PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20599928-0 2010 Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: structural analysis for NFkappaB inhibition. caffeic acid phenethyl ester 0-28 NFE2 like bZIP transcription factor 2 Homo sapiens 38-42 25007817-0 2014 Nrf2-mediated HO-1 induction coupled with the ERK signaling pathway contributes to indirect antioxidant capacity of caffeic acid phenethyl ester in HepG2 cells. caffeic acid phenethyl ester 116-144 NFE2 like bZIP transcription factor 2 Homo sapiens 0-4 25007817-1 2014 The objective of this study is to investigate the contributing effect of the nuclear transcription factor-erythroid 2-related factor 2 (Nrf2)-mediated signaling pathway on the indirect antioxidant capacity of caffeic acid phenethyl ester (CAPE) against oxidative stress in HepG2 cells. caffeic acid phenethyl ester 209-237 NFE2 like bZIP transcription factor 2 Homo sapiens 77-134 25007817-1 2014 The objective of this study is to investigate the contributing effect of the nuclear transcription factor-erythroid 2-related factor 2 (Nrf2)-mediated signaling pathway on the indirect antioxidant capacity of caffeic acid phenethyl ester (CAPE) against oxidative stress in HepG2 cells. caffeic acid phenethyl ester 209-237 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 25007817-1 2014 The objective of this study is to investigate the contributing effect of the nuclear transcription factor-erythroid 2-related factor 2 (Nrf2)-mediated signaling pathway on the indirect antioxidant capacity of caffeic acid phenethyl ester (CAPE) against oxidative stress in HepG2 cells. caffeic acid phenethyl ester 239-243 NFE2 like bZIP transcription factor 2 Homo sapiens 77-134 25007817-1 2014 The objective of this study is to investigate the contributing effect of the nuclear transcription factor-erythroid 2-related factor 2 (Nrf2)-mediated signaling pathway on the indirect antioxidant capacity of caffeic acid phenethyl ester (CAPE) against oxidative stress in HepG2 cells. caffeic acid phenethyl ester 239-243 NFE2 like bZIP transcription factor 2 Homo sapiens 136-140 25007817-3 2014 In addition, CAPE treatment enhanced Nrf2 accumulation in the nucleus and the post-translational phosphorylation level of extracellular signal-regulated kinase (ERK) among several protein kinases tested. caffeic acid phenethyl ester 13-17 NFE2 like bZIP transcription factor 2 Homo sapiens 37-41 25007817-4 2014 Treatment with ERK inhibitor U126 completely suppressed CAPE-induced ERK phosphorylation and HO-1 expression, but it only partly inhibited CAPE-induced Nrf2 accumulation and ARE promoter. caffeic acid phenethyl ester 139-143 NFE2 like bZIP transcription factor 2 Homo sapiens 152-156 25007817-6 2014 From the overall results it is proposed that the indirect antioxidant activity of CAPE against oxidative stress in HepG2 cells is partially attributed to induction of HO-1, which is regulated by Kelch-like erythroid-cell-derived protein with CNC homology (ECH)-associated protein 1 (Keap1)-independent Nrf2 activation relying on post-translational phosphorylation of ERK. caffeic acid phenethyl ester 82-86 NFE2 like bZIP transcription factor 2 Homo sapiens 302-306 24703885-7 2014 Pathway analysis results showed that transcription factor Nrf2-mediated oxidative stress response was among the top canonical pathways commonly activated by both CDDO-Im and CAPE. caffeic acid phenethyl ester 174-178 NFE2 like bZIP transcription factor 2 Homo sapiens 58-62 20599928-5 2010 CAPE increased the expression of Nrf2-dependent luciferase and heme oxygenase-1, a target gene of Nrf2, and elevated the nuclear level of Nrf2 protein, indicating that CAPE activated the Nrf2 pathway. caffeic acid phenethyl ester 168-172 NFE2 like bZIP transcription factor 2 Homo sapiens 33-37 20599928-5 2010 CAPE increased the expression of Nrf2-dependent luciferase and heme