PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31401159-8	2019	Sal inhibited oxidative stress by upregulating SOD, GSH-Px and CAT while suppressing colonic apoptosis by downregulating the expression of Bax, caspase-3, and cleaved-caspase-3 and upregulating the expression of Bcl-2.	rhodioloside	0-3	B cell leukemia/lymphoma 2	Mus musculus	212-217	
32910486-7	2020	Furthermore, SAL was found to be able to inhibit PA-induced apoptosis that down-regulates cleaved caspase-3 and Bax expressions, while up-regulating Bcl-2 expression and up-regulates the Bcl-2/Bax ratio in glucosamine induced insulin resistance model.	rhodioloside	13-16	B cell leukemia/lymphoma 2	Mus musculus	149-154	
32910486-7	2020	Furthermore, SAL was found to be able to inhibit PA-induced apoptosis that down-regulates cleaved caspase-3 and Bax expressions, while up-regulating Bcl-2 expression and up-regulates the Bcl-2/Bax ratio in glucosamine induced insulin resistance model.	rhodioloside	13-16	B cell leukemia/lymphoma 2	Mus musculus	187-192	
31792327-9	2019	SAL down-regulated the expression levels of TNF-alpha, TGF-beta1, IL-1beta, Bax and up-regulate the expression of Bcl-2, VEGF, Akt and eNOS.	rhodioloside	0-3	B cell leukemia/lymphoma 2	Mus musculus	114-119	
23029230-11	2012	Salidroside increased phosphorylation of Akt on Ser473 and the mitochondrial Bcl-2/Bax ratio at day 1, and enhanced phosphorylation of Akt on Thr308 at day 3.	rhodioloside	0-11	B cell leukemia/lymphoma 2	Mus musculus	77-82	
16334562-2	2005	METHODS: The effect of salidroside on peripheral blood cells, BMCs, and bone marrow cell cycle in bone marrow depressed anemia mice was detected by automatic blood cell analysator, white blood count and flow cytometry (FCM)respectively,and the expression of Bcl-2 and Bax of BMCs was detected by immunohistochemistry method simultaneously.	rhodioloside	23-34	B cell leukemia/lymphoma 2	Mus musculus	258-263	
16334562-4	2005	Additionally, the expression of Bcl-2 in BMCs was increased in low-dose and high-dose salidroside groups, especially the increase was significant in the low-dose salidroside group; moreover, the expression of Bax in BMCs was reduced significantly in both low-dose and high-dose salidroside groups.	rhodioloside	86-97	B cell leukemia/lymphoma 2	Mus musculus	32-37	
16334562-4	2005	Additionally, the expression of Bcl-2 in BMCs was increased in low-dose and high-dose salidroside groups, especially the increase was significant in the low-dose salidroside group; moreover, the expression of Bax in BMCs was reduced significantly in both low-dose and high-dose salidroside groups.	rhodioloside	162-173	B cell leukemia/lymphoma 2	Mus musculus	32-37	
16334562-4	2005	Additionally, the expression of Bcl-2 in BMCs was increased in low-dose and high-dose salidroside groups, especially the increase was significant in the low-dose salidroside group; moreover, the expression of Bax in BMCs was reduced significantly in both low-dose and high-dose salidroside groups.	rhodioloside	162-173	B cell leukemia/lymphoma 2	Mus musculus	32-37	
16334562-5	2005	CONCLUSION: These data suggest that salidroside may promote the recovery of hematopoietic function of the bone marrow depressed anemia in mice by ending off G0/G1-phase arrest, accelerating G0/G1-S phase and S-G2/M phase transition, up-regulating Bcl-2 expression, down-regulating Bax expression, and inhibiting BMCs apoptosis.	rhodioloside	36-47	B cell leukemia/lymphoma 2	Mus musculus	247-252	
30462331-3	2019	This was greatly alleviated by SAL (25 mg/kg, 50 mg/kg, 100 mg/kg) in a dose-dependent manner (50% effective dose value of 35.7 mg/kg and 61.2 mg/kg, respectively), followed by a distinct increment in anti-apoptotic protein Bcl-2.	rhodioloside	31-34	B cell leukemia/lymphoma 2	Mus musculus	224-229	
27738547-7	2016	Furthermore, Sal could increase the phosphorylation level of Akt and GSK3beta, upregulate the ratio of Bcl-2/Bax, and inhibit the activation of caspase-3, caspase-6, and caspase-9.	rhodioloside	13-16	B cell leukemia/lymphoma 2	Mus musculus	103-108