PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
35197069-14	2022	CONCLUSIONS: Combination treatment of docetaxel with CAPE effectively suppressed the proliferation and survival of docetaxel-resistant PCa cells via inhibition of Bcl-2 and c-Myc as well as induction of metabolism interference.	caffeic acid phenethyl ester	53-57	BCL2 apoptosis regulator	Homo sapiens	163-168	
32752091-0	2020	Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes.	caffeic acid phenethyl ester	0-28	BCL2 apoptosis regulator	Homo sapiens	108-112	
32634439-10	2020	In addition, 150 muM 6-OHDA-induced down-regulation of Bcl-2 and Akt levels and up-regulation of Bax and cleaved caspase-9/caspase-9 levels were partially restored by 1.25 muM CAPE treatment.	caffeic acid phenethyl ester	176-180	BCL2 apoptosis regulator	Homo sapiens	55-60	
32752091-0	2020	Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes.	caffeic acid phenethyl ester	30-34	BCL2 apoptosis regulator	Homo sapiens	108-112	
32752091-6	2020	The cytotoxic and proapoptotic activity of CAPE was investigated by using the XTT-NR-SRB assay, qRT-PCR analysis of BAX/BCL2 expression, and by cytometric evaluation.	caffeic acid phenethyl ester	43-47	BCL2 apoptosis regulator	Homo sapiens	120-124	
32752091-11	2020	In OV7 cells CAPE induced apoptosis via dysregulation of BAX/BCL2 balance, while activated proapoptotic BAX gene expression level was 10 times higher than BCL2.	caffeic acid phenethyl ester	13-17	BCL2 apoptosis regulator	Homo sapiens	61-65	
26697130-4	2016	MCF-7 cells were treated with different concentrations of TAM and/or CAPE for 48 h. This novel combination exerted synergistic cytotoxic effects against MCF-7 cells via induction of apoptotic machinery with activation of caspases and DNA fragmentation, along with downregulation of Bcl-2 and Beclin 1 expression levels.	caffeic acid phenethyl ester	69-73	BCL2 apoptosis regulator	Homo sapiens	282-287	
19358267-8	2009	Bax expression was increased, whereas Bcl-2 was decreased in cells treated with CAPE compared to vehicle.	caffeic acid phenethyl ester	80-84	BCL2 apoptosis regulator	Homo sapiens	38-43	
11714368-6	2001	Treatment with CAPE caused rapid activation of caspase-3 after 4 h, down-regulation of Bcl-2 expression after 6 h, and up-regulation of Bax expression after 16 h. These results suggest that CAPE is a potent apoptosis-inducing agent; its action is accompanied by activation of caspase-3, down-regulation of Bcl-2, and up-regulation of Bax in human leukemic HL-60 cells.	caffeic acid phenethyl ester	15-19	BCL2 apoptosis regulator	Homo sapiens	87-92	
11714368-6	2001	Treatment with CAPE caused rapid activation of caspase-3 after 4 h, down-regulation of Bcl-2 expression after 6 h, and up-regulation of Bax expression after 16 h. These results suggest that CAPE is a potent apoptosis-inducing agent; its action is accompanied by activation of caspase-3, down-regulation of Bcl-2, and up-regulation of Bax in human leukemic HL-60 cells.	caffeic acid phenethyl ester	15-19	BCL2 apoptosis regulator	Homo sapiens	306-311	
11714368-6	2001	Treatment with CAPE caused rapid activation of caspase-3 after 4 h, down-regulation of Bcl-2 expression after 6 h, and up-regulation of Bax expression after 16 h. These results suggest that CAPE is a potent apoptosis-inducing agent; its action is accompanied by activation of caspase-3, down-regulation of Bcl-2, and up-regulation of Bax in human leukemic HL-60 cells.	caffeic acid phenethyl ester	190-194	BCL2 apoptosis regulator	Homo sapiens	87-92	
11714368-6	2001	Treatment with CAPE caused rapid activation of caspase-3 after 4 h, down-regulation of Bcl-2 expression after 6 h, and up-regulation of Bax expression after 16 h. These results suggest that CAPE is a potent apoptosis-inducing agent; its action is accompanied by activation of caspase-3, down-regulation of Bcl-2, and up-regulation of Bax in human leukemic HL-60 cells.	caffeic acid phenethyl ester	190-194	BCL2 apoptosis regulator	Homo sapiens	306-311	
23430344-8	2014	CAPE and both chemotherapeutic agents reduced Bcl-2, while only CAPE and MG132 significantly increased Bax level.	caffeic acid phenethyl ester	0-4	BCL2 apoptosis regulator	Homo sapiens	46-51