PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
32346444-0	2020	Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	75-79	
32346444-2	2020	Naringin has an inhibitory effect on the PI3k/AKT/mTOR signaling pathway in various tumor cell types and the effect of naringin is closely related to the occurrence and proliferation of tumor cells.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	50-54	
32346444-10	2020	The results demonstrated that naringin may be a promising therapeutic agent for the treatment of CRC, which may inhibit the proliferation of CRC cells and induce apoptosis by inhibiting the PI3K/AKT/mTOR signaling pathway.	naringin	30-38	mechanistic target of rapamycin kinase	Homo sapiens	199-203	
32346444-3	2020	The aim of this present study was to investigate whether naringin could inhibit the proliferation of CRC cells by inhibiting the PI3K/AKT/mTOR signaling pathway.	naringin	57-65	mechanistic target of rapamycin kinase	Homo sapiens	138-142	
32346444-7	2020	The expression levels of PI3K/AKT/mTOR-related proteins [PI3K, AKT, mTOR, phosphorylated (p)-PI3K, p-AKT and p-mTOR] after naringin stimulation in CRC cells were detected using western blot assays.	naringin	123-131	mechanistic target of rapamycin kinase	Homo sapiens	34-38	
32329644-3	2020	Growth inhibition of AGS cells showed downregulation of PI3K/Akt/mTOR signaling by Naringin treatment.	naringin	83-91	mechanistic target of rapamycin kinase	Homo sapiens	65-69	
32045600-0	2020	Naringin inhibits autophagy mediated by PI3K-Akt-mTOR pathway to ameliorate endothelial cell dysfunction induced by high glucose/high fat stress.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	49-53	
32045600-5	2020	Moreover, Nar increases the phosphorylation levels of phosphatidylinositol-3-kinase (PI3K), protein kinase B (Akt) and mammalian rapamycin target protein (mTOR).	naringin	10-13	mechanistic target of rapamycin kinase	Homo sapiens	155-159	
32329644-5	2020	Rapamycin pre-treatment with Naringin showed significant decrease in mTOR phosphorylation and increase in LC3B activation in AGS cells.	naringin	29-37	mechanistic target of rapamycin kinase	Homo sapiens	69-73	
32346444-9	2020	Naringin promoted the apoptosis of CRC cells and inhibited the activation of the PI3K/AKT/mTOR signaling pathway in a dose-dependent manner.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	90-94	
30197681-6	2018	Suppression of miR-126 expression reduced the anticancer effects of naringin on H69AR cells, reversed the naringin-induced reduction of phosphoinositide 3-kinase/AKT/mTOR, and suppressed VCAM-1 protein levels.	naringin	106-114	mechanistic target of rapamycin kinase	Homo sapiens	166-170	
32329644-6	2020	Decrease in mTOR phosphorylation is associated with lysosomal function activation was observed by time-dependent treatment of Naringin.	naringin	126-134	mechanistic target of rapamycin kinase	Homo sapiens	12-16	
27687505-10	2017	The deactivation of HSCs caused by naringin was not because of the autophagic activation but mTOR inhibition, which was supported by the following evidence: first, naringin induced autophagic activation, but when autophagy was blocked by 3-MA, deactivation of HSCs was not attenuated or reversed.	naringin	35-43	mechanistic target of rapamycin kinase	Homo sapiens	93-97	
27687505-11	2017	Second, naringin inhibited mTOR pathway, meanwhile when mTOR was activated by IGF-1, deactivation of HSCs was reversed.	naringin	8-16	mechanistic target of rapamycin kinase	Homo sapiens	27-31	
27687505-11	2017	Second, naringin inhibited mTOR pathway, meanwhile when mTOR was activated by IGF-1, deactivation of HSCs was reversed.	naringin	8-16	mechanistic target of rapamycin kinase	Homo sapiens	56-60	
26201693-0	2015	Naringin induces autophagy-mediated growth inhibition by downregulating the PI3K/Akt/mTOR cascade via activation of MAPK pathways in AGS cancer cells.	naringin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	85-89