PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28492556-0	2017	PLSCR1/IP3R1/Ca2+ axis contributes to differentiation of primary AML cells induced by wogonoside.	wogonoside	86-96	phospholipid scramblase 1	Homo sapiens	0-6	
29377576-0	2018	Wogonoside induces depalmitoylation and translocation of PLSCR1 and N-RAS in primary acute myeloid leukaemia cells.	wogonoside	0-10	phospholipid scramblase 1	Homo sapiens	57-63	
29377576-6	2018	Here, we leveraged the observation that nuclear translocation of PLSCR1 could be induced during wogonoside treatment in some primary AML cells, despite their genetic heterogeneity that contributed to the depalmitoylation of PLSCR1 via acyl protein thioesterase 1 (APT-1), an enzyme catalysing protein depalmitoylation.	wogonoside	96-106	phospholipid scramblase 1	Homo sapiens	65-71	
29377576-9	2018	Taken together, our findings provide new insight into the mechanism of wogonoside-induced nuclear translocation of PLSCR1 and illuminate the influence of N-RAS depalmitoylation on its Golgi trafficking and RAF1 signalling inactivation in AML.	wogonoside	71-81	phospholipid scramblase 1	Homo sapiens	115-121	
28492556-3	2017	We have demonstrated that wogonoside possesses differentiation and anti-leukemic effects in AML cell lines by promoting PLSCR1 trafficking into nucleus.	wogonoside	26-36	phospholipid scramblase 1	Homo sapiens	120-126	
28492556-4	2017	Here we report that wogonoside promotes the expression of PLSCR1 and enhances its nuclear translocation and binding to the 1, 4, 5-trisphosphate receptor 1 (IP3R1) promoter in AML patient-derived primary cells.	wogonoside	20-30	phospholipid scramblase 1	Homo sapiens	58-64	
23487022-0	2013	Wogonoside induces cell cycle arrest and differentiation by affecting expression and subcellular localization of PLSCR1 in AML cells.	wogonoside	0-10	phospholipid scramblase 1	Homo sapiens	113-119	
23487022-6	2013	We also demonstrated that wogonoside significantly increased the transcription of phospholipid scramblase 1 (PLSCR1) due to its influence on the expression of cell cycle- and differentiation-related genes, including the upregulation of p21waf1/cip1 and downregulation of the oncogenic protein c-Myc.	wogonoside	26-36	phospholipid scramblase 1	Homo sapiens	82-107	
23487022-6	2013	We also demonstrated that wogonoside significantly increased the transcription of phospholipid scramblase 1 (PLSCR1) due to its influence on the expression of cell cycle- and differentiation-related genes, including the upregulation of p21waf1/cip1 and downregulation of the oncogenic protein c-Myc.	wogonoside	26-36	phospholipid scramblase 1	Homo sapiens	109-115	
23487022-7	2013	Wogonoside also promoted PLSCR1 trafficking into the nucleus and facilitated its binding to the inositol 1,4,5-trisphosphate receptor 1 (IP3R1) promoter, thus increasing the expression of IP3R1.	wogonoside	0-10	phospholipid scramblase 1	Homo sapiens	25-31	
23487022-8	2013	Finally, inhibition of PLSCR1 expression with small interfering RNA partially blocked wogonoside-induced cell cycle arrest and differentiation and disturbed the wogonoside-associated molecular events.	wogonoside	86-96	phospholipid scramblase 1	Homo sapiens	23-29	
23487022-8	2013	Finally, inhibition of PLSCR1 expression with small interfering RNA partially blocked wogonoside-induced cell cycle arrest and differentiation and disturbed the wogonoside-associated molecular events.	wogonoside	161-171	phospholipid scramblase 1	Homo sapiens	23-29