PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	caspase 3	Homo sapiens	80-88	
35119637-8	2022	The effective parameters underlying the anticancer effects of naringenin and naringin include GSK3beta inactivation, suppression of the gene and protein activation of NF-kB and COX-2, JAK2/STAT3 downregulation, downregulation of intracellular adhesion molecules-1, upregulation of Notch1 and tyrocite-specific genes, and activation of p38/MAPK and caspase-3.	naringin	77-85	caspase 3	Homo sapiens	348-357	
34054546-13	2021	In vitro studies revealed that naringin exposure was found to promote apoptosis of RA-FLS, increased the activation of caspase-3, and increased the ratio of Bax/Bcl-2 in a dose-dependent manner.	naringin	31-39	caspase 3	Homo sapiens	119-128	
32343512-6	2020	Naringin increases the protein expression of ER stress sensors, phosphorylates eIF2alpha by and activates apoptosis-associated protein CHOP and other associated proapoptotic proteins (PARP1 and caspase-3).	naringin	0-8	caspase 3	Homo sapiens	194-203	
33192517-3	2020	Treatment with flavonoids (naringenin, quercetin, and naringin) plus Balsamin for 48 h reduced HepG2 and MCF-7 cell viability, increased the activation of caspase-3 and -8, and induced apoptosis through up-regulation of pro-apoptotic genes and down-regulation of anti-apoptotic genes.	naringin	54-62	caspase 3	Homo sapiens	155-171	
31727500-8	2019	In addition, we found that naringin dose-dependently enhanced the expression of Caspase3, cleaved Caspase3 and Bax, and reduced the expression of cyclin D1, c-Myc, survivin, and Bcl-2 in TPC-1 and SW1736 cells.	naringin	27-35	caspase 3	Homo sapiens	98-106	
18803250-2	2008	Three citrus flavonoids - naringin, naringenin and hesperidin - have been examined for their ability to activate caspase-3, a marker of apoptosis execution, in human polymorphonuclear neutrophils in vitro, stimulated and non-stimulated with phorbol 12-myristate 13-acetate.	naringin	26-34	caspase 3	Homo sapiens	113-122	
27496642-6	2016	Furthermore, naringin or glibenclamide significantly reduced caspase-3 and caspase-9 activities in cells that were treated with PIs.	naringin	13-21	caspase 3	Homo sapiens	61-70	
19885011-5	2009	In addition, naringin reduced the enzyme activity of caspase 3 and cleavages of caspase 9, poly (ADP-ribose) polymerase (PARP), and caspase 3.	naringin	13-21	caspase 3	Homo sapiens	53-62	
19885011-5	2009	In addition, naringin reduced the enzyme activity of caspase 3 and cleavages of caspase 9, poly (ADP-ribose) polymerase (PARP), and caspase 3.	naringin	13-21	caspase 3	Homo sapiens	132-141