PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34634782-0 2022 Salidroside Mitigates Airway Inflammation in Asthmatic Mice via the AMPK/Akt/GSK3beta Signaling Pathway. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 73-76 34634782-11 2022 Moreover, after the mice were treated with SAL, the phosphorylation level of AMPK was significantly increased, which further reduced the phosphorylation levels of Akt and GSK3beta (p < 0.05). rhodioloside 43-46 thymoma viral proto-oncogene 1 Mus musculus 163-166 34056772-9 2021 In Conclusion, salidroside not only improved diabetes, but also ameliorated diabetic cardiomyopathy, which was at least partly associated with the activation of mitochondrial SIRT3, AMPK/Akt, and PGC-1alpha/TFAM and subsequent improving mitochondrial function. rhodioloside 15-26 thymoma viral proto-oncogene 1 Mus musculus 187-190 34374127-0 2021 Neuroprotective effects of salidroside on ageing hippocampal neurons and naturally ageing mice via the PI3K/Akt/TERT pathway. rhodioloside 27-38 thymoma viral proto-oncogene 1 Mus musculus 108-111 34374127-7 2021 Salidroside promoted telomerase reverse transcriptase (TERT) protein expression via the phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt) pathway. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 143-146 34296587-9 2021 As compared with the normal group, the protein expressions of ColI, alpha-SMA, FN, CXCL16, and p-Akt in the model group were significantly increased, and salidroside could reduce the expression of these indicators(P<0.05 or P<0.01). rhodioloside 154-165 thymoma viral proto-oncogene 1 Mus musculus 97-100 34296587-11 2021 As compared with the model group, salidroside could inhibit the migration of JS 1 induced by CXCL16(P<0.05), and reduce the high expression of ColI and alpha-SMA mRNA and the phosphorylation of Akt in JS 1 induced by CXCL16(P<0.05). rhodioloside 34-45 thymoma viral proto-oncogene 1 Mus musculus 194-197 34054552-10 2021 In addition, Sal was also observed to subdue Col I expression, AKT activation, and LX-2 migration induced by exosomal SphK1 from SK-HEP-1 (a kind of liver sinusoidal endothelial cells (LSEC) cell line). rhodioloside 13-16 thymoma viral proto-oncogene 1 Mus musculus 63-66 34054552-12 2021 In vitro, it was observed that Sal might alleviate LX-2 migration and activation induced by exosomal SphK1 by inhibiting the AKT activation. rhodioloside 31-34 thymoma viral proto-oncogene 1 Mus musculus 125-128 33422954-0 2021 Salidroside protects against cardiomyocyte apoptosis and ventricular remodeling by AKT/HO-1 signaling pathways in a diabetic cardiomyopathy mouse model. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 83-86 33422954-12 2021 This cardio-protective effect of salidroside is dependent on AKT signaling activation. rhodioloside 33-44 thymoma viral proto-oncogene 1 Mus musculus 61-64 33389472-0 2021 Salidroside Inhibits Reactive Astrogliosis and Glial Scar Formation in Late Cerebral Ischemia via the Akt/GSK-3beta Pathway. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 102-105 33389472-11 2021 Western blot analysis demonstrated that salidroside attenuated the CM-OGD-induced upregulation of phosphorylated Akt and glycogen synthase kinase 3beta (GSK-3beta). rhodioloside 40-51 thymoma viral proto-oncogene 1 Mus musculus 113-116 33389472-12 2021 Taken together, these results suggested that salidroside can inhibit reactive astrocyte proliferation, ameliorate glial scar formation and improve long-term recovery, probably through its effects on the Akt/GSK-3beta pathway. rhodioloside 45-56 thymoma viral proto-oncogene 1 Mus musculus 203-206 33422954-10 2021 Mechanistically, salidroside markedly up-regulates HO-1 expression by activation of the AKT signaling pathway. rhodioloside 17-28 thymoma viral proto-oncogene 1 Mus musculus 88-91 32352928-0 2020 Salidroside inhibits platelet function and thrombus formation through AKT/GSK3beta signaling pathway. