PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32829410-10 2021 In the clinical trials cohort (N=462), CYP2B6 slow metabolizers had lesser weight gain at week 48 among participants receiving efavirenz with tenofovir disoproxil fumarate (p=0.001) but not those receiving efavirenz with abacavir (p=0.65). Tenofovir 142-171 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 39-45 17503755-5 2007 However, under conditions of limited EFV metabolism, that is, the group of 23 individuals carrying two copies of CYP2B6 loss/diminished-function alleles, plasma AUC values were highest among individuals receiving TFV (n=5, 353,031 ng*h/ml), compared with those not receiving TFV (n=18, 180,689 ng*h/ml). Tenofovir 213-216 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 113-119 17503755-5 2007 However, under conditions of limited EFV metabolism, that is, the group of 23 individuals carrying two copies of CYP2B6 loss/diminished-function alleles, plasma AUC values were highest among individuals receiving TFV (n=5, 353,031 ng*h/ml), compared with those not receiving TFV (n=18, 180,689 ng*h/ml). Tenofovir 275-278 cytochrome P450 family 2 subfamily B member 6 Homo sapiens 113-119