oxygenase-1, a target gene of Nrf2, and elevated the nuclear level of Nrf2 protein, indicating that CAPE activated the Nrf2 pathway. caffeic acid phenethyl ester 168-172 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 20599928-5 2010 CAPE increased the expression of Nrf2-dependent luciferase and heme oxygenase-1, a target gene of Nrf2, and elevated the nuclear level of Nrf2 protein, indicating that CAPE activated the Nrf2 pathway. caffeic acid phenethyl ester 168-172 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 20599928-5 2010 CAPE increased the expression of Nrf2-dependent luciferase and heme oxygenase-1, a target gene of Nrf2, and elevated the nuclear level of Nrf2 protein, indicating that CAPE activated the Nrf2 pathway. caffeic acid phenethyl ester 168-172 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 20599928-6 2010 In HCT116 cells with stable expression of Nrf2 shRNA, CAPE elicited a reduced inhibitory effect on TNF-alpha-activated NFsmall ka, CyrillicB compared to scramble RNA expressing control cells. caffeic acid phenethyl ester 54-58 NFE2 like bZIP transcription factor 2 Homo sapiens 42-46 20599928-8 2010 These data suggest that CAPE inhibits TNF-alpha-dependent NFkappaB activation via direct inhibition of IKK as well as activation of Nrf2 pathway, in which the functional groups in CAPE may be involved. caffeic acid phenethyl ester 24-28 NFE2 like bZIP transcription factor 2 Homo sapiens 132-136 20599928-5 2010 CAPE increased the expression of Nrf2-dependent luciferase and heme oxygenase-1, a target gene of Nrf2, and elevated the nuclear level of Nrf2 protein, indicating that CAPE activated the Nrf2 pathway. caffeic acid phenethyl ester 0-4 NFE2 like bZIP transcription factor 2 Homo sapiens 33-37 20599928-5 2010 CAPE increased the expression of Nrf2-dependent luciferase and heme oxygenase-1, a target gene of Nrf2, and elevated the nuclear level of Nrf2 protein, indicating that CAPE activated the Nrf2 pathway. caffeic acid phenethyl ester 0-4 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 20599928-5 2010 CAPE increased the expression of Nrf2-dependent luciferase and heme oxygenase-1, a target gene of Nrf2, and elevated the nuclear level of Nrf2 protein, indicating that CAPE activated the Nrf2 pathway. caffeic acid phenethyl ester 0-4 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 20599928-5 2010 CAPE increased the expression of Nrf2-dependent luciferase and heme oxygenase-1, a target gene of Nrf2, and elevated the nuclear level of Nrf2 protein, indicating that CAPE activated the Nrf2 pathway. caffeic acid phenethyl ester 0-4 NFE2 like bZIP transcription factor 2 Homo sapiens 98-102 12570874-9 2003 Taken together, these results demonstrate that induction of HO-1 by curcumin and CAPE requires the activation of the Nrf2/ARE pathway. caffeic acid phenethyl ester 81-85 NFE2 like bZIP transcription factor 2 Homo sapiens 117-121 12570874-5 2003 Here, we show that in renal epithelial cells both curcumin and CAPE stimulate the expression of Nrf2 in a concentration- and time-dependent manner. caffeic acid phenethyl ester 63-67 NFE2 like bZIP transcription factor 2 Homo sapiens 96-100 31885818-0 2019 FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling. caffeic acid phenethyl ester 23-51 NFE2 like bZIP transcription factor 2 Homo sapiens 190-194 28618991-11 2018 In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1). caffeic acid phenethyl ester 76-104 NFE2 like bZIP transcription factor 2 Homo sapiens 135-178 28618991-11 2018 In particular, some polyphenols such as curcumin, quercetin, genistein, and caffeic acid phenethyl ester are able to potently activate nuclear factor erythroid 2-related factor 2 (Nrf2) and related downstream expression of enzymes such as heme oxygenase-1 (HO-1). caffeic acid phenethyl ester 76-104 NFE2 like bZIP transcription factor 2 Homo sapiens 180-184