PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31108387-0	2019	Irisin pretreatment ameliorates intestinal ischemia/reperfusion injury in mice through activation of the Nrf2 pathway.	irisin	0-6	nuclear factor, erythroid derived 2, like 2	Mus musculus	105-109	
35370723-0	2022	Post-treatment With Irisin Attenuates Acute Kidney Injury in Sepsis Mice Through Anti-Ferroptosis via the SIRT1/Nrf2 Pathway.	irisin	20-26	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116	
35370723-3	2022	The aim of this study was to verify the occurrence of ferroptosis in the SA-AKI pathogenesis and demonstrate that post-treatment with irisin could restrain ferroptosis and alleviate SA-AKI via activating the SIRT1/Nrf2 signaling pathway.	irisin	134-140	nuclear factor, erythroid derived 2, like 2	Mus musculus	214-218	
35370723-7	2022	Furthermore, our result also revealed that irisin could activate SIRT1/Nrf2 signaling pathways both in vivo and vitro.	irisin	43-49	nuclear factor, erythroid derived 2, like 2	Mus musculus	71-75	
34863716-0	2022	Irisin rescues diabetic cardiac microvascular injury via ERK1/2/Nrf2/HO-1 mediated inhibition of oxidative stress.	irisin	0-6	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68	
34863716-11	2022	Irisin stimulated the phosphorylation of extracellular regulated protein kinases (ERK) 1/2 and nuclear factor erythroid-derived 2-like 2 (Nrf2) nuclear translocation, while U0126 (the inhibitor of ERK1/2) inhibited irisin-induced Nrf2 nuclear translocation and HO-1 expression.	irisin	0-6	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-136	
34863716-11	2022	Irisin stimulated the phosphorylation of extracellular regulated protein kinases (ERK) 1/2 and nuclear factor erythroid-derived 2-like 2 (Nrf2) nuclear translocation, while U0126 (the inhibitor of ERK1/2) inhibited irisin-induced Nrf2 nuclear translocation and HO-1 expression.	irisin	0-6	nuclear factor, erythroid derived 2, like 2	Mus musculus	138-142	
34863716-11	2022	Irisin stimulated the phosphorylation of extracellular regulated protein kinases (ERK) 1/2 and nuclear factor erythroid-derived 2-like 2 (Nrf2) nuclear translocation, while U0126 (the inhibitor of ERK1/2) inhibited irisin-induced Nrf2 nuclear translocation and HO-1 expression.	irisin	215-221	nuclear factor, erythroid derived 2, like 2	Mus musculus	230-234	
34863716-12	2022	Nrf2 siRNA inhibited irisin"s antioxidative effects.	irisin	21-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4	
34863716-13	2022	CONCLUSION: Irisin could rescue cardiac microvessels against oxidative stress and apoptosis in diabetes via ERK1/2/Nrf2/HO-1 pathway.	irisin	12-18	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119	
33440644-2	2021	This study aimed to evaluate the kinetics of antioxidant properties of the adipomyokine irisin administered shortly before or after macrophage activation to assess its effect on the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/HMGB1 pathway.	irisin	88-94	nuclear factor, erythroid derived 2, like 2	Mus musculus	182-225	
33440644-2	2021	This study aimed to evaluate the kinetics of antioxidant properties of the adipomyokine irisin administered shortly before or after macrophage activation to assess its effect on the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1)/HMGB1 pathway.	irisin	88-94	nuclear factor, erythroid derived 2, like 2	Mus musculus	227-231	
33440644-7	2021	In conclusion, irisin is a modulator of the Nrf2/HO-1/HMGB1 pathway and shows antioxidative and anti-inflammatory effects when administered both before and shortly after the activation of inflammatory mechanisms in mouse macrophages.	irisin	15-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	44-48	
31108387-8	2019	Moreover, both in vivo and in vitro results showed that irisin pretreatment significantly upregulated nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protein.	irisin	56-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	102-145	
31108387-8	2019	Moreover, both in vivo and in vitro results showed that irisin pretreatment significantly upregulated nuclear factor (erythroid-derived 2)-like 2 (Nrf2) protein.	irisin	56-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	147-151