PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34422219-3	2021	The administrations of naringin and hesperidin to diclofenac-injected rats led to a significant decrease in the elevated serum ALT, AST, LDH, ALP, GGT, total bilirubin, TNF-alpha, and IL-17 levels as well as liver lipid peroxidation and liver p53 and caspase-3 mRNA expressions.	naringin	23-31	caspase 3	Rattus norvegicus	251-260	
34536756-5	2021	When compared to the MTX-treated rats, MTX+NG significantly reduced the levels of urea, creatinine, MDA, NO, TNFalpha, IL-6, and caspase-3 activity.	naringin	43-45	caspase 3	Rattus norvegicus	129-138	
33907819-5	2021	The results revealed that naringin pre-treatment significantly attenuated the CoCl2-induced cytotoxicity and apoptosis, and also decreased caspase-3 activity, which had been increased by CoCl2.	naringin	26-34	caspase 3	Rattus norvegicus	139-148	
33445988-7	2021	Naringin also increased superoxide dismutase expression and decreased malondialdehyde, creatine kinase, lactate dehydrogenase, and cleaved caspase-3 expression in rats with SIMD.	naringin	0-8	caspase 3	Rattus norvegicus	139-148	
26337322-11	2015	In conclusion, naringin treatment ameliorates arsenic-induced renal and hepatic damage in rats due its antioxidant and anti-inflammatory properties via down-regulation of elevated oxido-nitrosative stress, KIM-1, Caspase-3, TGF-beta, and TNF-alpha levels.	naringin	15-23	caspase 3	Rattus norvegicus	213-222	
32103758-14	2020	In the naringin-treated groups, the relative mRNA expression levels of caspase-8, caspase-3, and Bax were decreased, whereas that of Bcl-2 was increased.	naringin	7-15	caspase 3	Rattus norvegicus	82-91	
26612654-9	2016	Moreover, naringin inhibited NF-kappaB and iNOS pathways, caspase-3 and p53 activation and improved the histological changes induced by cisplatin.	naringin	10-18	caspase 3	Rattus norvegicus	58-67	
24637089-8	2014	In addition, naringin treatment significantly decreased the amount of cleaved caspase 3, Bax, and p53 protein expression and increased the Bcl-2 protein expression.	naringin	13-21	caspase 3	Rattus norvegicus	78-87	
22453521-10	2012	In addition, naringin treatment significantly increased in Bcl-2:Bax ratio, reduced the enzyme activity of caspase-3 and decreased the number of apoptotic cells after SCI.	naringin	13-21	caspase 3	Rattus norvegicus	107-116	
20691757-4	2010	The results showed that naringin and nobiletin inhibited the decrease of cell viability (MTT reduction), prevented membrane damage (LDH release), scavenged ROS formation, reduced caspase-3 activity, and attenuated the decrease of mitochondrial membrane potential (MMP), respectively, in H(2)O(2)-induced PC12 cells.	naringin	24-32	caspase 3	Rattus norvegicus	179-188