PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26557918-1 2015 BACKGROUND: Micro ribonucleic acid (miR-101) can regulate the expression of cyclooxygenase-2 (COX-2) and participate in the pathogenesis of malignant tumors. mir-101 36-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 76-92 27698824-0 2016 miR-101 inhibits glioma cell invasion via the downregulation of COX-2. mir-101 0-7 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-69 27698824-4 2016 The role of miR-101 on COX-2 expression was evaluated by a dual-luciferase reporter assay. mir-101 12-19 prostaglandin-endoperoxide synthase 2 Homo sapiens 23-28 27698824-7 2016 Furthermore, transfection of miR-101 significantly downregulated COX-2 expression in both U373 and U87 glioma cells. mir-101 29-36 prostaglandin-endoperoxide synthase 2 Homo sapiens 65-70 27698824-10 2016 These results indicate that downregulation of miR-101 is involved in the initiation and development of glioma via COX-2 upregulation. mir-101 46-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 114-119 26557918-1 2015 BACKGROUND: Micro ribonucleic acid (miR-101) can regulate the expression of cyclooxygenase-2 (COX-2) and participate in the pathogenesis of malignant tumors. mir-101 36-43 prostaglandin-endoperoxide synthase 2 Homo sapiens 94-99 26557918-7 2015 Correlation analysis revealed that miR-101 negatively correlated with COX-2 in lung cancer tissues (R = -0.596, P = 0.002). mir-101 35-42 prostaglandin-endoperoxide synthase 2 Homo sapiens 70-75 26557918-8 2015 Compared with A549-miR-NC cells, the expression of COX-2 was significantly decreased in A549 cells transfected with miR-101 (P < 0.001). mir-101 116-123 prostaglandin-endoperoxide synthase 2 Homo sapiens 51-56 25109742-0 2014 Enforced expression of miR-101 enhances cisplatin sensitivity in human bladder cancer cells by modulating the cyclooxygenase-2 pathway. mir-101 23-30 prostaglandin-endoperoxide synthase 2 Homo sapiens 110-126 25109742-8 2014 In addition, downregulation of miR-101 induced cell survival and cisplatin resistance through the upregulation of COX-2 expression. mir-101 31-38 prostaglandin-endoperoxide synthase 2 Homo sapiens 114-119 25109742-10 2014 Inhibition of COX-2 using COX-2 siRNA abrogated the cisplatin resistance induced by miR-101 downregulation. mir-101 84-91 prostaglandin-endoperoxide synthase 2 Homo sapiens 14-19 25109742-10 2014 Inhibition of COX-2 using COX-2 siRNA abrogated the cisplatin resistance induced by miR-101 downregulation. mir-101 84-91 prostaglandin-endoperoxide synthase 2 Homo sapiens 26-31 25109742-11 2014 These results suggest that miR-101 may provide a novel mechanism for understanding cisplatin resistance in bladder cancer by modulating the COX-2 pathway. mir-101 27-34 prostaglandin-endoperoxide synthase 2 Homo sapiens 140-145 23013439-0 2012 Downregulation of miR-101 in gastric cancer correlates with cyclooxygenase-2 overexpression and tumor growth. mir-101 18-25 prostaglandin-endoperoxide synthase 2 Homo sapiens 60-76 24958470-7 2014 Interestingly, cyclooxygenase-2 inhibition by aspirin or celecoxib abrogated IL-1beta-mediated repression of miR-101 and IL-1beta-mediated activation of Lin28B along with their stimulatory effects on NSCLC cell proliferation and migration. mir-101 109-116 prostaglandin-endoperoxide synthase 2 Homo sapiens 15-31 23013439-4 2012 Here, we characterize miR-101 expression and its role in the regulation of COX-2 expression, which in turn, will provide us with additional insights into the potential therapeutic benefits of exogenous miR-101 for treatment of gastric cancer. mir-101 22-29 prostaglandin-endoperoxide synthase 2 Homo sapiens 75-80 23013439-4 2012 Here, we characterize miR-101 expression and its role in the regulation of COX-2 expression, which in turn, will provide us with additional insights into the potential therapeutic benefits of exogenous miR-101 for treatment of gastric cancer. mir-101 202-209 prostaglandin-endoperoxide synthase 2 Homo