PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 35591936-1 2022 Objective: Based on the expression changes in the TGF-beta/ALK5/Smad2/3 signal transduction pathway, the repair of cartilage injury in the rabbit knee joint was investigated and evaluated by oral administration of naringin in combination with acellular dermal matrix implantation. naringin 214-222 mothers against decapentaplegic homolog 2 Oryctolagus cuniculus 64-71 35591936-11 2022 Conclusions: Oral administration of naringin, the active ingredient of Rhizoma Drynariae, combined with acellular dermal matrix can achieve better repair effects in both joint structure repair and cartilage quality repair at the defect site when repairing cartilage defects in rabbit knees, and the generation of this effect may be caused by the activation of the TGF-beta/ALK5/Smad2/3 signal transduction pathway by naringin, resulting in the increased expression of TGF-beta2, TGF-beta3, and Sox-9 in cartilage defects. naringin 36-44 mothers against decapentaplegic homolog 2 Oryctolagus cuniculus 378-385