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 70-73 32002777-3 2020 In the present study, daily doses of Sal were administered to APP/PS1 mice, a mouse model of AD, and several parameters were tested, including behavioral performance, Abeta status, levels of synapse-related proteins, and levels of PI3K/Akt targets of mTOR cell signaling pathway proteins. rhodioloside 37-40 thymoma viral proto-oncogene 1 Mus musculus 236-239 32002777-6 2020 The phosphatidylinositide PI3K/Akt/mTOR signaling was upregulated, which was in accordance with the above improvements from Sal treatment. rhodioloside 124-127 thymoma viral proto-oncogene 1 Mus musculus 31-34 32352928-9 2020 Moreover, in thrombin-stimulated platelets, salidroside inhibited phosphorylation of AKT (T308/S473) and GSK3beta (Ser9). rhodioloside 44-55 thymoma viral proto-oncogene 1 Mus musculus 85-88 30840958-10 2019 Besides, the levels of PI3K and p-protein kinase B (Akt) in renal tissues were significantly decreased after SAL injection. rhodioloside 109-112 thymoma viral proto-oncogene 1 Mus musculus 52-55 31792327-9 2019 SAL down-regulated the expression levels of TNF-alpha, TGF-beta1, IL-1beta, Bax and up-regulate the expression of Bcl-2, VEGF, Akt and eNOS. rhodioloside 0-3 thymoma viral proto-oncogene 1 Mus musculus 127-130 30114387-0 2018 Salidroside alleviates ischemic brain injury in mice with ischemic stroke through regulating BDNK mediated PI3K/Akt pathway. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 112-115 30114387-7 2018 Furthermore, the neuroprotective effect of Sal on BDNK was mediated by PI3K/Akt pathway, which was proved by the use of PI3K knockout (PI3K-/-) mice and siRNA-PI3K. rhodioloside 43-46 thymoma viral proto-oncogene 1 Mus musculus 76-79 30114387-8 2018 In summary, these data strongly suggested that Sal could be used as an effective neuroprotective agent to protect against ischemic stroke after cerebral I/R injury through regulating BDNK-mediated PI3K/Akt apoptotic pathway in DNA-binding-dependent and -independent manners. rhodioloside 47-50 thymoma viral proto-oncogene 1 Mus musculus 202-205 29805476-8 2018 Sal suppressed inflammatory reactions in serum and liver tissues, and activated the PI3K/Akt signaling pathway to inhibit apoptosis and autophagy in vivo and in vitro, which could be reversed by LY294002. rhodioloside 0-3 thymoma viral proto-oncogene 1 Mus musculus 89-92 29093682-8 2017 This deleterious result was reversed by salidroside by activating AMPK-AKT to inhibit FOXO1 and recover PDX1 nuclear localization. rhodioloside 40-51 thymoma viral proto-oncogene 1 Mus musculus 71-74 25754463-0 2015 Salidroside ameliorates insulin resistance through activation of a mitochondria-associated AMPK/PI3K/Akt/GSK3beta pathway. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 101-104 27738547-0 2016 Neuroprotective Effects of Salidroside in the MPTP Mouse Model of Parkinson"s Disease: Involvement of the PI3K/Akt/GSK3beta Pathway. rhodioloside 27-38 thymoma viral proto-oncogene 1 Mus musculus 111-114 27738547-2 2016 Our in vitro experiments suggested that salidroside (Sal) could protect against 1-methyl-4-phenylpyridine-induced cell apoptosis in part by regulating the PI3K/Akt/GSK3beta pathway. rhodioloside 40-51 thymoma viral proto-oncogene 1 Mus musculus 160-163 27738547-2 2016 Our in vitro experiments suggested that salidroside (Sal) could protect against 1-methyl-4-phenylpyridine-induced cell apoptosis in part by regulating the PI3K/Akt/GSK3beta pathway. rhodioloside 53-56 thymoma viral proto-oncogene 1 Mus musculus 160-163 27738547-7 2016 Furthermore, Sal could increase the phosphorylation level of Akt and GSK3beta, upregulate the ratio of Bcl-2/Bax, and inhibit the activation of caspase-3, caspase-6, and caspase-9. rhodioloside 13-16 thymoma viral proto-oncogene 1 Mus musculus 61-64 27738547-8 2016 These results show that Sal prevents the loss of dopaminergic neurons and the PI3K/Akt/GSK3beta pathway signaling pathway may have mediated the protection of Sal against MPTP, suggesting that Sal may be a potential candidate in neuroprotective treatment for PD. rhodioloside 24-27 thymoma viral proto-oncogene 1 Mus musculus 83-86 27738547-8 2016 These results show that Sal prevents the loss of dopaminergic neurons and the PI3K/Akt/GSK3beta pathway signaling pathway may have mediated the protection of Sal against MPTP, suggesting that Sal may be a potential candidate in neuroprotective treatment for PD. rhodioloside 158-161 thymoma viral proto-oncogene 1 Mus musculus 83-86 27738547-8 2016 These results show that Sal prevents the loss of dopaminergic