PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30909527-8	2019	Furthermore, CAPE inhibits hypoxia- and PDGF-BB-induced HIF-1alpha expression by decreasing the activation of the AKT/ERK pathway, which results in the inhibition of human pulmonary artery smooth muscle cells (hPASMCs) proliferation and prevention of cells resistant to apoptosis.	caffeic acid phenethyl ester	13-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	56-66	
26296470-7	2015	CAPE-mediated HIF-1alpha reduced 3-MC-inducible CYP1A1 protein expression.	caffeic acid phenethyl ester	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24	
26296470-0	2015	Caffeic acid phenethyl ester inhibits 3-MC-induced CYP1A1 expression through induction of hypoxia-inducible factor-1alpha.	caffeic acid phenethyl ester	0-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-121	
26296470-6	2015	CAPE induced hypoxia inducible factor-1alpha (HIF-1alpha) protein level and HIF-1alpha responsible element (HRE) transcriptional activity.	caffeic acid phenethyl ester	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-44	
26296470-6	2015	CAPE induced hypoxia inducible factor-1alpha (HIF-1alpha) protein level and HIF-1alpha responsible element (HRE) transcriptional activity.	caffeic acid phenethyl ester	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	46-56	
26296470-6	2015	CAPE induced hypoxia inducible factor-1alpha (HIF-1alpha) protein level and HIF-1alpha responsible element (HRE) transcriptional activity.	caffeic acid phenethyl ester	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86	
26296470-8	2015	Taken together, CAPE decreases 3-MC-mediated CYP1A1 expression, and this inhibitory response is associated with inhibition of AhR and HIF-1alpha induction.	caffeic acid phenethyl ester	16-20	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-144	
25738890-0	2015	Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1alpha signaling pathways in human retinal pigment epithelial cells under hypoxic conditions.	caffeic acid phenethyl ester	0-28	hypoxia inducible factor 1 subunit alpha	Homo sapiens	133-143	
25738890-9	2015	Pre-treatment with CAPE suppressed the hypoxia-induced production of VEGF in the ARPE-19 cells, and this effect was inhibited through the attenuation of reactive oxygen species (ROS) production, and the inhibition of phosphoinositide 3-kinase (PI3K)/AKT and hypoxia-inducible factor-1alpha (HIF-1alpha) expression.	caffeic acid phenethyl ester	19-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	258-289	
25738890-9	2015	Pre-treatment with CAPE suppressed the hypoxia-induced production of VEGF in the ARPE-19 cells, and this effect was inhibited through the attenuation of reactive oxygen species (ROS) production, and the inhibition of phosphoinositide 3-kinase (PI3K)/AKT and hypoxia-inducible factor-1alpha (HIF-1alpha) expression.	caffeic acid phenethyl ester	19-23	hypoxia inducible factor 1 subunit alpha	Homo sapiens	291-301	
17213816-7	2007	Two modulators of the Akt/NF-kappaB pathway, caffeic acid phenethyl ester and evodiamine, were observed to decrease HIF-1alpha expression.	caffeic acid phenethyl ester	45-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	116-126	
24448906-8	2014	CAPE appears to induce HSPC expansion by upregulating the expression of SCF and HIF1-alpha.	caffeic acid phenethyl ester	0-4	hypoxia inducible factor 1 subunit alpha	Homo sapiens	80-90