PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34863716-0	2022	Irisin rescues diabetic cardiac microvascular injury via ERK1/2/Nrf2/HO-1 mediated inhibition of oxidative stress.	irisin	0-6	mitogen-activated protein kinase 3	Mus musculus	57-63	
34863716-11	2022	Irisin stimulated the phosphorylation of extracellular regulated protein kinases (ERK) 1/2 and nuclear factor erythroid-derived 2-like 2 (Nrf2) nuclear translocation, while U0126 (the inhibitor of ERK1/2) inhibited irisin-induced Nrf2 nuclear translocation and HO-1 expression.	irisin	0-6	mitogen-activated protein kinase 3	Mus musculus	41-90	
34863716-11	2022	Irisin stimulated the phosphorylation of extracellular regulated protein kinases (ERK) 1/2 and nuclear factor erythroid-derived 2-like 2 (Nrf2) nuclear translocation, while U0126 (the inhibitor of ERK1/2) inhibited irisin-induced Nrf2 nuclear translocation and HO-1 expression.	irisin	215-221	mitogen-activated protein kinase 3	Mus musculus	197-203	
34863716-13	2022	CONCLUSION: Irisin could rescue cardiac microvessels against oxidative stress and apoptosis in diabetes via ERK1/2/Nrf2/HO-1 pathway.	irisin	12-18	mitogen-activated protein kinase 3	Mus musculus	108-114