PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31230155-6	2019	100 mg/kg salidroside for 1 day increased NeuN, Nrf2, and its downstream mediator HO-1, while it reduced nuclear NFkappaB p50, IL-6, and TNFalpha.	rhodioloside	10-21	heme oxygenase 1	Rattus norvegicus	82-86	
34532015-7	2021	Furthermore, salidroside treatment also potentiated the activation of Nrf2-mediated anti-oxidant pathway, as indicated by upregulation of n-Nrf2 and its downstream HO-1 and NQO-1.	rhodioloside	13-24	heme oxygenase 1	Rattus norvegicus	164-168	
26889188-4	2015	Furthermore, salidroside apparently increased Nrf2 and heme oxygenase-1 expression.	rhodioloside	13-24	heme oxygenase 1	Rattus norvegicus	55-71	
30848530-0	2019	Neuroprotective effect of salidroside against central nervous system inflammation-induced cognitive deficits: A pivotal role of sirtuin 1-dependent Nrf-2/HO-1/NF-kappaB pathway.	rhodioloside	26-37	heme oxygenase 1	Rattus norvegicus	154-158	
30848530-10	2019	Together, our results showed that salidroside may be a novel therapy drug in neurodegenerative diseases, and the protective effect was involved in SIRT1-dependent Nrf-2/HO-1/NF-kappaB pathway.	rhodioloside	34-45	heme oxygenase 1	Rattus norvegicus	169-173	
25063033-5	2014	Meanwhile, salidroside activated Akt and promoted transcription of NF-E2-related factor 2 (Nrf2)-regulated genes (heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO-1)).	rhodioloside	11-22	heme oxygenase 1	Rattus norvegicus	114-130	
25063033-5	2014	Meanwhile, salidroside activated Akt and promoted transcription of NF-E2-related factor 2 (Nrf2)-regulated genes (heme oxygenase-1 (HO-1) and quinone oxidoreductase 1 (NQO-1)).	rhodioloside	11-22	heme oxygenase 1	Rattus norvegicus	132-136	
25063033-6	2014	Significantly, Nrf2 shRNA knockdown or Akt inhibitors (LY 294002 and wortmannin) not only prevented salidroside-induced HO-1/NQO-1 transcription, but also alleviated salidroside-mediated cytoprotective effect against OGD/re-oxygenation in H9c2 cells.	rhodioloside	100-111	heme oxygenase 1	Rattus norvegicus	120-124