concentration-dependent manner. caffeic acid phenethyl ester 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 45-67 11734336-5 2002 CAPE also inhibited iNOS mRNA expression and nuclear factor-kappa B (NF-kappaB) binding activity in a concentration-dependent manner. caffeic acid phenethyl ester 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 69-78 34743973-0 2021 MiR-182-5p/TLR4/NF-kappaB axis contributes to the protective effect of caffeic acid phenethyl ester against cadmium-induced spleen toxicity and associated damage in mice. caffeic acid phenethyl ester 71-99 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 16-25 34743973-9 2021 The antagonistic effect of CAPE against CdCl2-induced spleen toxicity was realized by increasing miR-182-5p expression to regulate the TLR4/NF-kappaB pathway. caffeic acid phenethyl ester 27-31 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 140-149 34743973-10 2021 Therefore, CAPE could be a food-derived spleen protector to counteract Cd-induced spleen toxicity through alleviating apoptosis and inflammation via the miR-182-5p/TLR4/NF-kappaB axis. caffeic acid phenethyl ester 11-15 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 169-178 21729740-6 2011 Cape+LPS treatment resulted in reduced translocation of NF-kappaB into the nucleus. caffeic acid phenethyl ester 0-4 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 56-65 21729740-10 2011 The present results suggest that Cape inhibits NF-kappaB activation through suppressing its interaction with DNA. caffeic acid phenethyl ester 33-37 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 47-56 19285574-5 2009 While the RANKL-stimulated activation of the ERK, JNK, and p38 MAPK signaling pathways was not affected, the DNA binding and transcription activity of NF kappaB were reduced by CAPE treatment. caffeic acid phenethyl ester 177-181 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 151-160 16336675-3 2005 To determine whether CAPE, an antioxidant and an inhibitor of NF-kappa B, could be a useful adjuvant agent for lung cancer treatment, we examine the effects of CAPE on irradiated normal lung tissue in this study. caffeic acid phenethyl ester 21-25 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 62-72 11734336-6 2002 Furthermore, transfection of RAW 264.7 cells with iNOS promoter linked to a chloramphenicol acetyltransferase reporter gene, revealed that CAPE inhibited the iNOS promoter activity induced by LPS plus IFN-gamma through the NF-kappaB sites of the iNOS promoter. caffeic acid phenethyl ester 139-143 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 223-232 11734336-8 2002 These results suggest that CAPE may exert its anti-inflammatory effect by inhibiting the iNOS gene expression at the transcriptional level through the suppression of NF-kappaB activation, and by directly inhibiting the catalytic activity of iNOS. caffeic acid phenethyl ester 27-31 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 166-175 35040047-0 2022 Caffeic Acid Phenethyl Ester Attenuates Dextran Sulfate Sodium-Induced Ulcerative Colitis Through Modulation of NF-kappaB and Cell Adhesion Molecules. caffeic acid phenethyl ester 0-28 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 112-121 35432586-3 2022 An active component of propolis, named caffeic acid phenethyl ester (CAPE), is recognized as an inhibitor of the NF-kappaB pathway and shows anti-inflammatory effect. caffeic acid phenethyl ester 39-67 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 113-122 35432586-3 2022 An active component of propolis, named caffeic acid phenethyl ester (CAPE), is recognized as an inhibitor of the NF-kappaB pathway and shows anti-inflammatory effect. caffeic acid phenethyl ester 69-73 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 113-122 35432586-13 2022 In conclusion, as an inhibitor of the NF-kappaB pathway, CAPE attenuated the release of TGF-beta1, which inhibited the fibrogenic progress induced by acrolein in mice and took no effect on inhibiting airway mucus hypersecretion. caffeic acid phenethyl ester 57-61 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 38-47