sapiens 75-80 23013439-7 2012 We also found an inverse correlation between miR-101 and COX-2 expression in both gastric cancer specimens and cell lines. mir-101 45-52 prostaglandin-endoperoxide synthase 2 Homo sapiens 57-62 23013439-8 2012 Significant decreases in COX-2 mRNA and COX-2 levels were observed in the pre-miR-101-infected gastric cancer cells. mir-101 78-85 prostaglandin-endoperoxide synthase 2 Homo sapiens 25-30 23013439-8 2012 Significant decreases in COX-2 mRNA and COX-2 levels were observed in the pre-miR-101-infected gastric cancer cells. mir-101 78-85 prostaglandin-endoperoxide synthase 2 Homo sapiens 40-45 23013439-9 2012 One possible mechanism of interaction is that miR-101 inhibited COX-2 expression by directly binding to the 3"-UTR of COX-2 mRNA. mir-101 46-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-69 23013439-9 2012 One possible mechanism of interaction is that miR-101 inhibited COX-2 expression by directly binding to the 3"-UTR of COX-2 mRNA. mir-101 46-53 prostaglandin-endoperoxide synthase 2 Homo sapiens 118-123 29404887-5 2018 Finally, we determined if miR-101 regulated tumorigenesis through cyclooxygenase-2 (COX-2). mir-101 26-33 prostaglandin-endoperoxide synthase 2 Homo sapiens 66-82 19891660-11 2010 Moreover, strong positive immunoreactivity of cyclooxygenase-2 (COX-2) was significantly correlated with down-regulation of miR-101 (P = 0.035). mir-101 124-131 prostaglandin-endoperoxide synthase 2 Homo sapiens 46-62 19891660-11 2010 Moreover, strong positive immunoreactivity of cyclooxygenase-2 (COX-2) was significantly correlated with down-regulation of miR-101 (P = 0.035). mir-101 124-131 prostaglandin-endoperoxide synthase 2 Homo sapiens 64-69 19133256-0 2009 MiR-101 downregulation is involved in cyclooxygenase-2 overexpression in human colon cancer cells. mir-101 0-7 prostaglandin-endoperoxide synthase 2 Homo sapiens 38-54 19133256-4 2009 In this paper, we report the inverse correlation between COX-2 and miR-101 expression in colon cancer cell lines and we demonstrated in vitro the direct inhibition of COX-2 mRNA translation mediated by miR-101. mir-101 67-74 prostaglandin-endoperoxide synthase 2 Homo sapiens 57-62 19133256-4 2009 In this paper, we report the inverse correlation between COX-2 and miR-101 expression in colon cancer cell lines and we demonstrated in vitro the direct inhibition of COX-2 mRNA translation mediated by miR-101. mir-101 67-74 prostaglandin-endoperoxide synthase 2 Homo sapiens 167-172 19133256-6 2009 These findings provide a novel molecular insight in the modulation of COX-2 at post-transcriptional level by miR-101 and strengthen the observation that miRNAs are highly implicated in the control of gene expression. mir-101 109-116 prostaglandin-endoperoxide synthase 2 Homo sapiens 70-75 19133256-7 2009 An impairment of miR-101 levels could represent one of the leading causes of COX-2 overexpression in colon cancer cells. mir-101 17-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 77-82 32783891-11 2021 The use of mimic miR-101 (mi101) to induce the expression of miR-101 eventually leads to reduced COX-2 protein levels, relieved ER stress, and less abnormal angiogenesis and cytotoxicity of CdCl2-exposed primary HUVECs. mir-101 17-24 prostaglandin-endoperoxide synthase 2 Homo sapiens 97-102 32783891-11 2021 The use of mimic miR-101 (mi101) to induce the expression of miR-101 eventually leads to reduced COX-2 protein levels, relieved ER stress, and less abnormal angiogenesis and cytotoxicity of CdCl2-exposed primary HUVECs. mir-101 61-68 prostaglandin-endoperoxide synthase 2 Homo sapiens 97-102 29404887-5 2018 Finally, we determined if miR-101 regulated tumorigenesis through cyclooxygenase-2 (COX-2). mir-101 26-33 prostaglandin-endoperoxide synthase 2 Homo sapiens 84-89 29404887-9 2018 Finally, we found that the effects of miR-101 inhibition on tumor growth were suppressed by COX-2 inhibition. mir-101 38-45 prostaglandin-endoperoxide synthase 2 Homo sapiens 92-97