PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26759700-3	2016	Ginkgolide A, one main component of Ginkgo biloba extracts (GBE), activated PXR and enhanced PXR expression level, displayed both significant therapeutic effect and preventive effect against CCl4-induced mouse hepatitis.	ginkgolide A	0-12	chemokine (C-C motif) ligand 4	Mus musculus	191-195	
31697926-5	2020	This study aims to investigate the effect of GA in activating PXR and improving associated tight junction integrity and reducing bacterial translocation in gut-liver axis of CCl4 induced cirrhosis model.	ginkgolide A	45-47	chemokine (C-C motif) ligand 4	Mus musculus	174-178	
31697926-11	2020	Furthermore, increased (p < 0.01) hepatic and small intestinal NFkappaB was observed in CCl4 induced cirrhotic mice that was significantly (p < 0.05) lowered following GA treatment.	ginkgolide A	174-176	chemokine (C-C motif) ligand 4	Mus musculus	91-95	
31697926-12	2020	Over expression of TLR4/MyD88/NFkappaB axis and its downstream pro-inflammatory mediators TNF-alpha, IL6 and IFN-gamma were observed in CCl4 induced mice, and these indices were abrogated significantly after GA treatment.	ginkgolide A	208-210	chemokine (C-C motif) ligand 4	Mus musculus	136-140	
31697926-13	2020	Furthermore, significantly increased plasma levels of bacterial translocation markers LBP and procalcitonin were found in CCl4 mice, which were reduced significantly (p < 0.05 & p < 0.0001) after GA treatment.	ginkgolide A	206-208	chemokine (C-C motif) ligand 4	Mus musculus	122-126	
31697926-14	2020	CONCLUSION: In conclusion, our data supports the hypothesis that, GA treatment to CCl4 induced cirrhotic mice, activated hepatic and small intestinal PXR and diminished inflammation, thereby improving tight junction integrity and attenuating bacterial translocation.	ginkgolide A	66-68	chemokine (C-C motif) ligand 4	Mus musculus	82-86	
26759700-4	2016	siRNA-mediated decrease of PXR expression significantly reduced the efficacy of Ginkgolide A in treating CCl4-induced inflammation in mice.	ginkgolide A	80-92	chemokine (C-C motif) ligand 4	Mus musculus	105-109	
26759700-7	2016	Inhibition of NF-kappaB activity by NF-kappaB-specific suppressor IkappaBalpha is one of the potential mechanisms of Ginkgolide A against CCl4-induced liver inflammation.	ginkgolide A	117-129	chemokine (C-C motif) ligand 4	Mus musculus	138-142