PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31916219-13	2020	These observations indicate that naringin may exert neuroprotective activity against rotenone-induced toxicity in the animals possibly through Nrf2-mediated pathway.	naringin	33-41	NFE2 like bZIP transcription factor 2	Rattus norvegicus	143-147	
33445988-10	2021	Naringin may possess a protective effect through moderating lipopolysaccharide-induced myocardial oxidative stress via the Keap1/Nrf2/HO-1 pathway in rats with SIMD.	naringin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	129-133	
26280522-0	2015	Neuroprotective efficacy of naringin on 3-nitropropionic acid-induced mitochondrial dysfunction through the modulation of Nrf2 signaling pathway in PC12 cells.	naringin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	122-126	
27174133-16	2016	Arsenite-induced alteration in heart Nrf-2, HO-1, Smad-3, and TGF-beta mRNA expression were significantly restored (p < 0.05) by naringin (40 and 80 mg/kg) treatment.	naringin	132-140	NFE2 like bZIP transcription factor 2	Rattus norvegicus	37-42	
27174133-19	2016	CONCLUSION: The results of present investigation suggest that naringin ameliorates arsenite-induced cardiotoxicity via modulation of TGF-beta/Smad-3 and Nrf-2/HO-1 pathways along with a reduction in myocardial apoptosis.	naringin	62-70	NFE2 like bZIP transcription factor 2	Rattus norvegicus	153-158	
31604166-0	2019	Protective effects of naringin and trimetazidine on remote effect of acute renal injury on oxidative stress and myocardial injury through Nrf-2 regulation.	naringin	22-30	NFE2 like bZIP transcription factor 2	Rattus norvegicus	138-143	
31604166-2	2019	The aim of the current study was to examine the effects of naringin (NAR), trimetazidine (TMZ), or their combination on the Nrf-2 expression in the kidney tissue, and myocardial injury in the renal IR injury in rats.	naringin	59-67	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-129	
31604166-2	2019	The aim of the current study was to examine the effects of naringin (NAR), trimetazidine (TMZ), or their combination on the Nrf-2 expression in the kidney tissue, and myocardial injury in the renal IR injury in rats.	naringin	69-72	NFE2 like bZIP transcription factor 2	Rattus norvegicus	124-129	
31604166-8	2019	CONCLUSION: NAR, TMZ, or their combination could attenuate the Nrf-2 expression in the kidney tissue, following the renal IR injury through inhibition of lipid peroxidase, and enhancement of antioxidant activity.	naringin	12-15	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-68	
26280522-10	2015	Further, naringin enhances the nuclear translocation of Nrf2 and induces the NAD(P)H: quinone oxidoreductase-1 and Heme oxygenase-1 expressions through the phosphatidylinositol-3-kinase (PI3K)/Akt signaling pathway.	naringin	9-17	NFE2 like bZIP transcription factor 2	Rattus norvegicus	56-60	
26280522-11	2015	Taken together, the above findings suggest that naringin augments cellular antioxidant defense capacity and reduces the 3-NP-induced neurotoxicity in PC12 cells through the PI-3K/Akt-dependent Nrf2 activation in PC12 cells.	naringin	48-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	193-197	
25773745-0	2015	Naringin protects against anoxia/reoxygenation-induced apoptosis in H9c2 cells via the Nrf2 signaling pathway.	naringin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	87-91	
25773745-12	2015	Therefore, Nar provided cardioprotection by inducing the phosphorylation of ERK1/2, PKCdelta, and AKT, which subsequently activated Nrf2 and its downstream genes.	naringin	11-14	NFE2 like bZIP transcription factor 2	Rattus norvegicus	132-136	
25773745-9	2015	Moreover, the presence of Nar alone in H9c2 cells increased the nuclear translocation of Nrf2 in a dose- and time-dependent manner, as well as consistently increased the protein levels of heme oxygenase (HO-1) and glutamate cysteine ligase (GCLC).	naringin	26-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-93	
22871521-0	2012	Naringin modulates oxidative stress and inflammation in 3-nitropropionic acid-induced neurodegeneration through the activation of nuclear factor-erythroid 2-related factor-2 signalling pathway.	naringin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	130-173	
22871521-9	2012	Naringin induces NAD(P)H:quinone oxidoreductase-1, heme oxygenase-1, glutathione S-transferase P1 and gamma-glutamylcysteine ligase mRNA expressions through the activation of Nrf2 and decreased the expressions of pro-inflammatory mediators like tumour necrosis factor-alpha, cyclooxygenase-2 and inducible nitric oxide synthase.	naringin	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	175-179	
22871521-10	2012	These results indicate that naringin might be beneficial in mitigating 3-NP-induced neurodegeneration through the enhancement of phase II and antioxidant gene expressions via Nrf2 activation; thereby modulating the oxidative stress and inflammatory responses.	naringin	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	175-179