neurons and the PI3K/Akt/GSK3beta pathway signaling pathway may have mediated the protection of Sal against MPTP, suggesting that Sal may be a potential candidate in neuroprotective treatment for PD. rhodioloside 158-161 thymoma viral proto-oncogene 1 Mus musculus 83-86 26187353-0 2015 Salidroside improves endothelial function and alleviates atherosclerosis by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 120-123 26187353-10 2015 Both AMPK inhibitor and AMPK small interfering RNA (siRNA) abolished SAL-induced Akt-Ser473 and eNOS-Ser1177 phosphorylation. rhodioloside 69-72 thymoma viral proto-oncogene 1 Mus musculus 81-84 26187353-11 2015 In contrast, LY294002, the PI3k/Akt pathway inhibitor, abolished SAL-induced phosphorylation and expression of eNOS. rhodioloside 65-68 thymoma viral proto-oncogene 1 Mus musculus 32-35 26187353-14 2015 The action of SAL to reduce atherosclerotic lesion formation may at least be attributed to its effect on improving endothelial function by promoting nitric oxide (NO) production, which was associated with mitochondrial depolarization and subsequent activation of the AMPK/PI3K/Akt/eNOS pathway. rhodioloside 14-17 thymoma viral proto-oncogene 1 Mus musculus 277-280 28831032-9 2017 Salidroside increased the expression level of phosphorylated Akt (p-Akt) and phosphorylated ILK (p-ILK), p-JNK, and p-ERK and localization of Nrf-2. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 61-64 28831032-9 2017 Salidroside increased the expression level of phosphorylated Akt (p-Akt) and phosphorylated ILK (p-ILK), p-JNK, and p-ERK and localization of Nrf-2. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 68-71 28831032-13 2017 ILK/Akt, JNK, ERK1/2, p38 MAPK, and Nrf-2 are involved in salidroside-decreased podocyte apoptosis in HG condition. rhodioloside 58-69 thymoma viral proto-oncogene 1 Mus musculus 4-7 25754463-10 2015 In vitro, salidroside dose-dependently induced an increase in the phosphorylations of AMPK and PI3K/Akt, as well as glycogen synthase kinase 3beta (GSK3beta) in hepatocytes. rhodioloside 10-21 thymoma viral proto-oncogene 1 Mus musculus 100-103 25754463-14 2015 CONCLUSIONS AND IMPLICATIONS: Salidroside exerts an antidiabetic effect by improving the cellular metabolic flux through the activation of a mitochondria-related AMPK/PI3K/Akt/GSK3beta pathway. rhodioloside 30-41 thymoma viral proto-oncogene 1 Mus musculus 172-175 24187831-0 2013 [Salidroside via ERK1/2 and PI3K/AKT/mTOR signal pathway induces mouse bone marrow mesenchymal stem cells differentiation into neural cells]. rhodioloside 1-12 thymoma viral proto-oncogene 1 Mus musculus 33-36 24187831-10 2013 It points out that SD can stimulate the ERK1/2 and PI3K/AKT/mTOR signal pathway to promote BMSCs differentiation into neural cells. rhodioloside 19-21 thymoma viral proto-oncogene 1 Mus musculus 56-59 23029230-0 2012 Salidroside improves behavioral and histological outcomes and reduces apoptosis via PI3K/Akt signaling after experimental traumatic brain injury. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 89-92 23029230-2 2012 The aim of this study was to investigate the effects of salidroside, a phenolic glycoside with potent anti-apoptotic properties, on behavioral and histological outcomes, brain edema, and apoptosis following experimental TBI and the possible involvement of the phosphoinositide 3-kinase/protein kinase B (PI3K)/Akt signaling pathway. rhodioloside 56-67 thymoma viral proto-oncogene 1 Mus musculus 310-313 23029230-11 2012 Salidroside increased phosphorylation of Akt on Ser473 and the mitochondrial Bcl-2/Bax ratio at day 1, and enhanced phosphorylation of Akt on Thr308 at day 3. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 41-44 23029230-11 2012 Salidroside increased phosphorylation of Akt on Ser473 and the mitochondrial Bcl-2/Bax ratio at day 1, and enhanced phosphorylation of Akt on Thr308 at day 3. rhodioloside 0-11 thymoma viral proto-oncogene 1 Mus musculus 135-138 23029230-15 2012 CONCLUSIONS/SIGNIFICANCE: Post-injury salidroside improved long-term behavioral and histological outcomes and reduced brain edema and apoptosis following TBI, at least partially via the PI3K/Akt signaling pathway. rhodioloside 38-49 thymoma viral proto-oncogene 1 Mus musculus 191-194