PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33859344-6	2021	Administration of pinocembrin (10 mg/kg, iv) prior t-PA infusion significantly decreased the infarct volume, ameliorated t-PA-induced HT, and protected blood-brain barrier.	pinocembrin	18-29	plasminogen activator, tissue type	Rattus norvegicus	51-55	
33859344-6	2021	Administration of pinocembrin (10 mg/kg, iv) prior t-PA infusion significantly decreased the infarct volume, ameliorated t-PA-induced HT, and protected blood-brain barrier.	pinocembrin	18-29	plasminogen activator, tissue type	Rattus norvegicus	121-125	
29850586-3	2018	In this study, we sought to determine the effect of pinocembrin (PCB; a pleiotropic neuroprotective agent) on t-PA administration-induced BBB damage in a novel rat thromboembolic stroke model.	pinocembrin	52-63	plasminogen activator, tissue type	Rattus norvegicus	110-114	
29850586-3	2018	In this study, we sought to determine the effect of pinocembrin (PCB; a pleiotropic neuroprotective agent) on t-PA administration-induced BBB damage in a novel rat thromboembolic stroke model.	pinocembrin	65-68	plasminogen activator, tissue type	Rattus norvegicus	110-114	
29850586-4	2018	By assessing the leakage of Evans blue into the ischemic hemisphere, we demonstrated that PCB pretreatment 5 min before t-PA administration significantly reduced BBB damage following 2 hr, 4 hr, 6 hr, and even 8 hr ischemia.	pinocembrin	90-93	plasminogen activator, tissue type	Rattus norvegicus	120-124	
29850586-5	2018	Consistently, PCB pretreatment significantly decreased t-PA infusion-resulting brain edema and infarction volume and improved the behavioral outcomes following 6 hr ischemia.	pinocembrin	14-17	plasminogen activator, tissue type	Rattus norvegicus	55-59	
29850586-7	2018	Moreover, PCB pretreatment significantly reduced phosphorylation of platelet-derived growth factor receptor alpha (PDGFRalpha) as compared with t-PA alone.	pinocembrin	10-13	plasminogen activator, tissue type	Rattus norvegicus	144-148	
29850586-9	2018	In conclusion, we demonstrated that PCB pretreatment shortly before t-PA infusion significantly protects BBB function and improves neurological outcomes following prolonged ischemia beyond the regular 4.5 hr t-PA time window.	pinocembrin	36-39	plasminogen activator, tissue type	Rattus norvegicus	208-212	
29850586-10	2018	PCB pretreatment may represent a novel means of increasing the safety and the therapeutic time window of t-PA following ischemic stroke.	pinocembrin	0-3	plasminogen activator, tissue type	Rattus norvegicus	105-109